2016
DOI: 10.1016/j.bbrc.2016.04.106
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FXR blocks the growth of liver cancer cells through inhibiting mTOR-s6K pathway

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Cited by 20 publications
(18 citation statements)
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“…In our study, ileal FXR expression is significantly lower after RYGB. Since FXR inhibits mTOR-S6K signaling pathway in liver cancer cells [ 46 ], reduction of ileal FXR may contribute to the hyperactivation of mTORC1 signaling after RYGB operation.…”
Section: Discussionmentioning
confidence: 99%
“…In our study, ileal FXR expression is significantly lower after RYGB. Since FXR inhibits mTOR-S6K signaling pathway in liver cancer cells [ 46 ], reduction of ileal FXR may contribute to the hyperactivation of mTORC1 signaling after RYGB operation.…”
Section: Discussionmentioning
confidence: 99%
“…However, there were various reports that FXR was elevated in multiple human cancers responsible for their initiation and progression [28, 29]. For instance, it is stated that FXR could suppress the proliferation of liver cancer via the inhibition of mTOR/S6K signaling [8]. On the other hand, some of the reports proposed the opposite; they showed that that the inhibition of FXR limits esophageal cancer growth [10].…”
Section: Discussionmentioning
confidence: 99%
“…Farnesoid X receptor (FXR) was a key receptor of BAs, and it was overexpression in various human malignancies associating with anti- and/or pro-tumoral roles. For instance, prior studies indicated that inactivation of FXR in cancer of liver and breast corresponded with increased propagation and decreased apoptosis [8, 9]. While, a study by B Guan and colleagues showed the opposite, they found that FXR inhibition limits the growth of esophageal cancer [10].…”
Section: Introductionmentioning
confidence: 99%
“…It has been well documented that FXR also suppresses liver carcinogenesis and progression (5)(6)(7)(8). FXR may serve an indispensable role in inhibiting the activity of signaling pathways that are dysregulated in liver cancer cells (9).…”
Section: Introductionmentioning
confidence: 99%
“…It has been previously reported that FXR downregulation was correlated with the presence of multiple malignant clinicopathological features, including tumor size, advanced BCLC stage, poor differentiation and absence of encapsulation, in patients with HCC (7). FXR inhibited liver cancer cell proliferation in vivo and in vitro via inactivation of the mammalian target of rapamycin (mTOR)/ribosomal S6 kinase (S6K) pathway (9). The current study aimed to investigate whether FXR influenced the regulation liver cancer metastasis and the possible underlying mechanism.…”
Section: Introductionmentioning
confidence: 99%