Northeast China lies in the transition zone from the humid monsoonal to the arid continental climate, with diverse ecosystems and agricultural land highly susceptible to climate change. This region has experienced significant greening in the past three decades, but future trends remain uncertain. In this study, we provide a quantitative assessment of how vegetation, indicated by the leaf area index (LAI), will change in this region in response to future climate change. Based on the output of eleven CMIP6 global climates, Northeast China is likely to get warmer and wetter in the future, corresponding to an increase in regional LAI. Under the medium emissions scenario (SSP245), the average LAI is expected to increase by 0.27 for the mid-century (2041–2070) and 0.39 for the late century (2071–2100). Under the high emissions scenario (SSP585), the increase is 0.40 for the mid-century and 0.70 for the late century, respectively. Despite the increase in the regional mean, the LAI trend shows significant spatial heterogeneity, with likely decreases for the arid northwest and some sandy fields in this region. Therefore, climate change could pose additional challenges for long-term ecological and economic sustainability. Our findings could provide useful information to local decision makers for developing effective sustainable land management strategies in Northeast China.