Further Studies on Experimental Endometriosis*

Scott, Roger B.; Linde, R.; Wharton, Lawrence R.

doi:10.1016/s0002-9378(16)38618-5

Cited by 70 publications

(14 citation statements)

References 16 publications

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“…The viability of endometrial cells was demonstrated by culture of the menstrual effluent or peritoneal fluid [5,6]. Experimental studies also proved that endometriosis could be induced by exposure of the pelvis to increased amounts of menstrual discharge [7,8]. Implantation of endometrial tissue also experimentally induced endometriosis in rabbits [9,10].…”

Section: Presence Attachment Invasionmentioning

confidence: 99%

Current Thinking on the Pathogenesis of Endometriosis

Donnez

Langendonckt

Casanas-Roux

et al. 2002

Gynecol Obstet Invest

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This manuscript is a review of new ideas regarding the pathogenesis of peritoneal endometriosis, ovarian endometriosis, and retroperitoneal adenomyosis. Peritoneal endometriosis, the different aspects of which (black, red and white) represent distinctive steps in the evolutionary process, can be explained by the transplantation theory. Red lesions are the most active and most highly vascularized lesions and are considered to be the first stage of peritoneal endometriosis. The retroperitoneal nodule is an adenomyotic nodule whose histopathogenesis is not related to the implantation of regurgitated endometrial cells but to metaplasia of Müllerian remnants located in the rectovaginal septum. Metaplastic changes of Müllerian rests into adenomyotic glands involving the rectovaginal septum and the retroperitoneal space are responsible for the striking proliferation of the smooth muscle, creating an adenomyomatous appearance similar to that of adenomyosis in the endometrium.

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Section: Presence Attachment Invasionmentioning

confidence: 99%

Current Thinking on the Pathogenesis of Endometriosis

Donnez

Langendonckt

Casanas-Roux

et al. 2002

Gynecol Obstet Invest

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“…Experi mental studies in monkeys [9,10] and in humans [11] confirm this theory principally based on retrograde menstruation. Certainly, in the presence of mechanical factors or ob structive genital anomalies (case 2) endome triosis may develop, but as case 4 and others with similar syndromes show, this does not always occur.…”

Section: Discussionmentioning

confidence: 73%

Endometriosis and Genital Anomalies:Some Histogenetic Aspects of External Endometriosis

Acién¹

1986

Gynecol Obstet Invest

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Six cases with a coexistence of endometriosis and genital anomalies among 112 patients with external endometriosis and 90 patients with genital anomaly were detected. Three cases of severe endometriosis associated with uterovaginal duplication, unilateral renal agenesis and ipsilateral blind vagina and the latter in a patient with Rokitansky-Kuster-Hauser syndrome are presented. Another case with obstructive genital anomaly without endometriosis is also presented. The histogenetic mechanisms of endometriosis are discussed. The transplantation theory is not sufficient to explain all the cases and, therefore, the theory of celomic metaplasia and the theory of müllerian remains or Cullen’s theory, as well as the intervention of genetic-constitutional, immunologic, hormonal and other factors must also be considered.

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“…One monkey died of tuberculosis, but one to four endometrial grafts were viable in each of the other six monkeys after 26 to 522 days (Te Linde and Scott 1950). Scott et al (1953) reported another non-human primate model. In a rhesus monkey, the descending uterine vessels were clamped, cut, and tied, the distal cervix was transected and the proximal cervix was moved to the anterior abdominal wall.…”

Section: Non-human Primate Models Of Endometriosismentioning

confidence: 99%

“…The peritoneum was then stripped over an area 15 mm wide from the proximal cervix and the abdominal peritoneum was attached to the remaining intact peritoneum around the uterus. The cervix was placed into a pocket in the rectus abdominis muscle for one year, after which viable endometrial stroma and glands, smooth and striated muscle, and a fibrous tissue reaction were found in this area (Scott et al 1953). Various other studies of endometriosis have since been performed in monkeys.…”

Section: Non-human Primate Models Of Endometriosismentioning

confidence: 99%

Primate Model Research for Endometriosis

Yamanaka

Kimura

Takebayashi

et al. 2012

Tohoku J. Exp. Med.

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Non-Human Primate Models of Endometriosis 95 Tohoku J. Exp. Med., 2012, 226, 95-99 95 Received November 29, 2011; revision accepted for publication January 6, 2012January 6, . doi: 10.1620 Endometriosis is defined as the existence of endometrial tissue outside the uterine cavity, and it includes a chronic, inflammatory reaction associated with female infertility and pelvic pain. Endometriosis occurs in 7 to 10% of women. Although it has been studied for more than 50 years, the pathogenesis and development of endometriosis are still poorly understood. There is no curative therapy for endometriosis, which often recurs after surgical or medical treatment. There is a consensus that the adverse current of menstrual blood plays a crucial role in the development of endometriosis. This places a major limitation on research using rodent models of endometriosis, although these are still widely employed, because rodents do not menstruate and endometriosis does not occur spontaneously in these animals. In fact, menstruation and spontaneous endometriosis only occur in women and some non-human primates, making models that employ non-human primates the best animal models for research into the pathogenesis, pathophysiology, spontaneous onset, and treatment of endometriosis. This review assesses the effectiveness and potential of the non-human primate models of endometriosis. It also describes the current findings and theories on the pathogenesis of endometriosis that have been obtained by research using non-human primates.

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Further Studies on Experimental Endometriosis*

Cited by 70 publications

References 16 publications

Current Thinking on the Pathogenesis of Endometriosis

Current Thinking on the Pathogenesis of Endometriosis

Endometriosis and Genital Anomalies:Some Histogenetic Aspects of External Endometriosis

Primate Model Research for Endometriosis

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