Future clinical applicability of optical coherence tomography angiography

Chua, Jacqueline; Tan, Bingyao; Ang, Marcus; Nongpiur, Monisha E.; Tan, Anna; Najjar, Raymond P.; Miléa, Dan

doi:10.1111/cxo.12854

Cited by 38 publications

(33 citation statements)

References 129 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…vasculature in the macular and peripapillary regions [25][26][27]. Due to the limitations of the analysis software, only super cial vascular plexus in the macular region could be quantitatively analyzed in our study.…”

Section: Octa Has Been Widely Used To Analyze the Detailed Characterimentioning

confidence: 99%

Evaluation of retinal and choroidal variations in thyroid-associated ophthalmopathy using optical coherence tomography angiography

Qin

Cheng

et al. 2020

Preprint

View full text Add to dashboard Cite

Background: To investigate the difference in retinal nerve fiber layer (RNFL) thickness, choroidal thickness (CT) and superficial retinal vessels between thyroid-associated ophthalmopathy (TAO) patients and healthy controls. To identify the potential influencing factors for these parameters and evaluate their diagnostic abilities in TAO.Methods: 20 active TAO patients, 33 inactive TAO patients and 29 healthy participants were enrolled. TAO patients were divided according to the clinical activity score (CAS). RNFL thickness and CT were measured by HD-OCT, while foveal avascular zone (FAZ), vascular density and perfusion density were measured by optical coherence tomography angiography (OCTA). SPSS software was used for statistical analysis.Results: Active TAO patients had thinner RNFL thickness than the other two groups (P<0.001, P<0.001). Both active and inactive TAO patients had significantly higher CT in the macular region (all P<0.05). The FAZ area in the active TAO group was significantly larger than the other two groups (P=0.045, P=0.001). The inactive TAO group had significantly higher vascular density than the other two groups (all P<0.05). With regard to the perfusion density, significant differences were observed in the temporal and inferior areas (P=0.045, P=0.001), as well as the average values (P=0.032). The FAZ area was positively correlated with intraocular pressure (r=0.274, P=0.013), while it was negatively correlated with axial length (r=-0.344, P=0.002). The vascular density and perfusion density were not significantly correlated with different clinical variables (all P>0.05). The AUC analysis indicated these parameters also exhibited a significant discriminatory power in TAO diagnosis.Conclusions: TAO patients had significant variations in RNFL thickness, choroidal thickness, FAZ area and superficial retinal vessels. These parameters appeared to be potential adjuncts in the evaluation of TAO patients.

show abstract

Section: Octa Has Been Widely Used To Analyze the Detailed Characterimentioning

confidence: 99%

Evaluation of retinal and choroidal variations in thyroid-associated ophthalmopathy using optical coherence tomography angiography

Qin

Cheng

et al. 2020

Preprint

View full text Add to dashboard Cite

show abstract

“…[4] Optical coherence tomography angiography (OCTA) is a recent innovation that allows for further quanti cation of the retinal microvasculature and visualization of capillaries measuring 5-15 µm in diameter, which may be more representative of the entire microvascular network. [5,6] Thus, the OCTA may be a potential non-invasive optical imaging tool to determine the presence and role of microvascular dysfunction in AD and cognitive impairment.…”

Section: Introductionmentioning

confidence: 99%

“…Furthermore, OCTA is capable of measuring retinal capillary beds at distinct depths, separating the super cial capillary plexuses (SCP) and deep capillary plexuses (DCP), each re ecting the metabolic demand of particular neuronal layers. [5] In AD, the tissue of interest is the inner retinal layer, as re ected by the loss of retinal ganglion cells, [7,8] thinning of the retinal nerve bre layer thickness and ganglion cell layer thickness, [9] and deposition of β-amyloid (Aβ) plaques. [10] While there are a few OCTA studies investigating AD, there have been mixed conclusions.…”

Section: Introductionmentioning

confidence: 99%

Retinal Microvascular Alterations in Alzheimer’s Disease and Mild Cognitive Impairment

Chua

et al. 2020

Preprint

Self Cite

View full text Add to dashboard Cite

Background: The retina and brain share many neuronal and vasculature characteristics developmentally and potential biomarkers may be present in the retina. We investigated the retinal microvasculature in Alzheimer’s disease (AD) and mild cognitive impairment (MCI) using optical coherence tomography angiography (OCTA).Methods: In this cross-sectional study, 24 AD participants, 37 MCI participants, and 29 controls were diagnosed according to internationally accepted criteria. OCTA images of the superficial and deep capillary plexus (SCP, DCP) of the retinal microvasculature were obtained using a commercial OCTA system (Zeiss Cirrus HD-5000 with AngioPlex, Carl Zeiss Meditec, Dublin, CA). The main outcome measures were vessel density (VD) and fractal dimension (FD) in the SCP and DCP within a 2.5-mm ring around the fovea were compared between groups. Perfusion density of large vessels and foveal avascular zone (FAZ) area were additional outcome parameters.Results: Age, gender and race did not differ among groups. However, there was a significant difference in diabetes status (P=0.039), and systolic blood pressure (P=0.008) among the groups. After adjusting for confounders, AD participants showed significantly decreased VD in SCP and DCP (P = 0.005 and P = 0.016, respectively) and decreased FD in SCP (P = 0.008), compared to controls. MCI participants showed significantly decreased VD and FD only in SCP (P = 0.005 and P < 0.001, respectively) and not the DCP (P > 0.05) compared with controls. There was no difference in the OCTA variables between AD and MCI (P > 0.05). Perfusion density of large vessels and FAZ area did not differ significantly between groups (P > 0.05).Conclusions and relevance: Eyes of patients with AD have significantly reduced macular VD in both plexuses whereas MCI participants only showed reduction in the superficial plexus. Changes in the retinal microvasculature and capillary network may mirror small vessel cerebrovascular changes in AD.

show abstract

“…Optical coherence tomography technology has developed rapidly over the past decade [1]. The advent of ocular coherence tomography angiography (OCTA) in recent years has provided clinicians and scientists with a non-invasive and quick method of obtaining ocular angiographic images of vascular structures [2]. OCTA has been widely employed in studying a host of posterior segment pathology such as diabetic retinopathy, retina vein occlusions, retina artery occlusions, choroidal neovascularization, and optic neuropathies [3,4].…”

Section: Introductionmentioning

confidence: 99%

Clinical Applications of Optical Coherence Angiography Imaging in Ocular Vascular Diseases

2019

Self Cite

View full text Add to dashboard Cite

Optical coherence tomography angiography (OCTA) provides us with a non-invasive and efficient means of imaging anterior and posterior segment vasculature in the eye. OCTA has been shown to be effective in imaging diseases such as diabetic retinopathy; retinal vein occlusions; retinal artery occlusions; ocular ischemic syndrome; and neovascularization of the iris. It is especially useful with depth-resolved imaging of the superficial, intermediate, and deep capillary plexi in the retina, which enables us to study and closely monitor disease progression and response to treatment. With further advances in technology, OCTA has the potential to become a more widely used tool in the clinical setting and may even supersede ocular angiography in some areas.

show abstract

Future clinical applicability of optical coherence tomography angiography

Cited by 38 publications

References 129 publications

Evaluation of retinal and choroidal variations in thyroid-associated ophthalmopathy using optical coherence tomography angiography

Evaluation of retinal and choroidal variations in thyroid-associated ophthalmopathy using optical coherence tomography angiography

Retinal Microvascular Alterations in Alzheimer’s Disease and Mild Cognitive Impairment

Clinical Applications of Optical Coherence Angiography Imaging in Ocular Vascular Diseases

Contact Info

Product

Resources

About