Marine organisms as potential sources of natural products for the prevention and treatment of malaria

Negm, Walaa A.; Ezzat, Shahira M.; Zayed, Ahmed

doi:10.1039/d2ra07977a

Cited by 6 publications

(3 citation statements)

References 148 publications

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Section: Discussionmentioning

confidence: 65%

“…Among them, the biological activities of sponges, algae, and bacteria have been studied the most, and have shown anti-tumor and anti-bacterial effects [ 29 , 30 ]. There are relatively few drugs from corals [ 31 ]. Therefore, our study demonstrates that epi -oxyzoanthamine isolated from zoanthid has good anti-dermatological potential, especially in the treatment of atopic dermatitis.…”

Section: Discussionmentioning

confidence: 99%

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Anti-Atopic Dermatitis Activity of Epi-Oxyzoanthamine Isolated from Zoanthid

Hsu

Cheng

et al. 2023

Marine Drugs

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Atopic dermatitis (AD, eczema) is a condition that causes dry, itchy, and inflamed skin and occurs most frequently in children but also affects adults. However, common clinical treatments provide limited relief and have some side effects. Therefore, there is a need to develop new effective therapies to treat AD. Epi-oxyzoanthamine is a small molecule alkaloid isolated from Formosan zoanthid. Relevant studies have shown that zoanthamine alkaloids have many pharmacological and biological activities, including anti-lymphangiogenic functions. However, there are no studies on the use of epi-oxyzoanthamine on the skin. In this paper, epi-oxyzoanthamine has been shown to have potential in the treatment of atopic dermatitis. Through in vitro studies, it was found that epi-oxyzoanthamine inhibited the expression of cytokines in TNF-α/IFN-γ-stimulated human keratinocyte (HaCaT) cells, and it reduced the phosphorylation of MAPK and the NF-κB signaling pathway. Atopic dermatitis-like skin inflammation was induced in a mouse model using 2,4-dinitrochlorobenzene (DNCB) in vivo. The results showed that epi-oxyzoanthamine significantly decreased skin barrier damage, scratching responses, and epidermal hyperplasia induced by DNCB. It significantly reduced transepidermal water loss (TEWL), erythema, ear thickness, and spleen weight, while also increasing surface skin hydration. These results indicate that epi-oxyzoanthamine from zoanthid has good potential as an alternative medicine for treating atopic dermatitis or other skin-related inflammatory diseases.

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Section: Discussionmentioning

confidence: 65%

Section: Discussionmentioning

confidence: 99%

Anti-Atopic Dermatitis Activity of Epi-Oxyzoanthamine Isolated from Zoanthid

Hsu

Cheng

et al. 2023

Marine Drugs

View full text Add to dashboard Cite

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“…Marine bioactive compounds, like alkaloids, peptides, terpenes, polysaccharides, quinones, etc. have been proven active in diseases like cancer, 1,2 malaria, 3 infection, 4,5 etc. Among them, antimicrobial peptides (AMPs) are promising alternatives to solve the antibiotic crisis.…”

Section: Introductionmentioning

confidence: 99%