2015
DOI: 10.1097/pcr.0000000000000075
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Fusion Transcripts That Characterize Malignancies of Salivary Gland Origin

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Cited by 4 publications
(3 citation statements)
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“…Mammary analog secretory carcinoma (MASC) of salivary gland origin is a recently described tumor that harbors a characteristic balanced chromosomal translocation, [1][2][3][4][5] t(12;15) (p13;q25) resulting in an ETV6-NTRK3 fusion 6 identical to that in secretory carcinoma of the breast. 7 Secretory carcinoma (SC), also known as juvenile breast cancer, is a very rare and distinctive variant of mammary ductal carcinoma, initially described by McDivitt and Stewart in patients ranging from 3 to 15 years.…”
Section: Introductionmentioning
confidence: 99%
“…Mammary analog secretory carcinoma (MASC) of salivary gland origin is a recently described tumor that harbors a characteristic balanced chromosomal translocation, [1][2][3][4][5] t(12;15) (p13;q25) resulting in an ETV6-NTRK3 fusion 6 identical to that in secretory carcinoma of the breast. 7 Secretory carcinoma (SC), also known as juvenile breast cancer, is a very rare and distinctive variant of mammary ductal carcinoma, initially described by McDivitt and Stewart in patients ranging from 3 to 15 years.…”
Section: Introductionmentioning
confidence: 99%
“…Recent identification of tumor-specifıc gene fusions and activated signaling pathways has helped advance understanding the pathobiology and classification of these tumors and raised the potential for developing targeted therapies. [1][2][3][4] Mammary analogue secretory carcinoma (MASC) is a rare salivary neoplasm that bears a significant histomorphologic, immunophenotypic, and molecular resemblance to secretory carcinoma of the breast. 3,5 The discovery of a t(12; 15) (p13; q25) translocation resulting in an ETV6-NTRK3 gene fusion in MASC, similar to what has been documented in secretory carcinoma of the breast, helped not only to further characterize this as a new salivary neoplasm but also to highlight the applicability of gene fusion studies in the identification and reclassification of tumors.…”
Section: Introductionmentioning
confidence: 99%
“…The differential diagnosis include pure carcinoma, spindle cell carcinoma, malignant fibrous histiocytoma (MFH), malignant melanoma, fibrosarcoma, leiomyosarcoma, osteosarcoma, liposarcoma and rhabdomyosarcoma. 8,9 Immunohistochemistry is instrumental in narrowing the differential diagnosis. 10,11 Sarcomas such as rhabdomyosarcoma or neurosarcoma show positivity for S-100 and HMB-45 with characteristic features on electron microscopy.…”
Section: Discussionmentioning
confidence: 99%