Fungicidal amounts of antifungals are released from impregnated denture lining material for up to 28 days

Chlorhexidine is a highly effective topical broad-spectrum agent against Candida spp.

“…It has also been shown to have superior efficacy against Candida biofilms compared with FLZ in vitro and in vivo [13,[18][19][20][21]. Furthermore, it can be used to impregnate denture liners to act as a long-term self-release drug carrier [22].…”

Impregnation with antimicrobials challenge bonding properties and water sorption behaviour of an acrylic liner

“…4 Incorporation of different antifungal agents in polymeric systems used in dentures has shown remarkable efficiency. 1,2,5 Various polymeric systems have been suggested for the controlled release of bioactive agents in the oral cavity. 1,6 Many of these systems are based on polymethylmethacrylate acrylic system (PMMA).…”

Impregnation with antimicrobials has an impact on degree of conversion and colour stability of acrylic liner

“…Although high colour change values ΔE*ab were measured for the impregnated PEM/THFM, it is still acceptable for short term use as these values are within or even lower than that recoded for permanent denture liners 23) . All antimicrobial agents and formulations that were tested in the current study showed remarkable antifungal activity after being leached from PEM/THFM in a previous study 7) . These earlier findings highlight the importance of testing the degree of conversion and colour change to investigate the serviceability and durability of the suggested delivery.…”

“…Water incubation of PEM/THFM discs impregnated with fluconazole or chlorhexidine has been shown to result in release of highly fungicidal amounts of these drugs into the water 7) . As incorporation of drugs may impact the physical and chemical properties of the material and its serviceability, we set out to evaluate the impact of this on two important clinical properties: the degree of conversion (DC) and colour stability 20,23) .…”

“…These systems are predominantly based on polymethylmethacrylate (PMMA) 2,6) . A number of bioactive delivery systems based on a cold-cure poly (ethyl methacrylate)/tetrahydrofurfuryl methacrylate (PEM/THFM) polymer system have been introduced with promising results 1,3,5,7) . This polymer can be used as a denture lining material or as a base for dental appliances.…”