GABAA and GABAB agonist microinjections into medial accumbens shell increase feeding and induce anxiolysis in an animal model of anxiety

Lopes, Ana Paula Fraga; Cunha, Isabel Cristina da; Steffens, Sérgio Murilo; Ferraz, Adriana Rodrigues; Vargas, Juliano Cordova; Lima, Thereza Christina Monteiro de; Neto, José Marino; Faria, Moacir Serralvo; Paschoalini, Marta Aparecida

doi:10.1016/j.bbr.2007.07.001

Cited by 34 publications

(18 citation statements)

References 59 publications

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“…As it was previously said, NAS has been early involved in anxiety processes by us and another group [37,44,45], and after it, an important number of laboratories are showing additional evidences on the role of NAS in anxiety, citing our findings [12,15,16,43,65]. All these studies give support to a previous study using immunohistochemical staining for fos-like activity, mapping functional activation of discrete brain areas induced by anxiogenic situations.…”

supporting

confidence: 89%

Differential behavioral profile induced by the injection of dipotassium chlorazepate within brain areas that project to the nucleus accumbens septi

López

Caif

Fraile

et al. 2013

Pharmacological Reports

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Abstract:Background: The effect of the agonism on g-aminobutyric acid (GABA) receptors was studied within medial prefrontal cortex (mPFC), amygdala (AMY) and ventral hipocampus (VH) in the plus-maze test in male rats bilaterally cannulated. These structures send glutamatergic projections to the nucleus accumbens septi (NAS), in which interaction and integration between these afferent pathways has been described. In a previous study of our group, blockade of glutamatergic transmission within NAS induced an anxiolytic like effect. Methods: Three rat groups received either saline or dipotassium chlorazepate (1 or 2 µg/1 µl solution) 15 min before testing. Time spent in the open arms (TSOA), time per entry (TPE), extreme arrivals (EA), open and closed arms entries (OAE, CAE) and relationship between open-and closed-arms quotient (OCAQ) were recorded. Results: In the AMY injected group TSOA, OAE and EA were increased by the higher doses of dipotassium chlorazepate (p < 0.01). In the mPFC, TPE was decreased by both doses (p < 0.05). Injection within ventral hippocampus (VH) decreased TSOA, OAE and OCAQ with lower doses (p < 0.05). When the three studied saline groups were compared, TSOA, OAE, EA and OCAQ were enhanced in the VH group when compared to mPFC and AMY (p < 0.001). Insertion of inner canula (p < 0.001, p < 0.01, p < 0.01) and saline injection showed an increasing significant difference (p < 0.001 in all cases) with the action of guide cannula alone within VH in TSOA, OAE and EA. Conclusion: We conclude that the injection of dipotassium chlorazepate has a differential effect depending of the brain area, leading to facilitatory and inhibitory effects on anxiety processing.

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supporting

confidence: 89%

Differential behavioral profile induced by the injection of dipotassium chlorazepate within brain areas that project to the nucleus accumbens septi

López

Caif

Fraile

et al. 2013

Pharmacological Reports

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“…The stimulation of GABA A /benzodiazepine receptors in the basolateral amygdala by local administration of midazolam and muscimol impaired inhibitory avoidance acquisition, but did not change escape behavior in the elevated T maze (Duzzioni et al, 2008). Benzodiazepine agonist microinjection into the Acb nucleus does not alter open field behavior or other anxiety models, such as the light-dark box and Vogel conflict test, because GABA B receptors may be more important in fear/anxiety regulation than GABA A receptors (Lopes et al, 2007). However, the mechanism of anxiolytic action of G. jasminoides extract and geniposide requires further study.…”

Section: Discussionmentioning

confidence: 91%

Psychopharmacological Profile of the Water Extract of Gardenia jasminoides and Its Constituents, Genipin and Geniposide, in Mice

