G2P[4] the most prevalent rotavirus genotype in 2007 winter season in an European non-vaccinated population

Antunes, Henedina; Afonso, Ariana; Iturriza‐Gómara, Miren; Martinho, Isabel; Ribeiro, Cristiana; Rocha, Sandra Cristina dos Santos; Magalhães, Catarina; Carvalho, Liliana; Branca, Fernando; Gray, Jim

doi:10.1016/j.jcv.2009.03.010

Cited by 37 publications

(20 citation statements)

References 19 publications

(57 reference statements)

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“…Also, the first reports of G1/G8 mixed infection have been documented in young children with gastroenteritis in Ireland and Nigeria [29,30]. We found mixed infections with two different rotavirus genotypes in 2.66 % of children, which is similar to previous studies, with a range of 1-26.4 % [31]. These mixed infections occur more frequently in areas with high incidence of rotavirus infection.…”

Section: Rotavirus Genotypingsupporting

confidence: 89%

Prevalence and Molecular Genotyping of Group A Rotaviruses in Iranian Children

Kargar

Akbarizadeh

2012

Indian J. Virol.

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Rotavirus is the leading cause of acute gastroenteritis in worldwide young children. Effective vaccines to prevent rotavirus infection are currently available, although their clinical use is still limited, and rotavirus still causes many episodes of infantile gastroenteritis, mainly during the winter season. The aim of this study was to evaluate the prevalence of rotavirus infection in children aged \5-years-old who were hospitalised for gastroenteritis. One hundred and sixty-three stool samples from hospitalised children (\5-years-old) complicated with severe diarrhoea, in two hospitals in Jahrom City, Iran were collected from 2009 to 2010. Antigenic prevalence of rotavirus group A was distinguished by enzyme immunoassay. The antigen of group A rotavirus was diagnosed by EIA in 75 of 163 collected samples. The genotype of EIA-positive samples was determined by nested RT-PCR. The frequency of rotavirus genotypes G1, G2, G3, G4 and G9 was 17.33, 13.34, 2.67, 30.66 and 2.67 %, respectively. Also, the frequency of mixed and non-typable genotypes was detected in 2.67 and 30.66 %, respectively. G1/G8 mixed infection was the first of these rotavirus genotypes to be reported in Iran. Detection of high prevalence of group A rotavirus infection in hospitalised children with diarrhoea, and determination of circulating rotavirus genotypes in this region of Iran, provide useful data for formulating effective vaccines; especially for infants less than 5-years-old.

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Section: Rotavirus Genotypingsupporting

confidence: 89%

Prevalence and Molecular Genotyping of Group A Rotaviruses in Iranian Children

Kargar

Akbarizadeh

2012

Indian J. Virol.

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“…Alternativamente à proposição de que a vacina RIX4414 criava condições em que o G2P [4] poderia ter adquirido vantagem seletiva, uma periodicidade temporal, dentro de padrão cíclico de ~ 10 anos do G2P [4] foi observada no Brasil 11 e deve ser considerada uma explicação alternativa ao aumento na taxa de detecção desse genótipo desde 2006. Embora tal periodicidade possa estar relacionada à introdução da vacina contra RVA 11 , o genótipo G2P [4] também foi o tipo mais prevalente de RVA detectado em 2007 no noroeste de Portugal, uma população que não havia recebido vacina contra RVA 12 . Portanto, ao menos em alguns contextos, essa prevalência não pode ser explicada pela introdução da vacinação e pode refletir flutuação normal de genótipos do RVA co-circulantes, o que está de acordo com relatos de outros países e áreas, em população não vacinada, mostrando exatamente os mesmos resultados 13 , inclusive na América do Sul 14 .…”

Section: Discussionunclassified

Characterization of rotavirus strains from day care centers: pre- and post-rotavirus vaccine era

Morillo¹,

Luchs²,

Cilli³

et al. 2010

J Pediatr (Rio J)

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Objectives: In 2006 the rotavirus vaccine was included in the Brazilian Immunization Program. The aim of this study was to report the results of a 5-year surveillance study of rotavirus strains in children < 5 years with acute gastroenteritis from day care centers in the state of São Paulo, Brazil. Methods Conclusões:A distribuição do genótipo variou de acordo com os anos, acompanhada pela redução no número de casos detectados. É necessário intensificar a vigilância pós-implantação da vacina contra rotavírus, visando monitorar as linhagens circulantes e sua eficácia contra possíveis genótipos emergentes. J Pediatr (Rio J). 2010;86(2):155-158:Rotavírus, creches, gastroenterites. Characterization of rotavirus strains from day care centers:pre-and post-rotavirus vaccine era IntroduçãoPatógenos virais são as causas mais comuns de gastroenterite em comunidades e em outros contextos, inclusive em instituições semifechadas e hospitais 1 . Na infância, os rotavírus do grupo A (RVA) são considerados o agente etiológico mais importante de gastroenterite não-bacteriana aguda, inclusive surtos e casos esporádicos, independentemente das melhorias em saneamento básico e procedimentos higiênicos 2 . Os RVA são o principal agente etiológico em diarreia aguda

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“…During 2004-2005, G1 and G9 both predominated in different countries [33]. In contrast, later reports suggest an increase in the prevalence of G2P [4] strains circulating among nonvaccinated European children during the 2007-2008 RV season [2]. Such geographic and temporal variation in RVtype distribution is not unexpected [8,12,13,18,19,31].…”

Section: Incidence Of Rvgementioning

confidence: 99%

Primary care-based surveillance to estimate the burden of rotavirus gastroenteritis among children aged less than 5 years in six European countries

Díez-Domingo

Baldó

Patrzałek³

et al. 2010

Eur J Pediatr

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This observational, prospective study was undertaken to estimate the burden of rotavirus (RV) gastroenteritis (GE) leading to general practitioner (GP)/family paediatrician (FP) visits among children aged <5 years in Czech Republic, Germany, Italy, Poland, Spain and the UK. Children aged <5 years presenting with acute GE provided stool samples for rapid RV testing. RV+ samples were confirmed and typed by RT-PCR. Demographic and clinical data were collected for all RVGE episodes. Transmission patterns among other household children aged <5 years were also assessed. From November 2005 to May 2007, excluding data from the UK, 497/3,813 (13.0%) children aged <5 years presenting with acute GE to GP/FP and tested were RV+ by PCR. Most RVGE cases (69.1%) occurred in children aged <2 years, occurred between December and May (93.1%) and were moderate or severe by Vesikari score (92.9%). RV strain distribution varied between countries: G9P[8] was the most common type in Poland (54/76) and Spain (172/196), G1P[8] was predominant in the Czech Republic (56/64) and Italy (46/107), and G4P[8] and G1P[8] both prevailed in Germany (17/54 and 13/54, respectively). A total of 24/122 (19.7%) children aged <5 years resident in the same household as a PCR+ study participant also developed RVGE. Conclusion. This multinational epidemiological study in Europe shows that RV is easily transmitted among household children, with RVGE burden highest among children aged <2 years accessing primary healthcare for acute GE.

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G2P[4] the most prevalent rotavirus genotype in 2007 winter season in an European non-vaccinated population

Cited by 37 publications

References 19 publications

Prevalence and Molecular Genotyping of Group A Rotaviruses in Iranian Children

Prevalence and Molecular Genotyping of Group A Rotaviruses in Iranian Children

Characterization of rotavirus strains from day care centers: pre- and post-rotavirus vaccine era

Primary care-based surveillance to estimate the burden of rotavirus gastroenteritis among children aged less than 5 years in six European countries

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