Future prospects of systemic host modulatory agents in periodontal therapy

Gokhale, Sneha; Padhye, Ashvini

doi:10.1038/sj.bdj.2013.432

Cited by 23 publications

(17 citation statements)

References 33 publications

(35 reference statements)

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“…Current therapies for periodontal disease involve mechanical and surgical procedures that do not allow for the recovery of lost tissue. Drugs used and tested to treat osteoporosis, such as bisphosphonates , statins , β‐blockers and anti‐receptor activator of nuclear factor kappa‐B ligand and sclerostin antibodies , as well as anabolic agents such as parathyroid hormone have been studied in periodontal disease with good results. Previous studies showed that LP533401 was effective in preventing systemic bone loss, and enhanced bone mass in mice and rats .…”

Section: Discussionmentioning

confidence: 99%

The effect of an inhibitor of gut serotonin (LP533401) during the induction of periodontal disease

Lima

Corazza

Moraes

et al. 2016

J of Periodontal Research

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Background and Objective LP533401 is an inhibitor of tryptophan hydroxylase 1, which regulates serotonin production in the gut. Previous work indicates that LP533401 has an anabolic effect in bone. Thus, we hypothesized that inhibition of gut serotonin production may modulate the host response in periodontal disease. In this study, we aimed to analyze the effects of LP533401 in a rat periodontitis model to evaluate the role of gut serotonin in periodontitis pathophysiology. Material and Methods Twenty-four rats were divided into three groups: treated group (T: ligature-induced periodontal disease and LP533401, 25 mg/kg/d) by gavage; ligature group (L: ligature-induced periodontal disease only); and control group (C: without ligature-induced periodontal disease). After 28 d, radiographic alveolar bone support was measured on digital radiographs, and alveolar bone volume fraction, tissue mineral density and trabeculae characteristics were quantified by microcomputed tomography in the right hemi-mandible. Left hemi-mandibles were decalcified and alveolar bone loss, attachment loss and area of collagen in the gingiva were histologically analyzed. Results Significant difference between the L and C groups was found, confirming that periodontal disease was induced. We observed no difference between the T and L groups regarding alveolar bone destruction and area of collagen. Conclusion LP533401 (25 mg/kg/d) for 28 d does not prevent bone loss and does not modulate host response in a rat model of induced periodontal disease.

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Section: Discussionmentioning

confidence: 99%

The effect of an inhibitor of gut serotonin (LP533401) during the induction of periodontal disease

Lima

Corazza

Moraes

et al. 2016

J of Periodontal Research

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“…Osteoclast activation is central in the pathogenesis of periodontitis 37–39 . Pharmacologic inhibitors of osteoclast function or differentiation attenuate bone loss in animal models of periodontitis and have been entertained as potential interventions for periodontal disease 40–45 . Systemic hormones and inflammatory cytokines play key role in osteoclast formation and activation 38, 43, 46, 47 .…”

Section: Discussionmentioning

confidence: 99%

“…*P <0.05; † P <0.01. disease. [40][41][42][43][44][45] Systemic hormones and inflammatory cytokines play key roles in osteoclast formation and activation. 38,43,46,47 Indeed, association of systemic diseases that show increased osteoclast activity with periodontal bone loss has been explored.…”

Section: Discussionmentioning

confidence: 99%

Diverse Osteoclastogenesis of Bone Marrow From Mandible Versus Long Bone

Chaichanasakul

Kang

Bezouglaia

et al. 2014

Journal of Periodontology

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Background Mandible (MB) and maxilla possess unique metabolic and functional properties and demonstrate discrete responses to homeostatic, mechanical, hormonal and developmental stimuli. Osteogenic potential of bone marrow stromal cells (BMSCs) differs between MB versus long bones (LB). Furthermore, MB versus LB derived osteoclasts (OCs) have disparate functional properties. Here, we explored the osteoclastogenic potential of rat MB versus LB marrow in vitro and in vivo under basal and stimulated conditions. Methods Bone marrow from rat MB and LB was cultured in osteoblastic or osteoclastic differentiation media. Tartrate resistant acid phosphatase (TRAP) staining, resorption pit assays, and real-time PCR were performed. Additionally, osmotic mini-pumps were implanted in animals, mandibles and tibiae were isolated and multinucleated cells (MNCs) were measured. Results MB versus LB marrow cultures differentiated with RANKL and M-CSF produced more TRAP+ multinucleated cells (MNCs) and greater resorptive area. To explore MB versus LB BMSC supported osteoclastogenesis, confluent BMSCs were cultured with parathyroid hormone (PTH), 1α,25-dihydroxyvitaminD3 (1,25D3), or PTH+1,25D3. 1,25D3 or PTH+1,25D3 treated LB BMSCs expressed significantly higher RANKL and lower OPG mRNA and increased RANKL:OPG ratio. When whole marrow was cultured with PTH+1,25D3, more TRAP+ MNCs were seen in LB versus MB cultures. Ultimately, rats were infused with PTH+1,25D3 and MB versus tibia MNCs were measured. Hormonal stimulation increased osteoclastogenesis in both MB and tibia. However, higher TRAP+ MNC numbers were observed in tibia versus MB under basal and hormonal stimulation. Conclusions Collectively, our data illustrate differences both on osteoclastogenic potential and OC numbers of MB versus LB marrow.

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“…Clinical parameters are still considered the gold‐standard outcomes when monitoring the results from any periodontal therapy. However, in search of a better understanding of periodontal diseases, microbiologic 5 and host‐related 6 aspects also have been studied. Nitrite is among them (Fig.…”

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confidence: 99%