Fusobacterium nucleatum – Friend or foe?

Stokowa-Sołtys, Kamila; Wojtkowiak, Kamil; Jagiełło, Karolina

doi:10.1016/j.jinorgbio.2021.111586

Cited by 42 publications

(34 citation statements)

References 140 publications

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“…176,177 It was found that the interaction of F. nucleatum Fap-2 (fibroblast activation protein 2), and Gal or GalNAc was implicated in numerous diseases, including IBD and cancer. 178 These findings should trigger further investigations to design DDS to block Fap-2/Gal or Fap-2/GalNAc interaction. Similarly, it was demonstrated that blocking the interaction of Escherichia coli FimH lectin with epithelial glycan prevents mucosal inflammation associated with CD.…”

Section: Mucusmentioning

confidence: 99%

Advances in the treatment of inflammatory bowel disease: Focus on polysaccharide nanoparticulate drug delivery systems

Hadji

Bouchemal

2022

Advanced Drug Delivery Reviews

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Section: Mucusmentioning

confidence: 99%

Advances in the treatment of inflammatory bowel disease: Focus on polysaccharide nanoparticulate drug delivery systems

Hadji

Bouchemal

2022

Advanced Drug Delivery Reviews

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“…It is noteworthy that certain miRNAs, such as miRNA515-5p for F. nucleatum , have been demonstrated to be able to enter bacterial cells and induce gene expression, facilitating bacterial growth and progression of tissue damages [ 70 , 71 ]. This capability is very important for the bacterial pathogenicity, and F. nucleatum is currently under consideration for its ability to induce local and distant damages, including cancers [ 70 , 72 , 73 , 74 ]. In fact, it has been positively related to periodontitis but also to pancreatic and colic cancers [ 75 ].…”

Section: Discussionmentioning

confidence: 99%

Association between Vitamin D Receptor Gene Polymorphisms and Periodontal Bacteria: A Clinical Pilot Study

Cafiero¹,

Grippaudo

Dell’Aquila

et al. 2022

Biomolecules

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Background: Periodontitis is an inflammatory disease caused by microorganisms involving the supporting tissues of the teeth. Gene variants may influence both the composition of the biofilm in the oral cavity and the host response. The objective of the study was to investigate the potential correlations between the disease susceptibility, the presence and the quantity of periodontopathogenic oral bacterial composition and the VDR gene polymorphisms. Methods: Fifty (50) unrelated periodontal patients and forty-one (41) healthy controls were selected for genomic DNA extraction. DNA concentration was measured and analyzed. The periodontopathogenic bacterial species were identified and quantified using a Real Time PCR performed with species-specific primers and probes. Results: Genotype distribution showed a different distribution between the groups for BsmI rs1544410 genotypes (p = 0.0001) with a prevalence of the G(b) allele in periodontal patients (p = 0.0003). Statistical significance was also found for VDR TaqI rs731236 (p ≤ 0.00001) with a prevalence of the T(T) allele in periodontal patients (p ≤ 0.00001). The average bacterial copy count for the periodontitis group was significantly higher than that of control group. Dividing patients into two groups based on high or low bacterial load, FokI rs2228570 T allele (f) was statistically more represented in patients with high bacterial load. Conclusions: The findings of the study suggest the involvement of the VDR gene BsmI and TaqI polymorphisms in periodontal disease, while FokI and BsmI may be involved in determining an increased presence of periodontopathogens.

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“…In the oral environment, on the one hand, F. nucleatum could establish a symbiotic relationship with the host under a healthy state ( Dukka et al, 2021 ). On the other hand, F. nucleatum could destroy the balance as a pathogen, interacting with other pathogens and leading to severe oral diseases ( Lamont et al, 2018 ; Stokowa-Soltys et al, 2021 ). Existing research has explained how F. nucleatum affects the initiation and development of periodontal diseases to a large extent, but few studies have focused on the relationship between peri-implant diseases and F. nucleatum .…”

Section: Introductionmentioning

confidence: 99%

Fusobacterium nucleatum: The Opportunistic Pathogen of Periodontal and Peri-Implant Diseases

Chen

Shi

et al. 2022

Front. Microbiol.

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Peri-implant diseases are considered to be a chronic destructive inflammatory destruction/damage occurring in soft and hard peri-implant tissues during the patient’s perennial use after implant restoration and have attracted much attention because of their high incidence. Although most studies seem to suggest that the pathogenesis of peri-implant diseases is similar to that of periodontal diseases and that both begin with microbial infection, the specific mechanism of peri-implant diseases remains unclear. As an oral opportunistic pathogen, Fusobacterium nucleatum (F. nucleatum) has been demonstrated to be vital for the occurrence and development of many oral infectious diseases, especially periodontal diseases. More notably, the latest relevant studies suggest that F. nucleatum may contribute to the occurrence and development of peri-implant diseases. Considering the close connection between peri-implant diseases and periodontal diseases, a summary of the role of Fusobacterium nucleatum in periodontal diseases may provide more research directions and ideas for the peri-implantation mechanism. In this review, we summarize the effects of F. nucleatum on periodontal diseases by biofilm formation, host infection, and host response, and then we establish the relationship between periodontal and peri-implant diseases. Based on the above aspects, we discuss the importance and potential value of F. nucleatum in peri-implant diseases.

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Fusobacterium nucleatum – Friend or foe?

Cited by 42 publications

References 140 publications

Advances in the treatment of inflammatory bowel disease: Focus on polysaccharide nanoparticulate drug delivery systems

Advances in the treatment of inflammatory bowel disease: Focus on polysaccharide nanoparticulate drug delivery systems

Association between Vitamin D Receptor Gene Polymorphisms and Periodontal Bacteria: A Clinical Pilot Study

Fusobacterium nucleatum: The Opportunistic Pathogen of Periodontal and Peri-Implant Diseases

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