Fusarial Toxins and their Role in Animal Diseases

Čonková, E.; Laciakova, A.; Kováč, G.; Seidel, H.

doi:10.1016/s1090-0233(02)00127-2

Cited by 95 publications

(39 citation statements)

References 46 publications

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“…FB 1 was found to be the cause of a number of outbreaks of equine leukoencephalomalacia (Conkova et al, 2003) and porcine pulmonary oedema killing many horses and pigs in the U.S. during 1989and 1990(Marasas, 2001. These lesions appeared to be a consequence of impairment of vascular permeability provoked by disruption of sphingolipid metabolism by FB 1 (Ramasamy et al, 1995).…”

Section: Introductionmentioning

confidence: 99%

Feed exposure to FB1 can aggravate pneumonic damages in pigs provoked by P. multocid a

Kovács

Pósa

Tuboly

et al. 2016

Research in Veterinary Science

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The possible interaction between Pasteurella multocida and the mycotoxin fumonisin B1 (FB1), recognised as one of the most often food/feed contaminant, was studied with the aim to evaluate whether and how FB1 can influence and/or complicate the development and severity of various pathological damages provoked by Pasteurella multocida in some internal organs of pigs. Heavier lung pathology was seen in pigs experimentally infected with Pasteurella multocida, when the same were exposed to 20 ppm dietary levels of fumonisin B 1 (FB 1 ) as was assessed by gross pathology, pathomorphological examinations, clinical biochemistry and some immunological investigations. The most typical damages in FB 1 treated pigs were the strong oedema in the lung and the slight oedema in the other internal organs and mild degenerative changes in the kidneys, whereas the typical pathomorphological findings in pigs infected with Pasteurella multocida was broncho-interstitial pneumonia. FB1 was found to aggravate pneumonic changes provoked by P. multocida in the cranial lobes of the lung and to complicate pneumonic damages with interstitial oedema in the lung. No macroscopic damages were observed in the pigs infected only with Pasteurella multocida. It can be concluded that the feed intake of FB1 in pigs may complicate or exacerbate the course of P. multocida serotype A infection.

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Section: Introductionmentioning

confidence: 99%

Feed exposure to FB1 can aggravate pneumonic damages in pigs provoked by P. multocid a

Kovács

Pósa

Tuboly

et al. 2016

Research in Veterinary Science

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“…Fusariotoxins are secondary metabolites produced by toxigenic micromycetes of the genus Fusarium (F) (Conkova et al, 2003). Fusarium species might endanger human health through the action of their toxic metabolites, mycotoxins (Bauer et al, 1980).…”

Section: Introductionmentioning

confidence: 99%

Human exposure to mycotoxins and their masked forms through cereal-based foods in Belgium

et al. 2013

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In the present study, a quantitative dietary exposure assessment of mycotoxins and their masked forms was conducted on a national representative sample of the Belgian population using the contamination data of cereal-based foods. Cereal-based food products (n = 174) were analysed for the occurrence of deoxynivalenol, 3-acetyldeoxynivalenol, 15-acetyldeoxynivalenol, zearalenone, α-zearalenol, β-zearalenol, T-2-toxin, HT-2-toxin, and their respective masked forms, including, deoxynivalenol-3-glucoside, zearalenone-4-glucoside, α-zearalenol-4-glucoside, β-zearalenol-4-glucoside and zearalenone-4-sulfate.Fiber-enriched bread, bran-enriched bread, breakfast cereals, popcorn and oatmeal were collected in Belgian supermarkets according to a structured sampling plan and analysed during the period from April 2010 till October 2011. The habitual intake of these food groups was estimated from a national representative food intake survey. According to a probabilistic exposure analysis, the mean (and P95) mycotoxin intake for the sum of the deoxynivalenolequivalents, zearalenone-equivalents, and the sum of HT-2-and T-2-toxin for all cereal-based foods was 0.1162 (0.4047, P95), 0.0447 (0.1568, P95) and 0.0258 (0.0924, P95) µg kg -1 body weight day -1 , respectively. These values were below the tolerable daily intake (TDI) levels for deoxynivalenol, zearalenone and the sum of T-2 and HT-2 toxin (1.0, 0.25 and 0.1 µg kg -1 body weight day -1 , respectively). The absolute level exceeding the TDI for all cereal-based foods was calculated, and recorded 0.85%, 2.75% and 4,11% of the Belgian population, respectively. KEYWORDS: mycotoxins,

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“…Metabolites such as lytic enzymes and toxic substances, known as mycotoxins, are prominent among the virulence factors of members of this genus (6,(10)(11)(12). Fusarium also produces phytotoxins, antibiotics and pigments (13).…”

Section: Introductionmentioning

confidence: 99%

Toxic thermoresistant metabolites of Fusarium oxysporum are capable of inducing histopathological alterations in Wistar rats

Hernandes¹,

Marangon²,

Salci³

et al. 2012

J. Venom. Anim. Toxins incl. Trop. Dis

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Abstract:The genus Fusarium is known to produce mycotoxins that cause fusariosis in plants, animals and humans. Mycotoxins are among the virulence factors of this genus. Metabolic extracts of Fusarium oxysporum, isolated from a patient with onychomycosis and sterilized by filtration or autoclave, were inoculated intradermally into Wistar rats at concentrations of 0.25, 0.5 and 1 μg/μL, and the effects on their tegument were observed at 24 and 72 hours. After histological procedures and staining by hematoxylineosin, the sections were studied for their inflammatory-reaction intensity and for evidence of injury and tissue distortion. Inflammatory reactions in the dermis and the subcutaneous tissue were observed at all concentrations of the inoculated extract tested. There was a significant influx of neutrophils, mastocytes and lymphocytes, as well as a large quantity of macrophages. Apoptotic bodies and hyperemic blood vessels were observed. This reaction was directly related to the extract concentration, and was most intense in animals that received the 1 mg/µL dose. The maximum peak was observed at 24 hours. The autoclaved metabolic extract produced the same effects as the untreated one, indicating the presence of heat-resistant metabolites. In conclusion, the metabolic extracts obtained from sterilized culture filtrates of F. oxysporum are capable of inducing an inflammatory response within 24 hours in the dermis and subcutaneous tissue of rats.

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Fusarial Toxins and their Role in Animal Diseases

Cited by 95 publications

References 46 publications

Feed exposure to FB1 can aggravate pneumonic damages in pigs provoked by P. multocid a

Feed exposure to FB1 can aggravate pneumonic damages in pigs provoked by P. multocid a

Human exposure to mycotoxins and their masked forms through cereal-based foods in Belgium

Toxic thermoresistant metabolites of Fusarium oxysporum are capable of inducing histopathological alterations in Wistar rats

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