Choi¹,

Peña²,

Choi³

et al. 2008

Biomolecules and Therapeutics

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− Gardenia jasminoides (G. jasminoides) is traditionally used to treat insomnia, jaundice, emotional disorders, hepatic disease, and inflammatory disease. Previously, we found that geniposide and the water extract of G. jasminoides increased Cl -influx in neuroblastoma. Here we examined the psychopharmacological activities of G. jasminoides and its constituents. G. jasminoides extract was orally administered at 100 and 200 mg/kg, and genipin and geniposide were intraperitoneally injected at 2, 10, and 20 mg/kg. Electroshock stress decreased open arm activity, but the extract and geniposide (20 mg/kg) significantly reversed that effect. This results indicate that G. jasminoides extract and geniposide alleviated anxiety with greater efficacy in stressed animals than normal animals.

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“…The involvement of GABA receptors in modulatory of anxiety has been the subject of extensive studies. (Lopes, Ganzer et al;Lopes, da Cunha et al, 2007). Furthermore, GABA-ergic neurons throughout the CNS express high levels of CB1 receptor immunoreactivity, advancing the notion that cannabinoid and GABA receptors interact to mediate a number of pharmacological endpoints (Marsicano and Lutz 1999).…”

Section: Introductionmentioning

confidence: 99%

“…GABA (A) and GABA (B) agonists microinjection into the NAc shell in both free-feeding animals (Lopes, da Cunha et al, 2007) and food-deprived rats (Lopes, Ganzer et al) induced anxiolysis in an animal model of anxiety. In addition, injection of Muscimol into the NAc shell evoked a strong defensive burying or paw-treading behavior (Reynolds and Berridge 2001).…”

Section: The Effects Of Gaba (A) System In the Nac Shell On Anxiety-lmentioning

confidence: 99%

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Interaction of GABA (A) system in the nucleus accumbens ahell with ACPA on anxiety-like behaviors in Wistar male rat

Zarrindast¹,

Ahmadi²,

Nasehi³

2013

J. Exper. Appl. Anim. Sci.

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It has been recently reported that cannabinoid and GABA systems in the nucleus accumbens (NAc) are involved in anxiety-related behaviors. Thus the purpose of the present study is to investigate the involvement of ACPA interaction with GABA-ergic of the NAc shell in anxiolytic-like behaviors in Wistar male rat. The elevated plus maze apparatus has been used to test parameters of anxiety-like behaviors. The data demonstrated that bilateral injection of GABA (A) receptor agonist (Muscimol 0.4 μg/μl) increased % OAT. Furthermore, injection of GABA (A) receptor antagonist (Bicuculline 0.9μg/μl) increased locomotor activity. The data indicated anxiolytic-like behaviors caused by the Muscimol injection into the NAc shell. Moreover, bilateral injection of ACPA (CB1 -selective agonists; 0.025μg/μl) into the NAc shell induced anxiogenic-like behaviors. The final results showed that intra-NAc shell injection of subthreshold dose of Muscimol (0.2 μg/μl) attenuated anxiogenic-like behaviors by higher dose (0.025 μg/μl) of ACPA in the NAc shell. In addition, intra-NAc shell injection of subthreshold dose of Bicuculline (0.6 μg/μl) did not alter anxiogenic response by ACPA administration in the NAc shell. The results suggested that the activation of the NAc shell GABA (A) receptor attenuated the activity of cannabinoid system in the NAc shell.

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GABAA and GABAB agonist microinjections into medial accumbens shell increase feeding and induce anxiolysis in an animal model of anxiety

Cited by 34 publications

References 59 publications

Differential behavioral profile induced by the injection of dipotassium chlorazepate within brain areas that project to the nucleus accumbens septi

Differential behavioral profile induced by the injection of dipotassium chlorazepate within brain areas that project to the nucleus accumbens septi

Psychopharmacological Profile of the Water Extract of Gardenia jasminoides and Its Constituents, Genipin and Geniposide, in Mice

Interaction of GABA (A) system in the nucleus accumbens ahell with ACPA on anxiety-like behaviors in Wistar male rat

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