Furunculosis in the Goldfish <i>Carassius auratus</i> (L.)

Mawdesley-Thomas, Lionel E.

doi:10.1111/j.1095-8649.1969.tb03840.x

Cited by 39 publications

(23 citation statements)

References 12 publications

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“…As one of the most important diseases of freshwater fishes, there is an extensive literature on the pathogenesis of red-sore disease (Amlacher 1970;Gaines 1972;Mawdesley-Thomas 1969;Schaperclaus 1965;Wolke 1975). However, the histopathology of red-sore disease has been most completely studied in carp Cyprinus carpio L. (Amlacher 1970) and channel catfish Ictalurus punctatus (Rafinesque) (Gaines 1972).…”

Section: Discussionmentioning

confidence: 99%

“…However, the histopathology of red-sore disease has been most completely studied in carp Cyprinus carpio L. (Amlacher 1970) and channel catfish Ictalurus punctatus (Rafinesque) (Gaines 1972). The pathogenesis of furunculosis, a closely related disease caused by Aeromonas salmonicida, has been described in brown trout Salmo trutta L. (Ferguson & McCarthy 1978) and goldfish Carassius auratus (L.) (Mawdesley-Thomas 1969).…”

Section: Discussionmentioning

confidence: 99%

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Histopathology of red‐sore disease (Aeromonas hydrophila) in naturally and experimentally infected largemouth bass Micropterus salmoides (Lacepede)

Huizinga

Esch

Hazen

1979

Journal of Fish Diseases

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The histopathology of red-sore disease, caused by the gram-negative bacterium, Aeromonas hydrophila, is described for largemouth bass, Micropterus salmoides. Externally, lesions range from those affecting a few scales (pin-point), to those associated with extensive chronic ulcerations; there is focal haemorrhage, oedema and dermal necrosis which exposes underlying muscles producing infiltration of mononuclear and granulocytic inflammatory cells. Internally, the liver and kidneys are foci for toxic products produced by A. hydrophila with, in the most severe cases, complete destruction of the structural integrity of both organs. Pathological changes were not serious in either the spleen or heart, even in cases with massive damage in the liver and kidney. Internal and external lesions were similar in both natural and experimentally induced infections. The pathobiology of red-sore disease in bass is postulated to be linked to elevated water temperature stimulating increased metabolism, decreased body condition and stress, leading to the increased production of corticosteroids and the concomitant rise in susceptibility to infection.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Histopathology of red‐sore disease (Aeromonas hydrophila) in naturally and experimentally infected largemouth bass Micropterus salmoides (Lacepede)

Huizinga

Esch

Hazen

1979

Journal of Fish Diseases

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“…The virulence factor(s) of Aeromonas salmonicida, the causative agent of furunculosis, has been the subject of considerable interest in salmonids and other fish species. The pathogenesis of furunculosis is not clearly understood because of a lack of knowledge of the factor responsible for the pathogenic and lethal effects of this disease (Klontz, Yasutake & Ross 1966;Mawdesley-Thomas 1969;Ferguson & McCarthy 1978). Wedemeyer, Ross & Smith (1969), Anderson (1973) and Paterson & Fryer (1974) reported that A. salmonicida endotoxin (lipopolysaccharide) failed to provoke pathological effects in salmon.…”

Section: Introductionmentioning

confidence: 99%

The non‐specific activation of rainbow trout, Salmo gairdneri Richardson, complement by Aeromonas salmonicida extracellular products and the correlation of complement activity with the inactivation of lethal toxicity products

Sakai¹

1984

Journal of Fish Diseases

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The possible mechanism of inactivation of the toxieity of Aeromonas salmonicida extracellular products (ECP) by normal rainbow trout serum was investigated using juvenile rainbow trout. ECP was prepared from culture supernatant by an acetone precipitation method. The ECP was incubated with normal rainbow trout serum at 20°C for 2 h, and the interrelationship between ECP proteolytic activity and immune complex-initiating, haemolytic complement activity (CH50) of normal serum against antibody-sensitized goldfish red blood cells was evaluated. When normal serum was incubated with increasing concentrations of ECP, the CH50 activity of serum decreased. The CH50 activity was completely abolished in serum treated with undiluted ECP. ECP treated with serum was administered to trout intraperitoneally to determine mortality. All the fish receiving untreated ECP (0-05 ml = 0-5 mg protein) alone died within 24 h. When ECP was treated with serum at 1:1 to 4:1 (serum: ECP) in volume a similar high mortality was produced. These inocula possessed high protease activity and no or low CH50 activity. However, mortality decreased and finally no mortality was recorded as ECP was treated with large volumes of serum (9:1 to 19:1). These inocula had lower protease activity and considerably higher CHso activity. Fish receiving ECP treated with heat-inactivated serum at 19:1 showed 100% mortality. A serum: ECP inoculum derived from fish which had been administered lipopolysacchadde from Salmonella enteritidis and which possessed a low CHoo activity also gave a high mortality when used at 19:1. These results suggest that rainbow trout complement is implicated in the inactivation of toxieity of A. salmonicida ECP.

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“…By 72 h there were no longer any leukocytes in the expanding lesion. Tn describing an outbreak of furunculosis in goldfish, Mawdesley-Thomas (1969) used the term ' chronic cellular infiltration '. The illustration of this point shows a dense cellular infiltration at the margin of the necrotic lesion, extending into the adjacent musculature.…”

Section: Introductionmentioning

confidence: 99%

The inflammatory response of rainbow trout*

Finn

Nielson²

1971

Journal of Fish Biology

120

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The basic responses of piscine tissues to inflammatory agents were investigated, using light microscopy. Tissue sections, smears and blood smears were examined. The period studied was from 3 h to 16 days after initial injury at 15" C . The piscine inflammatory response was compared to that of mammals, especially that of mice. The responses examined were basically similar to those of msmmals. They varied by being less intense and slower to appear and resolve.

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Furunculosis in the Goldfish Carassius auratus (L.)

Cited by 39 publications

References 12 publications

Histopathology of red‐sore disease (Aeromonas hydrophila) in naturally and experimentally infected largemouth bass Micropterus salmoides (Lacepede)

Histopathology of red‐sore disease (Aeromonas hydrophila) in naturally and experimentally infected largemouth bass Micropterus salmoides (Lacepede)

The non‐specific activation of rainbow trout, Salmo gairdneri Richardson, complement by Aeromonas salmonicida extracellular products and the correlation of complement activity with the inactivation of lethal toxicity products

The inflammatory response of rainbow trout*

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