Future Leads: Natural Products as Anti-infective Agent

Marine organisms as potential sources of natural products for the prevention and treatment of malaria

“…103 A family of monoterpene-quinones, xestoquinone, and alisiaquinones, showed promising antimalarial activities. Xestoquinone (110) was obtained from a Vanuatu Pacic marine sponge Xestospongia sp., while alisiaquinone A (111), B (112), C (113), and alisiaquinol (114) were extracted from an unidenti-ed deep-water Caledonian sponge. Xestoquinone was a selective active inhibitor of a protein kinase (Pfnek-1) of P. falciparum with IC 50 = 1 mM.…”

“…Furthermore, ( S )-curcuphenol ( 120 ) is a sesquiterpene phenol isolated from the Jamaican sponge Didiscus oxeata , displayed in vitro activity against D6 and W2 strains of P. falciparum (MIC = 0.017 and 0.008 μM, respectively). 110 (2 Z ,6 R ,8 R ,9 E )[3-ethyl-5-(2-ethyl-hex-3-enyl)-6-methyl-5 H -furan-2-ylidene]-acetic acid methyl ester ( 121 ), a polyketide was isolated from Plakortis angulospiculatus sponge. It showed mild antimalarial activity against D6 and W2 P. falciparum colonies (IC 50 = 6.6 nM on both strains).…”