Further definition of the effect of corticosterone on the sleep–wake pattern in the male rat

Vázquez-Palacios, Gonzalo; Retana‐Márquez, Socorro; Bonilla-Jaime, Herlinda; Velázquez‐Moctezuma, Javier

doi:10.1016/s0091-3057(01)00620-7

Cited by 60 publications

(29 citation statements)

References 29 publications

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“…On the one hand, adrenalectomy, i.e., removal of the adrenal gland and hence of the CORT source, results in shorter sleep episodes, less NREMS and more waking during the resting phase in the rat, with an opposite pattern during the active phase. Replacement with basal levels of CORT (approximately 5 μg/dl), restores normal sleep pattern, whereas higher doses (resulting in twice as much plasma levels) inhibits NREMS (Bradbury et al, 1998) and increases waking time (Vazquez-Palacios et al, 2001). Addison’s Disease patients (who are characterized by adrenal insufficiency) also display impairment of sleep continuity, increased REMS latency and reduced percentage of REMS, problems that can be normalized by hydrocortisone replacement at bed time (Garcia-Borreguero et al, 2000).…”

Section: Effects Of Stress Hormones On Sleepmentioning

confidence: 99%

REM Sleep Rebound as an Adaptive Response to Stressful Situations

Suchecki¹,

Tiba²,

Machado³

2012

Front. Neur.

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Stress and sleep are related to each other in a bidirectional way. If on one hand poor or inadequate sleep exacerbates emotional, behavioral, and stress-related responses, on the other hand acute stress induces sleep rebound, most likely as a way to cope with the adverse stimuli. Chronic, as opposed to acute, stress impairs sleep and has been claimed to be one of the triggering factors of emotional-related sleep disorders, such as insomnia, depressive- and anxiety-disorders. These outcomes are dependent on individual psychobiological characteristics, conferring even more complexity to the stress-sleep relationship. Its neurobiology has only recently begun to be explored, through animal models, which are also valuable for the development of potential therapeutic agents and preventive actions. This review seeks to present data on the effects of stress on sleep and the different approaches used to study this relationship as well as possible neurobiological underpinnings and mechanisms involved. The results of numerous studies in humans and animals indicate that increased sleep, especially the rapid eye movement phase, following a stressful situation is an important adaptive behavior for recovery. However, this endogenous advantage appears to be impaired in human beings and rodent strains that exhibit high levels of anxiety and anxiety-like behavior.

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Section: Effects Of Stress Hormones On Sleepmentioning

confidence: 99%

REM Sleep Rebound as an Adaptive Response to Stressful Situations

Suchecki¹,

Tiba²,

Machado³

2012

Front. Neur.

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“…Many neurotransmitters regulate sleep patterns, including neurotransmitters and hormones activated by stress such as dopamine (2), acetylcholine (12), and corticosterone (2,13). The γ-aminobutyric acid (GABA) B receptor is widely distributed and plays an important role in regulating central nervous system function (14).…”

Section: Introductionmentioning

confidence: 99%

The Effect of Baclofen on Alterations in the Sleep Patterns Induced by Different Stressors in Rats

Cui

Suemaru

et al. 2009

J Pharmacol Sci

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Abstract. We have previously reported that sleep patterns are significantly affected by both physical and psychological stress induced by a communication box ; however, the mechanism by which stress alters sleep patterns was not established. In the present study, we investigated the role of γ-aminobutyric acid (GABA), acting through the GABA B receptor, on stress-induced changes in sleep patterns. Our results show that physical stress increased the total wakefulness time by increasing sleep latency and inhibiting both rapid eye movement (REM) and non rapid eye movement (NREM) sleep during a 6 h sleep-recording period. The GABA B agonist baclofen (20 pmol /2 μl) attenuated the effects of physical stress on sleep latency, total wakefulness, and NREM sleep, but not total REM sleep. In contrast, psychological stress enhanced total REM sleep and shortened REM sleep latency without altering other sleep patterns. The effect of psychological stress on total REM sleep was also reversed by baclofen. These results suggest that GABA via GABA B receptors may play a role in the regulation of specific sleep patterns by both physical and psychological stress.

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“…These findings strongly suggest that optimal GC concentrations are essential for normal sleep patterns in humans (41, 42). In rats, a similar phenomenon is also observed, with high levels of corticosterone being especially detrimental to NREMS (43). …”

Section: Hormonal Regulation Of Stress-induced Sleep Reboundmentioning

confidence: 69%

Neuroendocrine and Peptidergic Regulation of Stress-Induced REM Sleep Rebound

Machado

Suchecki

2016

Front. Endocrinol.

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Sleep homeostasis depends on the length and quality (occurrence of stressful events, for instance) of the preceding waking time. Forced wakefulness (sleep deprivation or sleep restriction) is one of the main tools used for the understanding of mechanisms that play a role in homeostatic processes involved in sleep regulation and their interrelations. Interestingly, forced wakefulness for periods longer than 24 h activates stress response systems, whereas stressful events impact on sleep pattern. Hypothalamic peptides (corticotropin-releasing hormone, prolactin, and the CLIP/ACTH18–39) play an important role in the expression of stress-induced sleep effects, essentially by modulating rapid eye movement sleep, which has been claimed to affect the organism resilience to the deleterious effects of stress. Some of the mechanisms involved in the generation and regulation of sleep and the main peptides/hypothalamic hormones involved in these responses will be discussed in this review.

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Further definition of the effect of corticosterone on the sleep–wake pattern in the male rat

Cited by 60 publications

References 29 publications

REM Sleep Rebound as an Adaptive Response to Stressful Situations

REM Sleep Rebound as an Adaptive Response to Stressful Situations

The Effect of Baclofen on Alterations in the Sleep Patterns Induced by Different Stressors in Rats

Neuroendocrine and Peptidergic Regulation of Stress-Induced REM Sleep Rebound

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