Fusaristatins D–F and (7S,8R)-(−)-chlamydospordiol from Fusarium sp. BZCB-CA, an endophyte of Bothriospermum chinense

Ariantari, Ni Putu; Frank, Mary Margaret; Gao, Ying; Stuhldreier, Fabian; Kiffe-Delf, Anna-Lene; Hartmann, Rudolf; Höfert, Simon-Patrick; Janiak, Christoph; Wesselborg, Sebastian; Müller, Werner; Kalscheuer, Rainer; Liu, Zhen; Proksch, Peter

doi:10.1016/j.tet.2021.132065

Cited by 6 publications

(6 citation statements)

References 48 publications

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“…Bikaverin (116) was found to have anti-E. coli and antifungal (P. notatum, Alternaria humicola, and A. flavus) activity [48,62,63]. Lateropyrone (117) was the same SM as F. acuminatum, F. lateritium, and F. tricinctum and displayed good antibacterial activity against B. subtilis, S. aureus, S. pneumoniae, methicillin-resistant S. aureus, Mycobacterium tuberculosis, and vancomycin-resistant of E. faecalis and significant inhibitory activity towards the growth of C. albicans [64][65][66][67]. BE-29,602 (118) was a novel antibiotic of the papulacandin family, showing good activity against C. albicans, S. cerevisiae, S. pombe with MIC values < 1 µg/mL and moderate activity against B. subtilis and P. chrysogenum with the MIC values < 8 µg/mL [44,68].…”

Section: Both Antibacterial and Antifungal Secondary Metabolitesmentioning

confidence: 99%

Fusarium-Derived Secondary Metabolites with Antimicrobial Effects

Huang

Zhu

et al. 2023

Molecules

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Fungal microbes are important in the creation of new drugs, given their unique genetic and metabolic diversity. As one of the most commonly found fungi in nature, Fusarium spp. has been well regarded as a prolific source of secondary metabolites (SMs) with diverse chemical structures and a broad spectrum of biological properties. However, little information is available concerning their derived SMs with antimicrobial effects. By extensive literature search and data analysis, as many as 185 antimicrobial natural products as SMs had been discovered from Fusarium strains by the end of 2022. This review first provides a comprehensive analysis of these substances in terms of various antimicrobial effects, including antibacterial, antifungal, antiviral, and antiparasitic. Future prospects for the efficient discovery of new bioactive SMs from Fusarium strains are also proposed.

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Section: Both Antibacterial and Antifungal Secondary Metabolitesmentioning

confidence: 99%

Fusarium-Derived Secondary Metabolites with Antimicrobial Effects

Huang

Zhu

et al. 2023

Molecules

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“…Et Mey were collected. [3][4][5][6][7][8][9][10][11][12][13] After collecting the data by LC-MS, the mass spectrum of each chromatographic peak was extracted. According to the quasimolecular ion and other information, the accurate relative molecular mass of the first-order mass spectrum was determined and compared with the literature, and the chromatographic peaks were preliminarily identified.…”

Section: Analysis Of the Active Componentsmentioning

confidence: 99%

The Activity, Composition and Molecular Mechanism of Bothriospermum zeylanicum (Hornem.) Fisch. Et Mey Alleviation of Nonsmall Cell Lung Cancer

