Furosemide

Maxwell, Robert A.; Eckhardt, Shohreh B.

doi:10.1007/978-1-4612-0469-5_5

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2017

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“…Before the discovery of 4 , mercurial drugs associated with severe toxicity were the only available drugs to treat fluid retention. Few years later, in 1962, another sulfonamide, furosemide ( 5 ), was discovered as diuretic drug and is used to treat fluid retention and for the treatment of high blood pressure [ 10 ]. Tolbutamide ( 6 ), the first sulfonylurea anti-diabetic drug, was approved in the United States in 1957 for the treatment of type 2 diabetics [ 11 ].…”

Section: Introductionmentioning

confidence: 99%

N-Pyrrylarylsulfones with High Therapeutic Potential

2017

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This review illustrates the various studies made to investigate the activity of N-pyrrylarylsulfone containing compounds as potential antiviral, anticancer and SNC drugs. A number of synthetic approaches to obtain tetracyclic, tricyclic and non-cyclic compounds, and their biological activity with regard to structure–activity relationships (SARs) have been reviewed. The literature reviewed here may provide useful information on the potential of N-pyrrylarylsulfone pharmacophore as well as suggest concepts for the design and synthesis of new N-pyrrylarylsulfone based agents.

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Section: Introductionmentioning

confidence: 99%