GABA-mediated changes in inter-hemispheric beta frequency activity in early-stage Parkinson’s disease

Hall, Stephen D.; Prokic, Emma J.; McAllister, Craig; Rönnqvist, Kim C.; Williams, Adrian; Yamawaki, Naoki; Witton, Caroline; Woodhall, Gavin L.; Stanford, Ian M.

doi:10.1016/j.neuroscience.2014.09.037

Cited by 52 publications

(59 citation statements)

References 40 publications

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“…Red and blue represent higher respectively lower values found in PD patients compared with controls; Black lines represent no significant difference between PD patients and controls, or no comparison with a control group. References: (Hall et al, ; Heinrichs‐Graham, Kurz, et al, ; Hirschmann et al, ; Hirschmann, Ozkurt, et al, ; Litvak et al, ; Litvak et al, ; Oswal, Beudel, et al, ; Pollok et al, ; Pollok et al, ; Salenius et al, ; van Wijk et al, ; Vardy et al, ). (b)Overview of main findings in tremor network‐focused research.…”

Section: Resultsmentioning

confidence: 99%

“…Hall and coworkers found larger resting‐state beta band power in the motor cortex contralateral to the most affected hemibody in DRT‐naïve patients. The benzodiazepine zolpidem, known for its modulating effects on PD motor symptoms, normalized the ratio in resting‐state beta band power between the “affected” and “nonaffected” motor cortex and this correlated positively with improvement in UPDRS‐III scores (Hall et al, ). Cortico‐muscular coherence (CMC) has been studied by correlating M1 activity with EMG signals recorded in the forearm.…”

Section: Resultsmentioning

confidence: 99%

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A systematic review of MEG‐based studies in Parkinson's disease: The motor system and beyond

Boon

Geraedts

Hillebrand

et al. 2019

Human Brain Mapping

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Parkinson's disease (PD) is accompanied by functional changes throughout the brain, including changes in the electromagnetic activity recorded with magnetoencephalography (MEG). An integrated overview of these changes, its relationship with clinical symptoms, and the influence of treatment is currently missing. Therefore, we systematically reviewed the MEG studies that have examined oscillatory activity and functional connectivity in the PD‐affected brain. The available articles could be separated into motor network‐focused and whole‐brain focused studies. Motor network studies revealed PD‐related changes in beta band (13–30 Hz) neurophysiological activity within and between several of its components, although it remains elusive to what extent these changes underlie clinical motor symptoms. In whole‐brain studies PD‐related oscillatory slowing and decrease in functional connectivity correlated with cognitive decline and less strongly with other markers of disease progression. Both approaches offer a different perspective on PD‐specific disease mechanisms and could therefore complement each other. Combining the merits of both approaches will improve the setup and interpretation of future studies, which is essential for a better understanding of the disease process itself and the pathophysiological mechanisms underlying specific PD symptoms, as well as for the potential to use MEG in clinical care.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

A systematic review of MEG‐based studies in Parkinson's disease: The motor system and beyond

Boon

Geraedts

Hillebrand

et al. 2019

Human Brain Mapping

View full text Add to dashboard Cite

show abstract

“…3A). GABA, as an inhibitory neurotransmitter, also functions in multiple physiological processes and is directly associated with anxiety and depression (Kalueff and Nutt, 2007; Hall et al , 2014). Similar to 5-HT, the concentration of GABA in the host is also affected by gut microbiota (Barrett et al , 2012; Sampson and Mazmanian, 2015).…”

Section: Discussionmentioning

confidence: 99%

Manganese-induced sex-specific gut microbiome perturbations in C57BL/6 mice

Chi

Gao

Bian

et al. 2017

Toxicology and Applied Pharmacology

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Overexposure to manganese (Mn) leads to toxic effects, such as promoting the development of Parkinson’s-like neurological disorders. The gut microbiome is deeply involved in immune development, host metabolism, and xenobiotics biotransformation, and significantly influences central nervous system (CNS) via the gut-brain axis, i.e. the biochemical signaling between the gastrointestinal tract and the CNS. However, it remains unclear whether Mn can affect the gut microbiome and its metabolic functions, particularly those linked to neurotoxicity. In addition, sex-specific effects of Mn have been reported, with no mechanism being identified yet. Recently, we have shown that the gut microbiome is largely different between males and females, raising the possibility that differential gut microbiome responses may contribute to sex-selective toxicity of Mn. Here, we applied high-throughput sequencing and gas chromatography–mass spectrometry (GC-MS) metabolomics to explore how Mn2+ exposure affects the gut microbiome and its metabolism in C57BL/6 mice. Mn2+ exposure perturbed the gut bacterial compositions, functional genes and fecal metabolomes in a highly sex-specific manner. In particular, bacterial genes and/or key metabolites of neurotransmitter synthesis and pro-inflammatory mediators are significantly altered by Mn2+ exposure, which can potentially affect chemical signaling of gut-brain interactions. Likewise, functional genes involved in iron homeostasis, flagellar motility, quorum sensing, and Mn transportation/oxidation are also widely changed by Mn2+ exposure. Taken together, this study has demonstrated that Mn2+ exposure perturbs the gut microbiome and its metabolic functions, which highlights the potential role of the gut microbiome in Mn2+ toxicity, particularly its sex-specific toxic effects.

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“…Such a post-movement β-rebound is a known phenomenon: It is reported to be stronger (i) when a motor program lasted longer (Erbil and Ungan 2007), (ii) when it was finished in a natural time-course in contrast to forced termination (Alegre et al 2008) and (iii) when active instead of passive movement was performed (Keinrath et al 2006). The β-rebound has moreover been suggested to be GABA mediated (Hall et al 2014) and to reflect post-training plastic changes (Mary et al 2015). We might therefore speculate that the features (more involved subjects, long-lasting and natural motor imagery, plastic changes) also apply to those trials in this study with a positive learning incentive.…”

Section: Multi-dimensional Feedback and Processing Capacitymentioning

confidence: 99%

What is the optimal task difficulty for reinforcement learning of brain self-regulation?

Bauer

Vukelić

Gharabaghi

2016

Clinical Neurophysiology

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GABA-mediated changes in inter-hemispheric beta frequency activity in early-stage Parkinson’s disease

Cited by 52 publications

References 40 publications

A systematic review of MEG‐based studies in Parkinson's disease: The motor system and beyond

A systematic review of MEG‐based studies in Parkinson's disease: The motor system and beyond

Manganese-induced sex-specific gut microbiome perturbations in C57BL/6 mice

What is the optimal task difficulty for reinforcement learning of brain self-regulation?

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