Furans and their Benzo Derivatives: Applications

Keay, Brian A.; Hopkins, J. Matthew; Dibble, Peter W.

doi:10.1016/b978-008044992-0.00308-4

Cited by 59 publications

(32 citation statements)

References 123 publications

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“…2e5 Many naturally occurring furans have exhibited considerable biological activities, such as antitumor and cytotoxic properties, 6 as well as antimicrobial, 7 antispasmodic, 8 and several other potentially useful activities. 9,10 In addition, furans are also present in commercially important products, such as agrochemical bioregulators, essential oils, cosmetics, dyes, photosensitizers, flavoring and fragrance compounds. 10,11 This broad range of applications has made the development of new and efficient furan synthesis very valuable.…”

Section: Introductionmentioning

confidence: 99%

“…9,10 In addition, furans are also present in commercially important products, such as agrochemical bioregulators, essential oils, cosmetics, dyes, photosensitizers, flavoring and fragrance compounds. 10,11 This broad range of applications has made the development of new and efficient furan synthesis very valuable. Consequently, a variety of furan syntheses have been reported in the literature.…”

Section: Introductionmentioning

confidence: 99%

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Synthesis of 2-(alkylamino)-5-{alkyl[(2-oxo-2H-chromen-3-yl)carbonyl]amino}-3,4-furandicarboxylates using a multi-component reaction in water

et al. 2010

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Synthesis of 2-(alkylamino)-5-{alkyl[(2-oxo-2H-chromen-3-yl)carbonyl]amino}-3,4-furandicarboxylates using a multi-component reaction in water

et al. 2010

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“…Substituted furans are important and ubiquitous structural units present in large number of natural compounds [1], pharmaceuticals [1,2] and have been widely used as synthetic building blocks for the synthesis of many organic materials [3,4]. Their synthesis, however, still remains a challenge for synthetic chemists.…”

Section: Introductionmentioning

confidence: 99%

An Efficient Chemoselective Reduction of Furan Series Unsaturated Dinitriles

Bobáľ

Bobáľová

2013

Molecules

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An efficient reduction of double bonds conjugated with nitrile groups and acid or base sensitive furan rings with 2-phenylbenzimidazoline generated in situ has been successfully accomplished with high yields and excellent selectivity. The employed reducing agent was prepared in one step from ordinary chemicals. The other advantages of the presented method include mild and convenient reaction conditions, a benign and cost effective reagent, simple work-up and separation of the products. As this process does neither affect cyano and nitro groups nor furan rings, it is a valuable alternative when metal-catalyzed hydrogenations or borohydride reductions have failed.

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“…1 These compounds are an important class of heterocyclic compounds that are known to possess important biological properties. Substituted benzofurans have found applications as oxidant, 2 antifungal, 3 antitumor, 4 antioxidants, a variety of drugs and in other fields of chemistry and agriculture.…”

mentioning

confidence: 99%

Clean and Catalyst-Less Electrosynthesis of Benzofurans viap-Phenylenediamine Oxidation in the Presence of Barbiturics

Asghari¹,

Ghaderi²,

Ameri³

et al. 2014

J. Electrochem. Soc.

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Electrochemical oxidation of p-phenylenediamine (1a) was studied in the presence of barbituric acid (3a) and thiobarbituric acid (3b) as nucleophiles in a mixture of phosphate buffer solution (pH 6.0, 0.15 M) and ethanol (80:20 v:v) using cyclic voltammetry and controlled-potential coulometric techniques. The results show that electrochemically generated cyclohexa-2, 5-diene-1, 4-diimine (2a) participates in a 1, 4-Michael-type addition reaction with barbituric acid derivatives via an ECEC mechanism to form new benzofurans (6a-b). The electrochemical synthesis of new benzofurans has been successfully performed in good yields and high purity using a facile, one-pot, clean and non-catalyst method by 3 carbon electrodes in an undivided cell, without using any hazardous solvents.

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Furans and their Benzo Derivatives: Applications

Cited by 59 publications

References 123 publications

Synthesis of 2-(alkylamino)-5-{alkyl[(2-oxo-2H-chromen-3-yl)carbonyl]amino}-3,4-furandicarboxylates using a multi-component reaction in water

Synthesis of 2-(alkylamino)-5-{alkyl[(2-oxo-2H-chromen-3-yl)carbonyl]amino}-3,4-furandicarboxylates using a multi-component reaction in water

An Efficient Chemoselective Reduction of Furan Series Unsaturated Dinitriles

Clean and Catalyst-Less Electrosynthesis of Benzofurans viap-Phenylenediamine Oxidation in the Presence of Barbiturics

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