The Effect of Baclofen on Alterations in the Sleep Patterns Induced by Different Stressors in Rats

Cui, Ranji; Li, Bingjin; Suemaru, Katsuya; Araki, Hiroaki

doi:10.1254/jphs.08068fp

Cited by 7 publications

(4 citation statements)

References 48 publications

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“…Some studies reported that baclofen treatment was associated with sleep disturbance among AUD patients (44, 63). These findings are supported by preclinical evidence showing that baclofen may alter normal sleep patterns in animal models (126, 127). As AUD patients often suffer from disturbed sleep [particularly during AWS; APA (3)], it is possible that baclofen treatment may increase the risk and/or severity of sleep disorders among AUD patients.…”

Section: Baclofen (Off-label) Use For the Treatment Of Moderate To Sesupporting

confidence: 59%

The Use of Baclofen as a Treatment for Alcohol Use Disorder: A Clinical Practice Perspective

et al. 2019

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Alcohol use disorder (AUD) is a brain disorder associated with high rates of mortality and morbidity worldwide. Baclofen, a selective gamma-aminobutyric acid-B (GABA-B) receptor agonist, has emerged as a promising drug for AUD. The use of this drug remains controversial, in part due to uncertainty regarding dosing and efficacy, alongside concerns about safety. To date there have been 15 randomized controlled trials (RCTs) investigating the use of baclofen in AUD; three using doses over 100 mg/day. Two additional RCTs have been completed but have not yet been published. Most trials used fixed dosing of 30–80 mg/day. The other approach involved titration until the desired clinical effect was achieved, or unwanted effects emerged. The maintenance dose varies widely from 30 to more than 300 mg/day. Baclofen may be particularly advantageous in those with liver disease, due to its limited hepatic metabolism and safe profile in this population. Patients should be informed that the use of baclofen for AUD is as an “off-label” prescription, that no optimal fixed dose has been established, and that existing clinical evidence on efficacy is inconsistent. Baclofen therapy requires careful medical monitoring due to safety considerations, particularly at higher doses and in those with comorbid physical and/or psychiatric conditions. Baclofen is mostly used in some European countries and Australia, and in particular, for patients who have not benefitted from the currently used and approved medications for AUD.

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Section: Baclofen (Off-label) Use For the Treatment Of Moderate To Sesupporting

confidence: 59%

The Use of Baclofen as a Treatment for Alcohol Use Disorder: A Clinical Practice Perspective

et al. 2019

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“…Emotional experiences during the day can alter sleep quality and macrostructure in many ways [ 13 ]. For example REM sleep has been reported to be enhanced [ 14 ], shortened [ 15 ] or unchanged due to different stressors. More fragmented sleep, longer sleep latency, shorter sleep duration also frequently occurs following stressful events [ 16 ].…”

Section: Introductionmentioning

confidence: 99%

Heart Rate and Heart Rate Variability during Sleep in Family Dogs (Canis familiaris). Moderate Effect of Pre-Sleep Emotions

Varga

Gergely

Galambos

et al. 2018

Animals

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Simple SummaryIt is common knowledge that negative emotions in humans are accompanied by both impaired subjective experience as well as maladaptive changes in behavior and physiology. The present paper investigates heart rate—one of the most commonly used emotion-related physiology measures—in the family dog, with the aim of uncovering its potential relationship with emotions. Sleep recordings were conducted following a positive versus a negative social interaction, as sleep alternations are one of the most conspicuous changes in response to negative affect. We observed differences in heart rate following the positive versus negative interactions, however these were only apparent during wakefulness, but not during sleep.AbstractThe domestic dog (Canis familiaris) has been shown to both excel in recognising human emotions and produce emotion-related vocalisations and postures that humans can easily recognise. However, little is known about the effect of emotional experiences on subsequent sleep physiology, a set of phenomena heavily interrelated with emotions in the case of humans. The present paper examines heart rate (HR) and heart rate variability (HRV) during dogs’ sleep, measures that are influenced by both positive and negative emotions in awake dogs. In Study I, descriptive HR and HRV data is provided on N = 12 dogs about the different sleep stages (wake, drowsiness, non-rapid eye movement (non-REM), REM; scoring based on electroencephalogram (EEG) data). We conclude that wakefulness is characterised by higher HR and lower HRV compared to all sleep stages. Furthermore, drowsiness is characterised by higher HR and lower HRV than non-REM and REM, but only if the electrocardiogram (ECG) samples are taken from the first occurrence of a given sleep stage, not when the longest periods of each sleep stage are analysed. Non-REM and REM sleep were not found to be different from each other in either HR or HRV parameters. In Study II, sleep HR and HRV measures are compared in N = 16 dogs after a positive versus negative social interaction (within-subject design). The positive social interaction consisted of petting and ball play, while the negative social interaction was a mixture of separation, threatening approach and still face test. Results are consistent with the two-dimensional emotion hypothesis in that following the intense positive interaction more elevated HR and decreased HRV is found compared to the mildly negative (lower intensity) interaction. However, although this trend can be observed in all sleep stages except for REM, the results only reach significance in the wake stage. In sum, the present findings suggest that HR and HRV are possible to measure during dogs’ sleep, and can potentially be used to study the effect of emotions not only during but also after such interactions.

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“…6,7) The majorˆnding being that REM sleep was enhanced signiˆcantly by the psychological stress of communication box, and these results diŠer from other psychological stress as listed in Table 1. Therefore, these discrepancies interested us, and we therefore conducted further research to clarify the possible mechanism.…”

Section: Conclusion and Implicationmentioning

confidence: 92%

“…Sleep recording was performed after 1 h of psychological stress. 6,7) Consequently total REM sleep was signiˆcantly enhanced due to the prolonged average duration of REM sleep episodes without aŠecting the total number of REM sleep episodes. However, there was no alteration of total NREM sleep and wakefulness in rats after 1 h of psychological stress ( Table 2).…”

Section: Sleep and Psychological Stressmentioning

confidence: 99%

Psychological Stress-induced Changes in Sleep Patterns and Its Generation Mechanism

Cui

Suemaru

et al. 2008

YAKUGAKU ZASSHI

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Recentˆndings have increasingly shown that sleep patterns are signiˆcantly in‰uenced by psychological stress, such as social defeat, novelty stress, contextual fear stress, and psychological stress induced by the communication box. However, the exact association between psychological stress and sleep is still poorly understood. Therefore, in the present paper we will review related work based on our recent investigations. We have previously reported that total rapid eye movement (REM) sleep, but not non-rapid eye movement (NREM) sleep that is enhanced by psychological stress induced by the communication box in rats . In past decades strong evidence showed that neurotransmitters play a key role in the variations of the sleep patterns, such as acetylcholine, GABA and others. In addition to neurotransmitters, the hypothalamic-pituitary-adrenal (HPA) axis is another important factor which in‰uences sleep patterns. Therefore, this review will focus on the involvement of the neurotransmitters and the HPA axis in the changes of sleep patterns in response to psychological stress.

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The Effect of Baclofen on Alterations in the Sleep Patterns Induced by Different Stressors in Rats

Cited by 7 publications

References 48 publications

The Use of Baclofen as a Treatment for Alcohol Use Disorder: A Clinical Practice Perspective

The Use of Baclofen as a Treatment for Alcohol Use Disorder: A Clinical Practice Perspective

Heart Rate and Heart Rate Variability during Sleep in Family Dogs (Canis familiaris). Moderate Effect of Pre-Sleep Emotions

Psychological Stress-induced Changes in Sleep Patterns and Its Generation Mechanism

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