Funktionelle Erkrankungen des Gastrointestinaltrakts

Keller, Jutta; Layer, Peter; Fried, M.

doi:10.1007/s11377-012-0739-x

Cited by 7 publications

(3 citation statements)

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“…To our knowledge, there are not any data that we can compare our leptin/ghrelin ratio results to, but different ghrelin and leptin concentrations have been demonstrated to be dependent on nutritional status [11], as well as on meal composition [25]. We decided to analyse leptin and ghrelin together, as the leptin/ghrelin ratio, since these are two of the main hormones that influence the metabolic status of the body, appetite and hunger sensations, etc., which are an effect of the hormone interactions, rather than an effect of only one individual hormone’s action.…”

Section: Discussionmentioning

confidence: 99%

“…Ghrelin plays an important role in short-term appetite regulation and is characterized by increased concentrations before meal intake, and decreased levels after meal ingestion [10]. The orexigenic action of ghrelin is based on increasing gastrointestinal peristalsis and reducing insulin secretion, and despite its appetite stimulation effects, it was found that obesity, type 2 diabetes mellitus and metabolic syndrome are associated with lower serum ghrelin concentrations [7, 8, 11].…”

Section: Introductionmentioning

confidence: 99%

“…Therefore, in the analysis of hormonal response after meal intake, it is reasonable to combine these two hormones together, and due to their interaction, the ratio of their concentrations (leptin/ghrelin ratio) is defined as a hunger signal, called the “ghrelin-leptin tango” [13]. It has been found that leptin and ghrelin concentrations depend on body weight and postprandially, on meal composition, but studies on their ratio are very limited with varying results [11, 14, 15].…”

Section: Introductionmentioning

confidence: 99%

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The relationship between the leptin/ghrelin ratio and meals with various macronutrient contents in men with different nutritional status: a randomized crossover study

Adamska-Patruno

Ostrowska

Gościk

et al. 2018

Nutr J

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BackgroundHormones, which influence satiety and hunger, play a significant role in body energy balance regulation. Ghrelin is a peptide that plays an important role in short-term appetite regulation, whereas leptin is a factor that controls long-term energy balance and is considered as a satiety hormone. The aim of this study was to evaluate the leptin/ghrelin ratio in a fasting state and after the intake of meals with varying macronutrient contents and to assess the possible differences between normal body weight and overweight/obese men.MethodsWe examined 46 healthy adult men (23 with normal body weight and 23 overweight/obese) aged 21–58, who were divided into two groups. In the crossover study, participants received isocaloric (450 kcal) meals with different macronutrient contents: men from the first group received high-carbohydrate (HC) and normo-carbohydrate (NC) meals, and in the second group, participants received high-carbohydrate and high-fat (HF) meals. The ratio of leptin/ghrelin levels was calculated from leptin and total ghrelin serum concentrations in a fasting state and 30, 60, 120, 180 and 240 min after meal intake. One-way ANOVA and Wilcoxon signed-rank tests were carried out. The normality of the variable distribution was checked with the Shapiro–Wilk test, the homogeneity of variances was verified with the Levene test, and the false discovery rate p-value adjustment method was used.ResultsThe leptin/ghrelin ratio was significantly higher in overweight/obese men than individuals with normal body weight in a fasting state, as well as postprandially. We observed trends towards a higher leptin/ghrelin ratio values from the 60 min after HC-meal intake compared to the NC- and HF-meals in normal body weight participants, while in overweight/obese men, we did not note any significant differences dependent on the meal type.ConclusionsWe have observed a significantly different postprandial leptin/ghrelin ratio in normal body weight and overweight/obese men, and our results suggest that in men with normal body weight, a greater feeling of satiety may occur after high-carbohydrate meal intake, which was not noted in the overweight/obese individuals.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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The relationship between the leptin/ghrelin ratio and meals with various macronutrient contents in men with different nutritional status: a randomized crossover study

Adamska-Patruno

Ostrowska

Gościk

et al. 2018

Nutr J

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High‐Amylose Cornstarch Variably Affects Food Intake and Body Composition of Rats When Substituted to Standard versus a Moderately High‐Fat High‐Sugar Diet

2020

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The addition of resistant starch (RS) to a food lowers its energy density but its impact on appetite, food intake (FI), and body composition is not well understood. This study explores the effect of RS from high‐amylose cornstarch on FI, body composition, mineral‐absorption, and inflammatory markers when tested simultaneously in control (C) and moderately increased fat and sugar (HFHS) diets. Four groups of weanling rats are fed C, C + RS, HFHS, or HFHS + RS diets and their FI and body weight (BW) are recorded. After four weeks blood serum, abdominal fat, total gut weight, cecal content, and feces are collected and analyzed. FI increases (p < 0.000) in C + RS (440 ± 29 g) versus C (396 ± 40 g) while it decreases (p = 0.001) in HFHS + RS (419 ± 44 g) versus HFHS (481 ± 35 g). Both BW and abdominal fat decrease significantly in HFHS + RS (212 ± 39 g) versus HFHS (247 ± 28 g) (p = 0.032) and (7 ± 2.27 g) versus (10 ± 2.41 g) (p < 0.000), respectively but remains unchanged in C + RS versus C. Percent calcium absorption selectively increases in HFHS + RS (p <0.000) versus HFHS. In conclusion, RS effectively reduces FI, weight gain, abdominal fat‐mass, and enhanced mineral absorption differentially when added to standard or a moderately HFHS diet of growing rats.

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Brain responses to nutrients are severely impaired and not reversed by weight loss in humans with obesity: a randomized crossover study

et al. 2023

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Funktionelle Erkrankungen des Gastrointestinaltrakts

Cited by 7 publications

References 0 publications

The relationship between the leptin/ghrelin ratio and meals with various macronutrient contents in men with different nutritional status: a randomized crossover study

The relationship between the leptin/ghrelin ratio and meals with various macronutrient contents in men with different nutritional status: a randomized crossover study

High‐Amylose Cornstarch Variably Affects Food Intake and Body Composition of Rats When Substituted to Standard versus a Moderately High‐Fat High‐Sugar Diet

Brain responses to nutrients are severely impaired and not reversed by weight loss in humans with obesity: a randomized crossover study

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