Fusion of microlitre water-in-oil droplets for simple, fast and green chemical assays

Chiu, Shih-Hao; Urban, Pawel L.

doi:10.1039/c5an00847f

Cited by 6 publications

(10 citation statements)

References 48 publications

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“…Notably, this reaction is frequently used to quantify vitamin C 40 and as a model reaction 41 in kinetic studies. The solution of 2,6-dichlorophenolindophenol in agarose hydrogel has a blue appearance.…”

Section: Three-dimensional Monitoring Of Reaction Frontsmentioning

confidence: 99%

Facile multi-dimensional profiling of chemical gradients at the millimetre scale

Chen

Hsieh

Hsu

et al. 2016

Analyst

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A vast number of conventional physicochemical methods are suitable for the analysis of homogeneous samples. However, in various cases, the samples exhibit intrinsic heterogeneity. Tomography allows one to record approximate distributions of chemical species in the three-dimensional space. Here we develop a simple optical tomography system which enables performing scans of non-homogeneous samples at different wavelengths. It takes advantage of inexpensive open-source electronics and simple algorithms. The analysed samples are illuminated by a miniature LCD/LED screen which emits light at three wavelengths (598, 547 and 455 nm, corresponding to the R, G, and B channels, respectively). On presentation of every wavelength, the sample vial is rotated by ∼180°, and videoed at 30 frames per s. The RGB values of pixels in the obtained digital snapshots are subsequently collated, and processed to produce sinograms. Following the inverse Radon transform, approximate quasi-three-dimensional images are reconstructed for each wavelength. Sample components with distinct visible light absorption spectra (myoglobin, methylene blue) can be resolved. The system was used to follow dynamic changes in non-homogeneous samples in real time, to visualize binary mixtures, to reconstruct reaction-diffusion fronts formed during the reduction of 2,6-dichlorophenolindophenol by ascorbic acid, and to visualize the distribution of fungal mycelium grown in a semi-solid medium.

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Section: Three-dimensional Monitoring Of Reaction Frontsmentioning

confidence: 99%

Facile multi-dimensional profiling of chemical gradients at the millimetre scale

Chen

Hsieh

Hsu

et al. 2016

Analyst

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“…Moreover, according to the differences in the density between the droplets and the medium in a continuous phase, dispersed droplets can move to the top or the bottom, which is referred to as creaming or sedimentation, respectively [1]. Many studies concerning emulsions appear in the literature, including recent reports on the coalescence of emulsion droplets [2,3], the monitoring of interfacial lipid oxidation in emulsions [4], an examination into the luminol chemiluminescence profiles of emulsions [5], and a determination of the electrostatic potential of droplets [6].…”

Section: Introductionmentioning

confidence: 99%

Development of Multiphoton Ionization Time-of-Flight Mass Spectrometry for the Detection of Small Emulsion Droplets

2018

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A system for measuring small oil droplets in an oil-in-water (O/W) emulsion was developed using multiphoton ionization time-of-flight mass spectrometry. In the present study, a capillary column with an inner diameter of 15 µm was used for sample introduction. Moreover, a compact microscopic system was constructed for observing an emulsion flowing through a capillary column. As a result, the length for sample introduction was shortened, which is preferable for the direct evaluation of an emulsion. Using this system, the minimum diameter of a detectable toluene droplet in an O/W emulsion was decreased to 1.7 µm. The present system could be used to evaluate the local microenvironment and stability of an emulsion.

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“…9,15 These ionic liquidbased micropatterns are limited to nonaqueous applications, which may not be suitable for analysis methodologies as they require water as a reaction medium. 11,16,19,20 An alternative approach to address the issue is to constrain the solvent within specified structures such as walls, reservoirs, or channels. However, these structures induce problems such as complex techniques of preparation, large dead volume, and poor control of hydrodynamic pressure.…”

Section: ■ Introductionmentioning

confidence: 99%

“…However, it is still challenging for low boiling point solvents, for example, acetone, ethanol, and hexane . Another suggested solution is to introduce nonvolatile solvent into the open system for micropattern formation, for example, ionic liquids. , These ionic liquid-based micropatterns are limited to nonaqueous applications, which may not be suitable for analysis methodologies as they require water as a reaction medium. ,,, An alternative approach to address the issue is to constrain the solvent within specified structures such as walls, reservoirs, or channels. However, these structures induce problems such as complex techniques of preparation, large dead volume, and poor control of hydrodynamic pressure. ,, …”

Section: Introductionmentioning

confidence: 99%

Breath-Taking Patterns: Discontinuous Hydrophilic Regions for Photonic Crystal Beads Assembly and Patterns Revisualization

Wang

Cui

et al. 2017

ACS Appl. Mater. Interfaces

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Surfaces patterned with hydrophilic and hydrophobic regions provide robust and versatile means for investigating the wetting behaviors of liquids, surface properties analysis, and producing patterned arrays. However, the fabrication of integral and uniform arrays onto these open systems remains a challenge, thus restricting them from being used in practical applications. Here, we present a simple yet powerful approach for the fabrication of water droplet arrays and the assembly of photonic crystal bead arrays based on hydrophilic-hydrophobic patterned substrates. Various integral arrays are simply prepared in a high-quality output with a low cost, large scale, and uniform size control. By simply taking a breath, which brings moisture to the substrate surface, complex hydrophilic-hydrophobic outlined images can be revisualized in the discontinuous hydrophilic regions. Integration of hydrogel photonic crystal bead arrays into the "breath-taking" process results in breath-responsive photonic crystal beads, which can change their colors upon a mild exhalation. This state-of-the-art technology not only provides an effective methodology for the preparation of patterned arrays but also demonstrates intriguing applications in information storage and biochemical sensors.

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Fusion of microlitre water-in-oil droplets for simple, fast and green chemical assays

Cited by 6 publications

References 48 publications

Facile multi-dimensional profiling of chemical gradients at the millimetre scale

Facile multi-dimensional profiling of chemical gradients at the millimetre scale

Development of Multiphoton Ionization Time-of-Flight Mass Spectrometry for the Detection of Small Emulsion Droplets

Breath-Taking Patterns: Discontinuous Hydrophilic Regions for Photonic Crystal Beads Assembly and Patterns Revisualization

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