Zhao,

Ge,

Liao

et al. 2024

Natural Product Communications

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Objective: To study the effect of the ethyl acetate extract of Bothriospermum zeylanicum (Hornem.) Fisch., the active ingredients and mechanism of Et Mey (EAF) in nonsmall cell lung cancer (NSCLC) were explored. Methods: 3-(4,5-dimethylthiazol-2-yl)-5-(3-carboxymethoxyphenyl)-2-(4-sulfophenyl)-2H-tetrazolium (MTS) assay was used to measure the effect of EAF on the proliferation of A549, HL-60, SMMC-7721, MDA-MB-231, and SW480 tumor cells. The components were analyzed by liquid chromatography-tandem mass spectrometry (LC-MS), and the blood components were retrieved from the constituents absorbed into the blood and metabolites of traditional Chinese medicine (DCABM-TCM) database. The mechanism was determined by network pharmacology and verified by molecular docking. Results: The IC50 values for the proliferation of tumor cell strains were 41.13, 56.72, 36.69, 48.63, and 44.48 μg/mL, respectively. A concentration of 100 μg/mL had the strongest inhibitory effect on A549 cells. A total of 33 chemical components were identified by LC-MS, 7 of which have been reported to have certain anti-NSCLC effects, and a total of 6 blood components were identified using the DCABM-TCM database. Network pharmacology analysis revealed that anti-NSCLC activity mainly involves EGFR tyrosine kinase inhibitor resistance, the PI3K-Akt signaling pathway, the AGE-RAGE signaling pathway in diabetic complications, the HIF-1 signaling pathway and the VEGF signaling pathway. The molecular docking results verified that hesperetin, luteolin, and pinocembrin bind well to the AKT1, IL6, EGFR, BCL2, and CASP3 target proteins. Conclusion: The ethyl acetate fraction of B. zeylanicum (Hornem.) Fisch. Et Mey had obvious ant-non NSCLC activity, which may be related to resistance to EGFR tyrosine kinase inhibitors and the PI3K-Akt signaling pathway in diabetic complications, and its active ingredients may be hesperetin, luteolin, and pinocembrin.

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“…Therefore, given the nature of their hosts, endophytic fungi could give beneficial effects on particular host plants, whereas they could be found as pathogens to other plants. [14] As repeatedly reported in the literature, fungal endophytes can provide many fitness benefits to their host as they are biologically active, [35] can enhance the growth of their hosts, and increase host resistance to disease-causing phytopathogens and environmental stress. Interestingly, many fungal endophytes can also produce bioactive metabolites as those found in the host plant.…”

Section: Endophytic Fungi Producing Huperzine a (Hup A) An Active Ach...mentioning

confidence: 99%

Production of Huperzine a by Fungal Endophytes Associated With Huperziaceae Plants

Ariantari¹,

Putri

2023

JPSA

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Background: Endophytic fungi are known as a producer of a myriad of bioactive natural products, including those originally produced by the host plants. Huperzine A (Hup A), a lycopodium alkaloid, which was reported as an active acetylcholinesterase inhibitor (AChEI) agent used for the treatment of Alzheimer’s disease, was originally isolated from medicinal Chinese herbs Huperzia serrata. Moreover, various species of endophytic fungi associated with H. serrata and other species within Huperziaceae plants were found capable of producing Hup A, suggesting these microorganisms as promising sources of Hup A. Objective: This review aimed to summarize the evidence of Hup A produced by various endophytic fungi as part of efforts to assess alternative producer of Hup A. Methods: Scientific articles on endophytic fungi producing Hup A published from 2000 until 2022 were screened through scientific databases. Results: Thirty-two endophytic fungal strains belonging to fifteen fungal genera were documented as capable of producing Hup A. These fungal endophytes were isolated from Huperziaceae plants, H. serrata, Phlegmariurus phlegmaria and Phlegmariurus taxifolius. Conclusion: We summarize herein the capability of endophytic fungal strains associated with Huperziaceae plants to produce Hup A, an active AChEI agent, which could be considered as an alternative producer of Hup A on a larger scale.Keywords: Acetylcholinesterase inhibitor (AChEI); Alzheimer’s disease; Fungal endophytes; Huperziaceae; Huperzine A (Hup A).

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Fusaristatins D–F and (7S,8R)-(−)-chlamydospordiol from Fusarium sp. BZCB-CA, an endophyte of Bothriospermum chinense

Cited by 6 publications

References 48 publications

Fusarium-Derived Secondary Metabolites with Antimicrobial Effects

Fusarium-Derived Secondary Metabolites with Antimicrobial Effects

The Activity, Composition and Molecular Mechanism of Bothriospermum zeylanicum (Hornem.) Fisch. Et Mey Alleviation of Nonsmall Cell Lung Cancer

Production of Huperzine a by Fungal Endophytes Associated With Huperziaceae Plants

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