Fusobacterium nucleatum and the Immune System in Colorectal Cancer

Borroni, Elena Monica; Qehajaj, Dorina; Farina, Floriana Maria; Yiu, Daniel; Bresalier, Robert S.; Chiriva‐Internati, Maurizio; Mirandola, Leonardo; Štifter, Sanja; Laghi, Luigi; Grizzi, Fabio

doi:10.1007/s11888-019-00442-2

Cited by 6 publications

(9 citation statements)

References 80 publications

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“…Another bacteria found enriched in CRCs compared to a matched normal tissue is Fusobacterium nucleatum and its presence in CRCs was also associated with poor prognosis [154]. Once again, human CRCs enriched for a Fusobacterium nucleatum infection associated with elevated levels of IL-17A along with TNF-α [155]. The Apc MIN mouse model infected with Fusobacterium nucleatum demonstrated that this infection promotes CRC development by acting on both tumour cells, enabling expansion of immune cells, and preventing T cell mediated immune killing of CRC cells [154,155].…”

Section: Influence Of Microbiota In Inflammation Associated With Colomentioning

confidence: 99%

“…Once again, human CRCs enriched for a Fusobacterium nucleatum infection associated with elevated levels of IL-17A along with TNF-α [155]. The Apc MIN mouse model infected with Fusobacterium nucleatum demonstrated that this infection promotes CRC development by acting on both tumour cells, enabling expansion of immune cells, and preventing T cell mediated immune killing of CRC cells [154,155]. Other bacteria implicated in the CRC development include Peptostreptococcus anaerobius, sulfidogenic bacteria [154,155], and Salmonella [156].…”

Section: Influence Of Microbiota In Inflammation Associated With Colomentioning

confidence: 99%

“…The Apc MIN mouse model infected with Fusobacterium nucleatum demonstrated that this infection promotes CRC development by acting on both tumour cells, enabling expansion of immune cells, and preventing T cell mediated immune killing of CRC cells [154,155]. Other bacteria implicated in the CRC development include Peptostreptococcus anaerobius, sulfidogenic bacteria [154,155], and Salmonella [156]. These results suggest that pathogenic bacterial infection can trigger a process of chronic inflammation resulting in accumulation of DNA damage because of repeated cycles of tissue damage and regeneration eventually resulting in tumour development.…”

Section: Influence Of Microbiota In Inflammation Associated With Colomentioning

confidence: 99%

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Role of Inflammation in Pathophysiology of Colonic Disease: An Update

Nasef

Mehta

2020

IJMS

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Diseases of the colon are a big health burden in both men and women worldwide ranging from acute infection to cancer. Environmental and genetic factors influence disease onset and outcome in multiple colonic pathologies. The importance of inflammation in the onset, progression and outcome of multiple colonic pathologies is gaining more traction as the evidence from recent research is considered. In this review, we provide an update on the literature to understand how genetics, diet, and the gut microbiota influence the crosstalk between immune and non-immune cells resulting in inflammation observed in multiple colonic pathologies. Specifically, we focus on four colonic diseases two of which have a more established association with inflammation (inflammatory bowel disease and colorectal cancer) while the other two have a less understood relationship with inflammation (diverticular disease and irritable bowel syndrome).

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Section: Influence Of Microbiota In Inflammation Associated With Colomentioning

confidence: 99%

Section: Influence Of Microbiota In Inflammation Associated With Colomentioning

confidence: 99%

Section: Influence Of Microbiota In Inflammation Associated With Colomentioning

confidence: 99%

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Role of Inflammation in Pathophysiology of Colonic Disease: An Update

Nasef

Mehta

2020

IJMS

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“…[25][26][27][29][30][31][32] Fusobacteria are also being recognized as having associations with CUC and colon cancer. 17,26,30,33 Reports of periappendicular inflammation in 80% of CUC patients and of beneficial effects of appendicectomy on disease activity in ulcerative proctitis 34,35 are suggestive. The Scandinavian study reporting that appendicectomy is protective of the development of CUC, but only when performed in adolescents and only for acute appendicitis, 36,37 offers more immunological insights.…”

mentioning

confidence: 99%

“…Fusobacteria are also being recognized as having associations with CUC and colon cancer 17,26,30,33 . Reports of periappendicular inflammation in 80% of CUC patients and of beneficial effects of appendicectomy on disease activity in ulcerative proctitis 34,35 are suggestive.…”

mentioning

confidence: 99%