N-Pyrrylarylsulfones with High Therapeutic Potential

Famiglini, Valeria; Castellano, Sabrina; Silvestri, Romano

doi:10.3390/molecules22030434

Cited by 8 publications

(4 citation statements)

References 79 publications

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“…The following special issue of Molecules is in fact a nice example of this multitude of possible applications of the sulfonamides, with the wide range of targets to which they bind, diverse synthetic procedures and pharmacological applications, some of which highly innovative, for many representatives of this interesting class of pharmacologic agents. The first contribution is a nice review article [ 31 ] from Silvestri’s group, dealing with N-pyrrylarylsulfones, a class of pharmacological agents discovered using the sulfonamides as leads, through a simplification of the functional group. The extensive review presents both the many synthetic procedures for obtaining representatives of this class, as well as many relevant examples of their biological activity as antiviral, anticancer and SNC drugs [ 31 ].…”

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confidence: 99%

“…The first contribution is a nice review article [ 31 ] from Silvestri’s group, dealing with N-pyrrylarylsulfones, a class of pharmacological agents discovered using the sulfonamides as leads, through a simplification of the functional group. The extensive review presents both the many synthetic procedures for obtaining representatives of this class, as well as many relevant examples of their biological activity as antiviral, anticancer and SNC drugs [ 31 ].…”

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confidence: 99%

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Special Issue: Sulfonamides

Supuran

2017

Molecules

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The sulfonamides and their structurally related derivatives, such as the sulfamates and sulfamides, possess the general formula A-SO2NHR, in which the functional group is either directly bound to an aromatic, heterocyclic, aliphatic, or sugar scaffold (of type A), or appended to such a scaffold via a heteroatom, most frequently oxygen or nitrogen (leading thus to sulfamates and sulfamides, respectively) [...]

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Special Issue: Sulfonamides

Supuran

2017

Molecules

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“…The reaction was also carried out with microwave activation without solvent and additives at 150 • C [53]. The method may be of interest for the synthesis of antiviral drugs, since antiviral biological activity is known for sulfonamide-containing pyrroles [55].…”

Section: Antiviral Sulfonamide Derivativesmentioning

confidence: 99%

Sulfonamides with Heterocyclic Periphery as Antiviral Agents

Moskalik

2022

Molecules

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Sulfonamides are the basic motifs for a whole generation of drugs from a large group of antibiotics. Currently, research in the field of the new sulfonamide synthesis has received a “second wind”, due to the increase in the synthetic capabilities of organic chemistry and the study of their medical and biological properties of a wide spectrum of biological activity. New reagents and new reactions make it possible to significantly increase the number of compounds with a sulfonamide fragment in combination with other important pharmacophore groups, such as, for example, a wide class of N-containing heterocycles. The result of these synthetic possibilities is the extension of the activity spectrum—along with antibacterial activity, many of them exhibit other types of biological activity. Antiviral activity is also observed in a wide range of sulfonamide derivatives. This review provides examples of the synthesis of sulfonamide compounds with antiviral properties that can be used to develop drugs against coxsackievirus B, enteroviruses, encephalomyocarditis viruses, adenoviruses, human parainfluenza viruses, Ebola virus, Marburg virus, SARS-CoV-2, HIV and others. Since over the past three years, viral infections have become a special problem for public health throughout the world, the development of new broad-spectrum antiviral drugs is an extremely important task for synthetic organic and medicinal chemistry. Sulfonamides can be both sources of nitrogen for building a nitrogen-containing heterocyclic core and the side chain substituents of a biologically active substance. The formation of the sulfonamide group is often achieved by the reaction of the N-nucleophilic center in the substrate molecule with the corresponding sulfonylchloride. Another approach involves the use of sulfonamides as the reagents for building a nitrogen-containing framework.

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“…Since diaryl sulfone and N-phenylbenzenesulfonamide derivatives have been synthesized in this work, in this section, we will point out the importance of these compounds as well as a brief discussion covering other synthetic strategies for the synthesis of these compounds. Diaryl sulfones are useful intermediates due to their interesting biological [13][14][15][16][17] and chemical [18][19][20] properties. Diaryl sulfone derivatives are either an antibiotic like dapsone for the treatment of leprosy 13 or have anti-HIV-1 activity like 2-nitrophenyl phenyl sulfone, 14 N-(5-bromo-3-((4-chlorophenyl)sulfonyl)thiophen-2-yl) acetamide, 15 2-amino-6-arylsulfonylbenzonitrile, 16 pyrrylarylsulfone 17 and indolylaryl sulfones 14 (Fig.…”

Section: Introductionmentioning

confidence: 99%