Further Observations on an Inhibitor Principle Associated with the Causative Agent of a Chicken Tumor

In a preceding paper (1) the clinical and pathological characteristics of a tumor-like condition of rabbits were described. The purpose of the present paper is to report experiments indicating the nature of the etiological agent and to point out its possible relationship to the virus of infectious myxoma. As in the preceding paper, the term "tumor" is used in its broadest sense, to indicate a local swelling consisting of a mass of new tissue.

Section: Discussionmentioning

confidence: 99%

A Filtrable Virus Causing a Tumor-Like Condition in Rabbits and Its Relationship to Virus Myxomatosum

Shope

1932

“…These tests permit the conclusion that the agent readily passes 1.5 per cent collodion membranes and suggest the presence of inhibitory substances in leucemic plasma (cf. 20,21). Only one of the six fowls injected with plasma passed through 3 per cent membranes, developed leucosis.…”

Section: Passage XVIImentioning

confidence: 99%

Studies on the Nature of the Agent Transmitting Leucosis of Fowls

Fürth

Miller

1932

The agent transmitting leucosis readily passed all types of silicious filters. Filtration is particularly successful when the plasma is freed from particles and substances that would otherwise obstruct the pores of the filter. Filtration through fine filters seems to be facilitated by preceding filtration through coarse filters. A comparison of the periods of incubation of leucosis produced by unfiltered plasma and plasma passed through silicious filters shows that as a result of filtration, the incubation periods are somewhat prolonged. This suggests a slight or moderate decrease in the concentration of the transmitting agent in the plasma caused by filtration. Filtration tests through collodion membranes indicate that the agent transmitting leucosis is much smaller than the virus of bovine pleuropneumonia (250 mµ) and that it approximates the size of bacteriophage.

“…Chicken Tumor X, a very slow-growing fibrosarcoma, has proved a source of an inhibitor for Chicken Tumor I and Mouse Tumor 180 (3,4). The inhibitor, judged by previous tests, is less potent than that from Chicken Tumor I, which might be due to the fact that the agent with which it is associated is less vigorous.…”

Section: Release Of Inhibitor From Chicken Tumor X After Adsorption Omentioning

confidence: 99%

Properties of the Causative Agent of a Chicken Tumor

Murphy

Sturm

1932

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