G2 rotavirus within an emergent VP7 evolutionary lineage circulating in children with acute diarrhea in Guangxi Province of China, 2014

Abstract

Routine surveillance revealed that the prevalence of P[4] rotaviruses circulating in children with acute diarrhea in Guangxi Province, China, increased in 2014. However, VP7 genotyping for these P[4] rotaviruses was unsuccessful. Exhaustive database searching and sequence analysis indicated that the G genotype of these P[4] rotaviruses was G2, and the VP7 genes clustered with recently emerging G2 strains in several countries within an emergent evolutionary lineage that was distinct from the previously designated lineages I-IV as well as lineage V including porcine rotaviruses. Further studies are essential to monitor the potential global spread of this emerging G2 rotavirus.

Circulating rotavirus strains in children with acute gastroenteritis in Iran, 1986 to 2023 and their genetic/antigenic divergence compared to approved vaccines strains (Rotarix, RotaTeq, ROTAVAC, ROTASIIL) before mass vaccination: Clues for vaccination policy makers

“…According to the phylogenetic analysis of the VP7 sequence of various rotavirus genotypes, including G1-G4, G9, and G12, from the global rotavirus database, these genotypes are clustered into several separate evolutionary lineages. In this context, G1 ( Phan et al, 2007a ), G2 ( Dong et al, 2016 ; Trinh et al, 2010 ), G3 ( Degiuseppe et al, 2014 ; Gómez et al, 2014 ), G4 ( Ianiro et al, 2015 ), G9 ( Phan et al, 2007c ) and G12 ( Wangchuk et al, 2014 ) have lineages of I-XI, I-VI, I-IV, I-VII, I-VI and I-IV, respectively. The VP7 trimer consists of two antigenic epitopes, 7–1 and 7–2, with 7–1 further divided into 7–1a and 7–1b ( Aoki et al, 2009 ).…”