Further isoflavonoid metabolites from Millettia griffoniana (Bail)

Isolation and structure elucidation of bioactive compounds from the roots of the Tunisian Ononis angustissima L.

“…In addition, the neuroprotective activity of six isolated molecules (4-7, 9, 10) were evaluated. Following the exposure of PC12 cells to Ab [25][26][27][28][29][30][31][32][33][34][35] , compounds 9 and 10 triggered a significant increase of cell viability and in a dose dependant manner.…”

“…33,34 The 1 H NMR spectrum of 1 revealed signals for five aromatic protons. One ortho-coupled doublet at d H 8.07 (J = 8.4 Hz), one meta-coupled doublet at d H 6.89 (J = 2.2 Hz) and one ortho, meta-coupled split doublet at d H 6.96 (J = 8.4, 2.2 Hz) attributed to H 5 , H 8 and H 6 , respectively, and two singlets at d H 6.77 and d H 7.04 assigned to H 3 0 and H 6 0 , respectively.…”

“…We performed in consequence the neuroprotective assays for each compounds with the appropriate concentration(s), the one(s) that did not affect cell viability. Firstable, we noted that Ab [25][26][27][28][29][30][31][32][33][34][35] induced approximately 60% of cell death (Fig. 3).…”

Gc-MS Analysis of Phytochemical Constituents in the Petroleum Ether Leaf Extracts of Millettia Peguensis

“…The flavonoids chalcones isolated from M. ovalifolia showed antimalarial activitiy 10 and Isoflavonoids; griffonianone and maximaisoflavone isolated from M. griffoniana showed significant cytotoxicity 9 . M. dura contains 6α, 12α-didehydro-6-oxodeguelin has good insecticidal activity and played a key role as a phytotoxin inhibitor of ornithine decarboxylase 11 . M. griffoniana contains griffonianone C which showed a potent estrogenic activity 9 and Millepurone has antitumour promoted reported from M. atropurpurea.…”

New Isoflavone Glycoside from the Woods of Sophora japonica

“…6 The structure of compound 1 was identified by using C NMR spectra (Table 1), respectively, were suggestive of an isoflavone type skeleton. 7 The HMBC correlations of proton signal at δ 8.10 ppm (H-2) to the carbon signals at δ 121.2 ppm (C-3), δ 182.3 ppm (C-4), δ 159.8 ppm (C-9), δ 114.9 ppm (C-1') showed that compound 1 is an isoflavone derivative (Fig. 1).…”