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Abstract

Futuros possíveis

Anatomo‐comparative study of formaldehyde, alcohol, and saturated salt solution as fixatives in Wistar rat brains

“…Formaldehyde fixation seems to have increased brain, whereas alcohol proportionally decreased it, thus corroborating the literature data (Oliveira et al, 2013;Rodrigues, 2010). Despite saturated salt solution maintaining brain weight, it apparently decreases its dimensions accordingly comparing with formaldehyde modifications.…”

“…In turn, obtaining new anatomic parts has been rare (Balta et al, 2015) -as cultural changes and body donation programs have been slowly introduced, also jeopardizing health academic education, since studies have to be performed in very worn-out pieces. In addition, formaldehyde has been the most used fixative and conservation solution over time by anatomists due to its good performance, despite generating some changes in the original characteristics of the specimens, such as colouring (Oliveira et al, 2013). Due to its toxicity, new conservation methods have been sought (Cisne et al, 2018;Hammer et al, 2012;Piatek-Koziej et al, 2019), such as glycerin, honey, and tannic acid solution.…”

“…Formaldehyde was discovered in 1867 by August Wilhelm von Hoffman (Jabir et al, 2018), but only in 1893 was it included as a fixative and became an essential product for the maintenance of anatomical parts (Balta et al, 2015). Formaldehyde solution with concentrations ranging from 3% to 10% is more widely used due to its wide availability, simplicity of technique, cost, and time of action, which is relatively shorter than any other fixative available on the market (Oliveira et al, 2013). However, it promotes darkening and weight increase of the piece, besides emitting vapours that cause mucosal and eye irritability (Oliveira et al, 2013).…”

“…Formaldehyde solution with concentrations ranging from 3% to 10% is more widely used due to its wide availability, simplicity of technique, cost, and time of action, which is relatively shorter than any other fixative available on the market (Oliveira et al, 2013). However, it promotes darkening and weight increase of the piece, besides emitting vapours that cause mucosal and eye irritability (Oliveira et al, 2013). Prolonged inhalation can cause epistaxis and dizziness, thus being considered carcinogenic.…”