Fungal siderophores: structures, functions and applications

Renshaw, Joanna C.; Robson, Geoff; Trinci, Anthony P. J.; Wiebe, Marilyn G.; Livens, Francis R.; Collison, David; Taylor, Raymond L.

doi:10.1017/s0953756202006548

Cited by 317 publications

(234 citation statements)

References 172 publications

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“…Intriguingly, unique behavior, consistent with a recently proposed solution-phase structure, was observed for the highly preferred iderophores are low molecular weight, highaffinity iron-chelating agents produced by bacteria, fungi, and marine organisms to solubilize and scavenge Fe 3ϩ from the environment [1][2][3][4]. A wide structural versatility has been found in the more than 200 siderophores reported so far [4]. These molecules can be classified into two main types with respect to their iron-binding groups: catecholate and hydroxamate.…”

supporting

confidence: 78%

“…These molecules can be classified into two main types with respect to their iron-binding groups: catecholate and hydroxamate. For example, petrobactin biosynthesized by both the marine bacterium Marinobacter hydrocarbonoclasticus [5] and by Bacillus anthracis [6,7] is a catecholate-type siderophore, whereas most siderophores (such as fusarinines, corogens, and ferrichromes) produced by fungi belong to the hydroxamate family [4].…”

mentioning

confidence: 99%

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Collision-activated dissociation, infrared multiphoton dissociation, and electron capture dissociation of the Bacillus anthracis siderophore petrobactin and its metal ion complexes

Liu

Håkansson

Lee

et al. 2007

J. Am. Soc. Mass Spectrom.

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Siderophores are high-affinity iron-chelating ligands produced by microorganisms to scavenge vital Fe 3ϩ from the environment. Thus, siderophores constitute potential therapeutic targets and their structural determination is important for exploiting their therapeutic value. Here, the virulence-associated siderophore petrobactin from Bacillus anthracis was characterized with electron capture dissociation (ECD). Fragmentation of doubly protonated petrobactin was investigated and compared to sustained off-resonance irradiation collision-activated dissociation (SORI CAD) and infrared multiphoton dissociation (IRMPD) of both the singly and doubly protonated species. These experiments demonstrate that ECD provides additional information (complementary bond cleavages) on the structure of petrobactin compared to both SORI CAD and IRMPD. Furthermore, complexes of petrobactin with divalent (Ca , and Co 2ϩ ) and trivalent (Fe 3ϩ and Ga 3ϩ ) metal cations were also subjected to SORI CAD and ECD. Again, most structural information was obtained from the ECD spectra. However, significant differences were found in both SORI CAD and ECD of metal complexes, dependent on the nature of the metal ion. Intriguingly, unique behavior, consistent with a recently proposed solution-phase structure, was observed for the highly preferred Fe 3ϩ -petrobactin complex. (J Am Soc Mass Spectrom 2007, 18, 842-849)

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supporting

confidence: 78%

mentioning

confidence: 99%

Collision-activated dissociation, infrared multiphoton dissociation, and electron capture dissociation of the Bacillus anthracis siderophore petrobactin and its metal ion complexes

Liu

Håkansson

Lee

et al. 2007

J. Am. Soc. Mass Spectrom.

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“…2). The novel methylated coprogens bring the number of coprogen derivatives to a total of fourteen (Renshaw et al, 2002).…”

Section: Magnaporthe Grisea Produces Siderophores Of the Hydroxamatementioning

confidence: 99%

Siderophores Produced by Magnaporthe grisea in the Presence and Absence of Iron

Antelo

Hof

Welzel

et al. 2006

Zeitschrift Für Naturforschung C

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An analysis of siderophores produced by Magnaporthe grisea revealed the presence of one intracellular storage siderophore, ferricrocin, and four coprogen derivatives secreted into the medium under iron depletion. Structural analysis showed that the compounds are coprogen, coprogen B, 2-N-methylcoprogen and 2-Nmethylcoprogen B. Siderophore production under low and high iron conditions was quantified.

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“…Ferrichromes are further divided into five groups depending on the side chain of the hydroxamate functional and cis-anhydromevalonyl (ferrirhodin) (Renshaw et al, 2002;Winkelmann, 2007). Common soil fungi that produce ferrichrome type siderophores are U. sphaerogena for ferrichrome (Emery, 1971), Aspergillus fumigatus for ferricrocin (Wallner et al, 2009), Neurospora crassa for tetraglycylferrichrome (Winkelmann, 2007) and Cenococcum geophilum and Hebeloma crustuliniforme for ferrichrysin (Martino and Perotto, 2010).…”

Section: Agrobacterium Tumefaciens; Dihydroxybenzoic Acid By Erwiniamentioning

confidence: 99%

Siderophore Production by Microorganisms Isolated From a Podzol Soil Profile

Ahmed

Holmström

2014

Geomicrobiology Journal

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Siderophore producing bacteria/actinobacteria and fungi were isolated from O-(organic), E-(eluvial), B-(upper illuvial), and C-(parent material) horizons of podzol soil. Siderophores were isolated and hydroxamate type siderophores were detected and quantitated by high-performance liquid chromatography coupled to electrospray ionization mass spectrometry. The molecular identification of siderophore producing isolates showed that there was a high diversity of fungal and bacterial/actinobacterial species throughout the soil profile. The isolated bacteria/actinobacteria showed different abilities in the production of ferrioxamines (E, B, G and D). Moreover, the isolated fungal species showed great variety in the production of ferrichromes, coprogens and fusarinines.

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Fungal siderophores: structures, functions and applications

Cited by 317 publications

References 172 publications

Collision-activated dissociation, infrared multiphoton dissociation, and electron capture dissociation of the Bacillus anthracis siderophore petrobactin and its metal ion complexes

Collision-activated dissociation, infrared multiphoton dissociation, and electron capture dissociation of the Bacillus anthracis siderophore petrobactin and its metal ion complexes

Siderophores Produced by Magnaporthe grisea in the Presence and Absence of Iron

Siderophore Production by Microorganisms Isolated From a Podzol Soil Profile

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