Fusiform Gyrus Volume Reduction and Facial Recognition in Chronic Schizophrenia

Onitsuka, Toshiaki; Shenton, Martha E.; Kasai, Kiyoto; Nestor, Paul G.; Toner, Sarah; Kikinis, Ron; Jólesz, Ferenc A.; McCarley, Robert W.

doi:10.1001/archpsyc.60.4.349

Cited by 136 publications

(89 citation statements)

References 51 publications

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“…The protocols for diagnosis and clinical evaluations have been previously described (Kubicki et al 2002(Kubicki et al , 2003Onitsuka et al 2003). All subjects met the following criteria: aged 18 to 55, IQ greater than 75, right handed (Oldfield 1971), no history of seizures or head trauma with loss of consciousness or a neurological disorder, and no alcohol or drug dependence in the past 5 years.…”

Section: Methods and Materials Subjectsmentioning

confidence: 99%

Fornix Integrity and Hippocampal Volume in Male Schizophrenic Patients

Kuroki

Kubicki

Nestor

et al. 2006

Biological Psychiatry

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138

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Background-The hippocampus has been shown to be abnormal in schizophrenia. The fornix is one of the main fiber tracts connecting the hippocampus with other brain regions. Few studies have evaluated the fornix in schizophrenia, however. A focus on fornix abnormalities and their association with hippocampal abnormalities might figure importantly in our understanding of the pathophysiology of schizophrenia.

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Section: Methods and Materials Subjectsmentioning

confidence: 99%

Fornix Integrity and Hippocampal Volume in Male Schizophrenic Patients

Kuroki

Kubicki

Nestor

et al. 2006

Biological Psychiatry

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138

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“…Several studies have reported that schizophrenia patients show deficits in facial processing 21 . It has been hypothesized that the FF might be the central brain region underlying abnormal facial recognition in schizophrenia 22 . The studies reviewed here provided convergent results of decreased rCBF in the FF, in support to this hypothesis.…”

Section: Discussionmentioning

confidence: 99%

Arterial spin labeling in patients with schizophrenia: a systematic review

Guimarães¹,

Machado‐de‐Sousa²,

Crippa³

et al. 2016

Arch. Clin. Psychiatry (São Paulo)

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Background: Neuroimaging studies are an invaluable source of information about the physiopathology of schizophrenia. Arterial spin labeling (ASL) is a new magnetic resonance technique (MRI) that is able to effectively evaluate brain function without the use of radiation. Objective: To make a systematic review of studies using ASL to compare resting-state regional cerebral blood flow (rCBF) patterns in patients with schizophrenia and healthy controls. Methods: Original articles were searched for on PubMed, Scopus, Web of Science and PsycINFO electronic databases. The search terms used were 'arterial' , 'spin' , 'labeling' , and 'schizophrenia' . Only studies comparing resting-state rCBF were included, a qualitative synthesis was then performed. Results: Ten articles were included in the review among a total of 22. Decreased rCBF in schizophrenia patients was described in the anterior cingulate, cuneus, fusiform gyrus, frontal lobe, left middle frontal gyrus, inferior frontal gyrus, lingual gyrus, middle occipital gyrus, and parietal lobe. The putamen was the only region with increased rCBF in schizophrenia. Discussion: The evidence of the studies reviewed lends support to the concept of hipofrontality in schizophrenia. rCBF alterations were found in regions classically associated with schizophrenia. ASL seems to be valid, and reliable tool to assess schizophrenia.

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“…Because right fusiform gyrus is involved in true and false memories (especially for specific long-term memory of persons and scenes), we hypothesized that right fusiform gyrus volume would be associated with both short-and long-term true and false memories. Unlike the hippocampus, right fusiform gyrus volume was expected to be associated negatively with true memory and positively with false memory based on previous results (Dickey et al 2003;Nestor et al 2007;Onitsuka et al 2003;Paz-Alonso et al 2013). Finally, we hypothesized that parahippocampal gyrus volume would be associated positively with true memory and negatively associated with false memory.…”

Section: Introductionmentioning

confidence: 91%

“…For example, schizophrenic patients with more severe clinical symptoms were found, in separate studies, to have smaller volumes of right fusiform gyrus (Dickey et al 2003) and less false memory (Paz-Alonso et al 2013), suggesting that right fusiform gyrus volume might be associated positively with false memory. In terms of true memory, smaller volumes of the right fusiform gyrus have been associated with better delayed face memory in middle-aged adult patients with schizophrenia (Nestor et al 2007;Onitsuka et al 2003), but worse delayed face memory in children with autism (Trontel et al 2013). In further support of the connection between the right fusiform volume and face memory, researchers found negative correlations between right posterior fusiform gyrus volumes and N170 amplitudes in response to images of faces in schizophrenia patients (Onitsuka et al 2006).…”

Section: Introductionmentioning

confidence: 95%

“…Structural neuroimaging studies also showed that right fusiform gyrus volume was associated with memory and illusion (Dickey et al 2003;Nestor et al 2007;Onitsuka et al 2003Onitsuka et al , 2006Trontel et al 2013). For example, schizophrenic patients with more severe clinical symptoms were found, in separate studies, to have smaller volumes of right fusiform gyrus (Dickey et al 2003) and less false memory (Paz-Alonso et al 2013), suggesting that right fusiform gyrus volume might be associated positively with false memory.…”

Section: Introductionmentioning

confidence: 97%

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Hippocampal size is related to short-term true and false memory, and right fusiform size is related to long-term true and false memory

et al. 2015

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Hippocampal size is related to short-term true and false memory, and right fusiform size is related to long-term true and false memory Abstract There is a keen interest in identifying specific brain regions that are related to individual differences in true and false memories. Previous functional neuroimaging studies showed that activities in the hippocampus, right fusiform gyrus, and parahippocampal gyrus were associated with true and false memories, but no study thus far has examined whether the structures of these brain regions are associated with short-term and long-term true and false memories. To address that question, the current study analyzed data from 205 healthy young adults, who had valid data from both structural brain imaging and a misinformation task. In the misinformation task, subjects saw the crime scenarios, received misinformation, and took memory tests about the crimes an hour later and again after 1.5 years. Results showed that bilateral hippocampal volume was associated with short-term true and false memories, whereas right fusiform gyrus volume and surface area were associated with long-term true and false memories. This study provides the first evidence for the structural neural bases of individual differences in short-term and long-term true and false memories.

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Fusiform Gyrus Volume Reduction and Facial Recognition in Chronic Schizophrenia

Abstract: These results suggest that neuroanatomic FG abnormalities underlie at least some of the deficits associated with facial recognition in schizophrenia.

Cited by 136 publications

References 51 publications

Fornix Integrity and Hippocampal Volume in Male Schizophrenic Patients

Fornix Integrity and Hippocampal Volume in Male Schizophrenic Patients

Arterial spin labeling in patients with schizophrenia: a systematic review

Hippocampal size is related to short-term true and false memory, and right fusiform size is related to long-term true and false memory

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