Depression of Drug-Induced Tremor by a New Isoxazol Derivative in Mice

Abstract

Abstract-The effects of a newly synthesized compound, MLV-208, on drug induced tremor were investigated in mice. The study involved a power spectral analysis of the random current induced by movement of a magnet attached to the mouse on a wire coil. To induce tremor, tremorine and harmaline were subcu taneously injected.The power spectral density function defined the frequency composition of the tremor, and its severity was determined quantitatively in terms of the mean square value of the data in any frequency range of concern.MLV-208 depressed the power spectral density of both the tremorine and harmaline-induced tremors, but reduced more effectively the former than the latter. The peak frequency of the tremorine-induced tremor did not change in the presence of MLV-208, while MLV-208 sometimes developed a new peak of the power spectral densities of the harmaline-induced tremor in the low frequency side, in addition to the original tremor component.

A new class of potent centrally acting muscle relaxants: pharmacology of oxazolidinones in rat decerebrate rigidity

“…The results were quite similar to those described previously Shinozaki & Hirate, 1986). Gross observations of the test groups receiving MLV-6976, revealed that neither the tremor nor the other effects induced by tremorine seemed to be reduced.…”

“…Mice receiving tremorine at a subcutaneous dose of 70 mg kg' demonstrated severe tremor, diminished normal locomotor activity, and profuse salivation, lachrymation and diarrhoea. The results were quite similar to those described previously Shinozaki & Hirate, 1986). Gross observations of the test groups receiving MLV-6976, revealed that neither the tremor nor the other effects induced by tremorine seemed to be reduced.…”

“…Using this animal model to search for new central muscle relaxants, ]amino-3-phenylisoxazole) has been shown to have an inhibitory action on decerebrate rigidity in rats, as well as on drug-induced tremor in mice (Shinozaki & Hirate, 1986). Furthermore, MLV-208 demonstrated a powerful inhibitory action on the glutamate-induced response at the crayfish neuromuscular junction (Shinozaki & Ishida, unpublished observations).…”

“…Animals with decerebrate rigidity have proved useful for the study of the mechanisms of action of the centrally acting muscle relaxants and some CNS depressants (Maxwell & Read, 1972;Sontag & Wand, 1973;Maxwell & Sumpter, 1974;Fukuda et al, 1974a,b;Anderson & Raines, 1976;Wand et al, 1977;Ochiai & Ishida, 1982;Goto et al, 1982;1983;Raines et al, 1985). Using this animal model to search for new central muscle relaxants, ]amino-3-phenylisoxazole) has been shown to have an inhibitory action on decerebrate rigidity in rats, as well as on drug-induced tremor in mice (Shinozaki & Hirate, 1986). Furthermore, MLV-208 demonstrated a powerful inhibitory action on the glutamate-induced response at the crayfish neuromuscular junction (Shinozaki & Ishida, unpublished observations).…”

Effective Synthesis and Anti‐Mycobacterial Activity of Isoxazole‐Substituted Piperazine Derivatives

“…Besides, isoxazole, as a very important five‐membered heterocyclic compound containing nitrogen and oxygen, is widely used in organic synthesis and medical fields because of its good biological activity and pharmacological activity. Previous works have demonstrated that the compounds bearing isoxazole group had a series of pharmacological and biological activities such as anti‐HIV, [20] anti‐tumor, [21,22] antioxidant, [23] antimicrobial, [24] anti‐TB, [25,26] anti‐depression, [27,28] anti‐fungal, [29,30] DNA elimination, [31–33] anti‐cancer, [34,35] and so on. Besides, lots of its derivatives can be used in pesticide field with high efficiency, unique mechanism and non‐pollution [36] .…”