Further studies on quantification of drug-induced tremor in mice: Effects of antitremorgenic agents on tremor frequency

Shinozaki, H.; Hirate, Kenji; Ishida, Michiko

doi:10.1016/0014-4886(85)90193-1

Cited by 16 publications

(16 citation statements)

References 28 publications

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“…Dantrolene and atropine suppressed the power spectral density without affecting tremor frequency. These experimental results suggested a positive relationship between the change of tremor frequency and the site of action of anti-tremorgenic agents (9).…”

Section: Conventionalmentioning

confidence: 72%

“…In our previous studies (7)(8)(9), a quantitative method of analyzing drug-induced tremor in mice was developed using a power spectral analysis of the random current induced by the move ment of a magnet attached to a mouse on a wire coil. The power spectra of the drug induced tremor consisted of some different tremor components and a single component of the spontaneous motor activity, irrespective of the magnitude of the power density.…”

Section: Conventionalmentioning

confidence: 99%

“…The third component was absent in the harmaline-induced tremor. Using this power spectral method, the effect of some anti-tremorgenic agents has been analyzed with special reference to the tremor frequency (9). Diazepam markedly depressed the power spectral density of the tremorine and harmaline-induced tremor and reduced the tremor frequency.…”

Section: Conventionalmentioning

confidence: 99%

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Depression of Drug-Induced Tremor by a New Isoxazol Derivative in Mice

Shinozaki

Hirate

1986

Japanese Journal of Pharmacology

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Abstract-The effects of a newly synthesized compound, MLV-208, on drug induced tremor were investigated in mice. The study involved a power spectral analysis of the random current induced by movement of a magnet attached to the mouse on a wire coil. To induce tremor, tremorine and harmaline were subcu taneously injected.The power spectral density function defined the frequency composition of the tremor, and its severity was determined quantitatively in terms of the mean square value of the data in any frequency range of concern.MLV-208 depressed the power spectral density of both the tremorine and harmaline-induced tremors, but reduced more effectively the former than the latter. The peak frequency of the tremorine-induced tremor did not change in the presence of MLV-208, while MLV-208 sometimes developed a new peak of the power spectral densities of the harmaline-induced tremor in the low frequency side, in addition to the original tremor component.

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Section: Conventionalmentioning

confidence: 72%

Section: Conventionalmentioning

confidence: 99%

Section: Conventionalmentioning

confidence: 99%

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Depression of Drug-Induced Tremor by a New Isoxazol Derivative in Mice

Shinozaki

Hirate

1986

Japanese Journal of Pharmacology

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“…The methods were essentially similar to those described previously (Shinozaki, 1984;Shinozaki et al, 1985). Male albino mice (ICR strain, 9 weeks old) had food and water ad libitum before the experiments.…”

Section: Antagonism Of Drug-induced Tremor In Micementioning

confidence: 99%

“…quantitatively the severity of the tremor in the experimental animal by using the power spectral method (Shinozaki, 1984;Shinozaki et al, 1985), the severity ofdrug-induced tremor was quantitatively determined (see Methods). The power spectral data fitted the theoretical curve well regardless of the presence or absence of MLV-6976, although the magnitude of the power spectral density varied in each animal.…”

Section: Antagonism Of Drug-induced Tremor In Micementioning

confidence: 99%

A new class of potent centrally acting muscle relaxants: pharmacology of oxazolidinones in rat decerebrate rigidity

Masaki

Shinozaki

1986

British J Pharmacology

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1 The severity of anaemic decerebrate rigidity was quantitatively determined by measuring the frequency of electromyographic potentials in the rat. 2 Some oxazolidinones markedly reduced the severity ofthis decerebrate rigidity in a dose-dependent manner,one (MLV-6976) being the most potent. In addition to the oxazolidinones, an aminoalcohol derivative, (1RS,2SR)-5-methyl-1-phenyl-2-(3-piperidinopropylamino)hexan-1-ol (MLV-5860) also reduced the rat decerebrate rigidity. 3 In the oxazolidinone series, the optical isomers with absolute configuration (S) at the 4-position were more potent than the corresponding (4R)-isomers, while there was no significant difference in their LD50 values. 4 Normal rats and mice receiving MLV-6976 at doses which reduced decerebrate rigidity showed no behavioural changes, impairment of motor coordination only appearing at extremely high doses. MLV-6976 and its derivatives did not affect spinal reflex potentials in cats. 5 MLV-6976 reduced the severity of harmaline-induced tremor in mice in a dose-dependent manner, but slightly augmented tremorine-induced tremor. 6 The frequency of the spike discharges induced by iontophoretically applied glutamate was reduced by MLV-6976 in a dose-dependent manner in rat cortical neurones. 7 The amplitude of miniature endplate potentials of the rat diaphragm was decreased by MLV-6976 only at concentrations greater than 0.1 mM. 8 It is concluded that MLV-6976 acts on the brainstem or/and higher levels of the brain rather than on the spinal cord or the peripheral nervous system to reduce the excessive activities of the nervous system.

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