Hippocampal size is related to short-term true and false memory, and right fusiform size is related to long-term true and false memory

Zhu, Bi; Chen, Chuansheng; Loftus, Elizabeth F.; He, Qinghua; Lei, Xin; Dong, Qi; Lin, Chongde

doi:10.1007/s00429-015-1145-1

Cited by 3 publications

(3 citation statements)

References 57 publications

(95 reference statements)

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“…For participants with S2, atrophy in paracentral, superior frontal regions were associated with lower limb movement and cognitive impairment in working memory 57,58 . Notably, the fusiform plays a critical role in cognitive decline associated with language comprehension 59 , visual processing 60,61 , and long-term memory 62 . Atrophy in this region could contribute to Alzheimer's disease and semantic dementia 63,64 .…”

Section: Discussionmentioning

confidence: 99%

Identification of distinct trajectories in preclinical type 2 diabetes and their associations with outcomes

Huang

2024

Preprint

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Type 2 Diabetes Mellitus (T2DM) is increasingly prevalent and significantly impacts patients' lives. However, the phenotypic and genetic heterogeneity of the preclinical stage of T2DM, along with the subsequent effects on various clinical outcomes, remain unclear, impeding progress in disease screening and prevention. To address this gap, we employed a robust machine learning algorithm (Subtype and Stage Inference, SuStaIn) with cross-sectional clinical data from the UK Biobank (20,305 preclinical-T2DM participants and 20,305 controls) to identify underlying subtypes and their progression trajectories for preclinical-T2DM. Our analysis revealed one subtype distinguished by elevated circulating leptin levels and decreased leptin receptor levels, coupled with increased BMI, diminished lipid metabolism, and heightened susceptibility to psychiatric conditions such as anxiety disorder, depression disorder, and bipolar disorder. Conversely, individuals in the second subtype manifested typical abnormalities in glucose metabolism, including rising glucose and HbA1c levels, with observed correlations with neurodegenerative disorders. Over ten-year follow-up observations of these individuals reveal differential deterioration in brain and heart organs, and statistically significant difference in disease risk and clinical outcomes between the two subtypes. Our findings indicate a heterogenous pathobiological basis underlying the progression of preclinical-T2DM, with clinical implications for understanding human health from a multiorgan perspective, and improving disease risk screening, prediction, and prevention efforts.

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Section: Discussionmentioning

confidence: 99%

Identification of distinct trajectories in preclinical type 2 diabetes and their associations with outcomes

Huang

2024

Preprint

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“…To mimic real-life situations, the current study had participants read post-event misinformation three hours after seeing multiple events, and take the memory test one day later. However, the time interval between encoding and retrieval may affect memory traces in the hippocampus to produce false memory 65 – 67 . Future studies should explore changes in hippocampal representations at longer time intervals (e.g., weeks or months) and their effects on misinformation false memory.…”

Section: Discussionmentioning

confidence: 99%

“…To define anatomical region of interest (ROI) in each participant’s native space, we segmented the structural image for each participant using FreeSurfer (version 6.0). Due to the key role of the hippocampus in false memory 13 , 20 , 22 , 65 , we defined bilateral hippocampus based on its anatomical structure. The hippocampus was collapsed across both hemispheres.…”

Section: Methodsmentioning

confidence: 99%

Cross-stage neural pattern similarity in the hippocampus predicts false memory derived from post-event inaccurate information

Shao

Chen

et al. 2023

Nat Commun

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The misinformation effect occurs when people’s memory of an event is altered by subsequent inaccurate information. No study has systematically tested theories about the dynamics of human hippocampal representations during the three stages of misinformation-induced false memory. This study replicates behavioral results of the misinformation effect, and investigates the cross-stage pattern similarity in the hippocampus and cortex using functional magnetic resonance imaging. Results show item-specific hippocampal pattern similarity between original-event and post-event stages. During the memory-test stage, hippocampal representations of original information are weakened for true memory, whereas hippocampal representations of misinformation compete with original information to create false memory. When false memory occurs, this conflict is resolved by the lateral prefrontal cortex. Individuals’ memory traces of post-event information in the hippocampus predict false memory, whereas original information in the lateral parietal cortex predicts true memory. These findings support the multiple-trace model, and emphasize the reconstructive nature of human memory.

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False recall is associated with larger caudate in males but not in females

Shao,

Li,

Wang

et al. 2024

Memory

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Hippocampal size is related to short-term true and false memory, and right fusiform size is related to long-term true and false memory

Cited by 3 publications

References 57 publications

Identification of distinct trajectories in preclinical type 2 diabetes and their associations with outcomes

Identification of distinct trajectories in preclinical type 2 diabetes and their associations with outcomes

Cross-stage neural pattern similarity in the hippocampus predicts false memory derived from post-event inaccurate information

False recall is associated with larger caudate in males but not in females

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