Advances in the treatment of inflammatory bowel disease: Focus on polysaccharide nanoparticulate drug delivery systems

Hadji, Hicheme; Bouchemal, Kawthar

doi:10.1016/j.addr.2021.114101

Cited by 49 publications

(41 citation statements)

References 322 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…It is well understood that IL-23 plays an essential role in Th cell polarization versus the Th17 subset, that secretes the pro inflammatory cytokine IL-17 and promotes inflammations. IL-23 is also able to activate IL-10 formation in naïve T-lymphocytes [51]. This also clarifies the relationship between IL-10 and IL-23 among COVID-19 patients.…”

Section: Discussionsupporting

confidence: 59%

Evaluation of Interleukin-23 and Creatine Kinase –MB (CK-MB) Levels in Acute Coronary Syndrome Patients with COVID-19 in Baghdad City

Yaseen¹,

Risan²,

Aubaid³

2022

View full text Add to dashboard Cite

Acute coronary syndrome (ACS) is considered a common cardiovascular disease, in which there is a blood supply reduction to the myocardium, mostly due to atherosclerosis in the coronary arteries. the present study was designed to detect serum markers in Acute coronary syndrome patients infected with COVID-19 in Baghdad Governorate, by evaluating the level of Interleukin-23(IL-23) and level of creatine kinase isoenzyme (CK-MB). Methods: A total of one hundred fifty participants were enrolled in the current study divided into three groups 50 patients with ACS and 50 ACS with COVID-19 patients, while 50 participants as apparently healthy controls. age and sex-matched as healthy controls were involved in the present study. The serum IL-23 and CK-MB levels were measured using an ELISA technique. Serum concentrations of IL-23 and CK-MB were significantly higher in ACS patients and ACS with COVID-19 patients compared to healthy controls (P≤0.01) also there was a highly significant difference at (P≥ 0.01) between ACS patients and ACS with COVID-19 patients. IL- 23 can be considered a biomarker for ACS patients and ACS with COVID-19 patients.

show abstract

Section: Discussionsupporting

confidence: 59%

Evaluation of Interleukin-23 and Creatine Kinase –MB (CK-MB) Levels in Acute Coronary Syndrome Patients with COVID-19 in Baghdad City

Yaseen¹,

Risan²,

Aubaid³

2022

View full text Add to dashboard Cite

show abstract

“…Next-generation sequencing technologies allow a deep characterization of the microbiota of IBD patients (Nishida et al, 2018). Evidence suggests that novel prebiotics mixtures derived from pectin could be tailored to ameliorate IBD symptoms as demonstrated in animal experiments and clinical research (Hadji & Bouchemal, 2022;Wei et al, 2016). Interestingly, pectin supplementation has been shown to aid maintain long term the benefits of fecal microbiota transplantation in ulcerative colitis patients (Wei et al, 2016).…”

Section: Introductionmentioning

confidence: 99%

Prebiotic potential of apple pomace and pectins from different apple varieties: Modulatory effects on key target commensal microbial populations

et al. 2022

View full text Add to dashboard Cite

“…These prebiotic mixtures could be tailored to target specific diseases such as IBD [15,16]. In addition, previous studies suggest the beneficial effects of pectin, arabinoxylan and oligosaccharides derived from these substrates to ameliorate IBD symptoms in clinical research [17][18][19].…”

Section: Introductionmentioning

confidence: 99%

Arabinoxylan and Pectin Metabolism in Crohn’s Disease Microbiota: An In Silico Study

Sabater

Calvete-Torre

Ruíz

et al. 2022

IJMS

View full text Add to dashboard Cite

Inflammatory bowel disease is a chronic disorder including ulcerative colitis and Crohn’s disease (CD). Gut dysbiosis is often associated with CD, and metagenomics allows a better understanding of the microbial communities involved. The objective of this study was to reconstruct in silico carbohydrate metabolic capabilities from metagenome-assembled genomes (MAGs) obtained from healthy and CD individuals. This computational method was developed as a mean to aid rationally designed prebiotic interventions to rebalance CD dysbiosis, with a focus on metabolism of emergent prebiotics derived from arabinoxylan and pectin. Up to 1196 and 1577 MAGs were recovered from CD and healthy people, respectively. MAGs of Akkermansia muciniphila, Barnesiella viscericola DSM 18177 and Paraprevotella xylaniphila YIT 11841 showed a wide range of unique and specific enzymes acting on arabinoxylan and pectin. These glycosidases were also found in MAGs recovered from CD patients. Interestingly, these arabinoxylan and pectin degraders are predicted to exhibit metabolic interactions with other gut microbes reduced in CD. Thus, administration of arabinoxylan and pectin may ameliorate dysbiosis in CD by promoting species with key metabolic functions, capable of cross-feeding other beneficial species. These computational methods may be of special interest for the rational design of prebiotic ingredients targeting at CD.

show abstract

Advances in the treatment of inflammatory bowel disease: Focus on polysaccharide nanoparticulate drug delivery systems

Cited by 49 publications

References 322 publications

Evaluation of Interleukin-23 and Creatine Kinase –MB (CK-MB) Levels in Acute Coronary Syndrome Patients with COVID-19 in Baghdad City

Evaluation of Interleukin-23 and Creatine Kinase –MB (CK-MB) Levels in Acute Coronary Syndrome Patients with COVID-19 in Baghdad City

Prebiotic potential of apple pomace and pectins from different apple varieties: Modulatory effects on key target commensal microbial populations

Arabinoxylan and Pectin Metabolism in Crohn’s Disease Microbiota: An In Silico Study

Contact Info

Product

Resources

About