Impregnation with antimicrobials has an impact on degree of conversion and colour stability of acrylic liner

Abstract

This study investigated the impact of impregnation of a poly(ethyl methacrylate) /tetrahydrofurfuryl methacrylate (PEM/THFM) polymer with chlorhexidine or fluconazole on the degree of conversion (DC) and colour stability (ΔE). The DC of uncured (0 h) and cured (24 h) samples was analysed by Fourier transform infrared spectroscopy (FTIR) and colour stability was analysed colorimetrically. The DC percentage of the control samples was significantly greater than those containing chlorhexidine and fluconazole (p≤0.05). The control discs exhibited only slight colour change compared to the impregnated discs which showed marked colour change (p≤0.05). A strong negative correlation between the extent of colour change and the degree of conversion was detected (r=0.97). The DC and colour stability were influenced by the addition of chlorhexidine or fluconazole. However, the final values were comparable to other commonly used acrylic liners and within acceptable ranges. PEM/THFM can be considered as a biocompatible drug delivery system.

Chlorhexidine loading of acrylic reline resins – Microhardness and flexural strength after thermal aging

“…In spite of incorporation of resin materials, with compounds like fluconazole, silver -zinc zeolite, fluoroalkyl methacrylate, methacryloyloxyundecylpyridinium bromide or TiO 2 and SiO 2 nanoparticles, have been studied, 15,48,53 CHX has shown a more efficient candidacidal effect when loaded in acrylic resins. [22][23][24]27,33,37,42 The selection of the tested CHX concentrations was based on the results of previous mechanical studies. 44,45 Unlike Ufi Gel Hard, loading the Kooliner and the Probase Cold with 10% CHX negatively influences microhardness and flexural strength of these reline resins.…”

“…23,26,32 CHX suppress the adherence of Candida albicans to cells or acrylic surfaces and, for this reason, can inhibit Candida -related infections. 27,[33][34][35][36][37] CHX has shown to have a good performance both on releasing and microbiological tests. 22,35,[38][39][40][41][42] When loaded into acrylic resins, CHX has shown higher effectiveness in microbiological tests compared to other agents such as fluconazole and nystatin.…”

Candidacidal effect of fluconazole and chlorhexidine released from acrylic polymer

“…However, despite a reduction in all tested physicomechanical properties (degree of conversion, shear strength, water sorption and colour stability), all values are still within acceptable ranges and similar to those reported for some other acrylic liners when tested without impregnation. 28,29 As this is an in vitro study, further clinical studies are warranted to determine its clinical applicability.…”

Chlorhexidine-loaded functionalized mesoporous MCM-41 poly(methylmethacrylate) based composites with Candida antibiofilm activity

“…[6][7][8][9] These materials show a delay in biolm formation compared to conventional resins or composites but some of them show polymer leakage, reduced polymerization degree and loss of their effectiveness over time. [10][11][12] Recently, mesoporous ordered silicates, such as MCM-41 and SBA-15, have been proposed as components for dental polymer silica composites and their presence in moderate amount in the polymer matrix improved composite hardness. [13][14][15] Mesoporous ordered silicates are inorganic materials synthesized in the presence of surfactants which act as templates for poly-condensation of silicic species, a source of silica, a solvent and a catalyst.…”