Fused-filament 3D printing (3DP) for fabrication of tablets

Abstract

25The use of fused-filament 3D printing (FF 3DP) 30A final drug-loading of 0.29% w/w was achieved. Tablets of PVA/Fluorescein (10 mm 31 diameter) were printed using a 3D printer. It was found that changing the degree of

An investigation into the use of polymer blends to improve the printability of and regulate drug release from pharmaceutical solid dispersions prepared via fused deposition modeling (FDM) 3D printing

“…It was reported in the literature that the drug loading efficiency of the FDM 3D printed samples prepared by passive diffusion of the drug from its organic solution into the readymade placebo PVA filaments was often lower than the theoretical value by more than 15% [8,32,33]. Using a high printing temperature also can lead to unsatisfactory loading efficiency due to the thermal degradation of the drug [8,32,33].…”

“…Using a high printing temperature also can lead to unsatisfactory loading efficiency due to the thermal degradation of the drug [8,32,33]. A temperature of 150 ˚C was used in this study during the FDM printing.…”

Adaptation of pharmaceutical excipients to FDM 3D printing for the fabrication of patient-tailored immediate release tablets

“…The potential of FDM 3D printing incorporating drugs into commercially available filaments (Goyanes et al, 2014a;Goyanes et al, 2014b;Goyanes et al, 2015b;Skowyra et al, 2015) has been explored previously. Nonetheless, all those studies highlighted several challenges involved in employing printing technique for pharmaceutical applications.…”

“…Nonetheless, all those studies highlighted several challenges involved in employing printing technique for pharmaceutical applications. The use of elevated temperatures (185-220 • C) and limited drug loading (0.063-9.5% w/w (Goyanes et al, 2014a;Goyanes et al, 2014b;Goyanes et al, 2015b;Skowyra et al, 2015) renders it less suitable for many drugs particularly thermo-labile ones. FDM 3D printing has been also restricted to a number of biodegradable thermoplastic polymers such as polylactic acid (PLA) (Sandler et al, 2014) and polyvinyl alcohol (PVA) (Goyanes et al, 2014a;Goyanes et al, 2014b;Goyanes et al, 2015b;Skowyra et al, 2015) in comparison to a wide variety of choices for conventional tabletting.…”

“…FDM 3D printing has been also restricted to a number of biodegradable thermoplastic polymers such as polylactic acid (PLA) (Sandler et al, 2014) and polyvinyl alcohol (PVA) (Goyanes et al, 2014a;Goyanes et al, 2014b;Goyanes et al, 2015b;Skowyra et al, 2015) in comparison to a wide variety of choices for conventional tabletting. Despite the attractive properties of PVA (Morita et al, 2000) and PLA (Hamad et al, 2016), the use of high polymer ratio in combination with the need for high molecular weight of the polymers generates polymeric matrices with limited porosity, thus resulting in extended drug release patterns (Goyanes et al, 2014a;Goyanes et al, 2014b;Goyanes et al, 2015a;Goyanes et al, 2015b;Sandler et al, 2014;Skowyra et al, 2015).…”