Fungemia in Neonates: Report of 80 Cases From Seven University Hospitals

Virulence of Candida parapsilosis, Candida orthopsilosis, and Candida metapsilosis in reconstituted human tissue models

“…Candida parapsilosis is a commensal of skin surfaces that is emerging as a major invasive pathogen of humans, particularly in the setting of a compromised immune system or the presence of intravenous catheters (Fridkin et al, 2006;Krcmery et al, 2000;Pagano et al, 1999;Pfaller et al, 2001). RHT systems for the study of C. albicans cutaneous and oral (Schaller et al, 1999) infections have provided useful insights into the virulence of this pathogenic species, and a recent study showed a significant difference in the invasiveness of several Candida species in a recombinant oral tissue model (Jayatilake et al, 2006).…”

“…In fact, C. parapsilosis is now the second most commonly isolated Candida species from blood cultures in USA, Canada and Latin America, and in some European hospitals C. parapsilosis even outranks C. albicans (Fridkin et al, 2006;Krcmery et al, 2000;Pagano et al, 1999;Pfaller et al, 2001). C. parapsilosis typically is a commensal of human skin and is considered to be of low pathogenicity in the setting of intact integument.…”

Fatal disseminated Acremonium strictum infection in a preterm newborn: a very rare cause of neonatal septicaemia

“…In addition, neonates with fungal sepsis have significantly longer hospitalization and higher rates of mechanical ventilation, umbilical vein catheterization, previous treatment with antibacterial agents and prior use of parenteral nutrition that includes intravenous lipid (Krcmery et al 2000;Makhoul et al, 2001), which may increase susceptibility. Predisposing factors and conditions in our patient included extreme prematurity, prolonged total parenteral nutrition, previous antibiotic treatment and umbilical vein catheterization.…”

Candida parapsilosis, an Emerging Fungal Pathogen

“…In fact, reports indicate that C. parapsilosis is often the second most commonly isolated Candida species from blood cultures (5,34,51,52,54,90,144,177,213,215,231), and C. parapsilosis even outranks Candida albicans in some European (213), Asian (186,189), and South American (174) hospitals.…”