Ga and Ce ion-doped phosphate glass fibres with antibacterial properties and their composite for wound healing applications

Wound dressings produced by electrospinning exhibit a fibrous structure close to the one of the extracellular matrix of the skin. In this article, electrospinning was used to fabricate fiber mats based on the well-known biopolymers poly(ϵ-caprolactone) (PCL) and methylcellulose (MC) using benign solvents. The blend fiber mats were crosslinked using Manuka honey and additionally used as a biodegradable platform to deliver bioactive glass particles. It was hypothesized that a dual therapeutic effect can be achieved by combining Manuka honey and bioactive glass. Morphological and chemical examinations confirmed the successful production of submicrometric PCL-MC fiber mats containing Manuka honey and bioactive glass particles. The multifunctional fiber mats exhibited improved wettability and suitable mechanical properties (ultimate tensile strength of 3-5 MPa). By performing dissolution tests using simulated body fluid, the improved bioactivity of the fiber mats by the addition of bioactive glass was confirmed. Additionally, cell biology tests using human dermal fibroblasts and human keratinocytes-like HaCaT cells showed the potential of the fabricated composite fiber mats to be used as wound dressing, specially due to the ability to support wound closure influenced by the presence of bioactive glass. Moreover, based on the results of the antibacterial tests, it is apparent that an optimization of the electrospun fiber mats is required to develop suitable wound dressing for the treatment of infected wounds.

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“…leading to the "closure of the wound." 71,79 According to Figure 7, in contrast to the negative reference and similar to the positive control,…”

Section: In Vitro Bioactivity Of Electrospun Composite Fibersmentioning

confidence: 96%

Production of a novel poly(ɛ‐caprolactone)‐methylcellulose electrospun wound dressing by incorporating bioactive glass and Manuka honey

et al. 2020

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“…In addition, studies have shown that diabetic wound is often the most suitable place for microbial colonization, because of its hyperglycemia, which can easily give rise to wound infection [ 27 ]. CeO 2 can separate the outer membrane from the cytoplasmic membrane to inhibit the growth of bacteria [ 33 ]. Zheng et al have prepared Ag modified mesoporous bioactive glass nanoparticles and proved that it can inhibit bacteria [ 34 ].…”

Section: Discussionmentioning

confidence: 99%

Multifunctional Injectable Hydrogel Loaded with Cerium-Containing Bioactive Glass Nanoparticles for Diabetic Wound Healing

et al. 2021

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Diabetic foot wound healing is a major clinical problem due to impaired angiogenesis and bacterial infection. Therefore, an effective regenerative dressing is desiderated with the function of promoting revascularization and anti-bacteria. Herein, a multifunctional injectable composite hydrogel was prepared by incorporation of the cerium-containing bioactive glass (Ce-BG) into Gelatin methacryloyl (GelMA) hydrogel. The Ce-BG was synthesized by combining sol-gel method with template method, which maintained spherical shape, chemical structure and phase constitution of bioactive glass (BG). The Ce-BG/GelMA hydrogels had good cytocompatibility, promoted endothelial cells migration and tube formation by releasing Si ion. In vitro antibacterial tests showed that 5 mol % CeO2-containing bioactive glass/GelMA (5/G) composite hydrogel exhibited excellent antibacterial properties. In vivo study demonstrated that the 5/G hydrogel could significantly improve wound healing in diabetic rats by accelerating the formation of granulation tissue, collagen deposition and angiogenesis. All in all, these results indicate that the 5/G hydrogel could enhance diabetic wound healing. Therefore, the development of multifunctional materials with antibacterial and angiogenic functions is of great significance to promote the repair of diabetic wound healing.

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“…Bioactive glasses were previously proven as suitable additives for promoting different stages of skin wounds [ 42 , 43 ]. Up to now, various formulations of bioactive glasses, including silicate-, phosphate-, as well as borate- and borosilicate-based glasses, have been investigated in treating skin injuries with promising outcomes [ 44 , 45 , 46 ]. It should be pointed out that researchers often deliberately incorporated a range of metallic elements (e.g., Cu and Co) into the glass structure as dopants to provide glasses with specific biological features (e.g., improved angiogenesis) that are useful for obtaining an accelerated wound healing [ 47 , 48 ].…”

Section: Current Therapies In Managing Wounds and The Potential Of Mesoporous Materialsmentioning

confidence: 99%

Mesoporous Silica Nanoparticles and Mesoporous Bioactive Glasses for Wound Management: From Skin Regeneration to Cancer Therapy

et al. 2021

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Exploring new therapies for managing skin wounds is under progress and, in this regard, mesoporous silica nanoparticles (MSNs) and mesoporous bioactive glasses (MBGs) offer great opportunities in treating acute, chronic, and malignant wounds. In general, therapeutic effectiveness of both MSNs and MBGs in different formulations (fine powder, fibers, composites etc.) has been proved over all the four stages of normal wound healing including hemostasis, inflammation, proliferation, and remodeling. The main merits of these porous substances can be summarized as their excellent biocompatibility and the ability of loading and delivering a wide range of both hydrophobic and hydrophilic bioactive molecules and chemicals. In addition, doping with inorganic elements (e.g., Cu, Ga, and Ta) into MSNs and MBGs structure is a feasible and practical approach to prepare customized materials for improved skin regeneration. Nowadays, MSNs and MBGs could be utilized in the concept of targeted therapy of skin malignancies (e.g., melanoma) by grafting of specific ligands. Since potential effects of various parameters including the chemical composition, particle size/morphology, textural properties, and surface chemistry should be comprehensively determined via cellular in vitro and in vivo assays, it seems still too early to draw a conclusion on ultimate efficacy of MSNs and MBGs in skin regeneration. In this regard, there are some concerns over the final fate of MSNs and MBGs in the wound site plus optimal dosages for achieving the best outcomes that deserve careful investigation in the future.

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Ga and Ce ion-doped phosphate glass fibres with antibacterial properties and their composite for wound healing applications

Abstract: Soluble Ga/Ce-doped phosphate glass fibres exhibiting controlled release of ions were developed and characterised for wound healing applications. Fibres did not disturb the proliferation and migration of cells and showed antibacterial properties.

Cited by 36 publications

References 62 publications

Production of a novel poly(ɛ‐caprolactone)‐methylcellulose electrospun wound dressing by incorporating bioactive glass and Manuka honey

Production of a novel poly(ɛ‐caprolactone)‐methylcellulose electrospun wound dressing by incorporating bioactive glass and Manuka honey

Multifunctional Injectable Hydrogel Loaded with Cerium-Containing Bioactive Glass Nanoparticles for Diabetic Wound Healing

Mesoporous Silica Nanoparticles and Mesoporous Bioactive Glasses for Wound Management: From Skin Regeneration to Cancer Therapy

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