Fungal secondary metabolites as harmful indoor air contaminants: 10 years on

Miller, J. David; McMullin, David

doi:10.1007/s00253-014-6178-5

Cited by 73 publications

(55 citation statements)

References 116 publications

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“…Aspergillus species have also been used as heterologous producers of proteins and exometabolites and for bioremediation. Species of Aspergillus can also have negative effects and be pathogenic (Buzina 2013;Sugui et al 2014a, b), give health problems in buildings (Miller and McMullin 2014) and deteriorate other materials.…”

Section: Introductionmentioning

confidence: 97%

Chemodiversity in the genus Aspergillus

Frisvad

Larsen

2015

Appl Microbiol Biotechnol

111

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Isolates of Aspergillus species are able to produce a large number of secondary metabolites. The profiles of biosynthetic families of secondary metabolites are species specific, whereas individual secondary metabolite families can occur in other species, even those phylogenetically and ecologically unrelated to Aspergillus. Furthermore, there is a high degree of chemo-consistency from isolate to isolate in a species even though certain metabolite gene clusters are silenced in some isolates. Genome sequencing projects have shown that the diversity of secondary metabolites is much larger in each species than previously thought. The potential of finding even further new bioactive drug candidates in Aspergillus is evident, despite the fact that many secondary metabolites have already been structure elucidated and chemotaxonomic studies have shown that many new secondary metabolites have yet to be characterized. The genus Aspergillus is cladistically holophyletic but phenotypically polythetic and very diverse and is associated to quite different sexual states. Following the one fungus one name system, the genus Aspergillus is restricted to a holophyletic clade that include the morphologically different genera Aspergillus, Dichotomomyces, Phialosimplex, Polypaecilum and Cristaspora. Secondary metabolites common between the subgenera and sections of Aspergillus are surprisingly few, but many metabolites are common to a majority of species within the sections. We call small molecule extrolites in the same biosynthetic family isoextrolites. However, it appears that secondary metabolites from one Aspergillus section have analogous metabolites in other sections (here also called heteroisoextrolites). In this review, we give a genus-wide overview of secondary metabolite production in Aspergillus species. Extrolites appear to have evolved because of ecological challenges rather than being inherited from ancestral species, at least when comparing the species in the different sections of Aspergillus. Within the Aspergillus sections, secondary metabolite pathways seem to inherit from ancestral species, but the profiles of these secondary metabolites are shaped by the biotic and abiotic environment. We hypothesize that many new and unique section-specific small molecule extrolites in each of the Aspergillus will be discovered.

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Section: Introductionmentioning

confidence: 97%

Chemodiversity in the genus Aspergillus

Frisvad

Larsen

2015

Appl Microbiol Biotechnol

111

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“…leaking water pipes, flooding, faulty building constructions, or severe and prolonged condensation) many building materials become good substrates for certain fungi. These growing fungi can cause adverse effects not only on the buildings but also to their occupants (Samson et al., 1994, WHO, 2009, Samson et al., 2010, Flannigan and Miller, 2011, Andersen et al., 2011, Miller and McMullin, 2014). Members of the genus Chaetomium are capable of colonising various substrates and are well-known for their ability to degrade cellulose and to produce a variety of bioactive metabolites.…”

Section: Introductionmentioning

confidence: 99%

Diversity and taxonomy ofChaetomiumand chaetomium-like fungi from indoor environments

Wang

Houbraken

Groenewald

et al. 2016

Studies in Mycology

139

140

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During a study of indoor fungi, 145 isolates belonging to Chaetomiaceae were cultured from air, swab and dust samples from 19 countries. Based on the phylogenetic analyses of DNA-directed RNA polymerase II second largest subunit (rpb2), β-tubulin (tub2), ITS and 28S large subunit (LSU) nrDNA sequences, together with morphological comparisons with related genera and species, 30 indoor taxa are recognised, of which 22 represent known species, seven are described as new, and one remains to be identified to species level. In our collection, 69 % of the indoor isolates with six species cluster with members of the Chaetomium globosum species complex, representing Chaetomium sensu stricto. The other indoor species fall into nine lineages that are separated from each other with several known chaetomiaceous genera occurring among them. No generic names are available for five of those lineages, and the following new genera are introduced here: Amesia with three indoor species, Arcopilus with one indoor species, Collariella with four indoor species, Dichotomopilus with seven indoor species and Ovatospora with two indoor species. The generic concept of Botryotrichum is expanded to include Emilmuelleria and the chaetomium-like species B. muromum (= Ch. murorum) in which two indoor species are included. The generic concept of Subramaniula is expanded to include several chaetomium-like taxa as well as one indoor species. Humicola is recognised as a distinct genus including two indoor taxa. According to this study, Ch. globosum is the most abundant Chaetomiaceae indoor species (74/145), followed by Ch. cochliodes (17/145), Ch. elatum (6/145) and B. piluliferum (5/145). The morphological diversity of indoor Chaetomiaceae as well as the morphological characteristics of the new genera are described and illustrated. This taxonomic study redefines the generic concept of Chaetomium and provides new insight into the phylogenetic relationships among different genera within Chaetomiaceae.

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“…In the last years, several studies have pointed out the critical microbiological contribution towards airway infections, impaired immune function, bronchitis, asthma, recurrent airway infections and extreme fatigue (Miller and McMullin, 2014;Nielsen, 2003;WHO, 2009). Inside libraries and archives, for example, the management of increasing fungal contaminations due to inadequate conservations, such as malfunction of air conditioning systems, lack of cleanliness, exchange of contaminated collections or materials, has become a complex and expensive problem, for book conservation but also for the health of workers and students (Flannigan and Miller, 2011;Micheluz et al,F o r P e e r R e v i e w 4…”

Section: Introductionmentioning

confidence: 99%

Fungal secondary metabolite analysis applied to Cultural Heritage: the case of a contaminated library in Venice

Micheluz

Sulyok²,

Manente

et al. 2016

WMJ

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The secondary metabolite production of several fungal strains of Aspergillus creber, Aspergillus jensenii, Aspergillus penicillioides, Aspergillus protuberus, Aspergillus vitricola, Cladosporium cladosporioides, Eurotium chevalieri, Eurotium halophilicum, Penicillium brevicompactum and Penicillium chrysogenum were characterised by liquid chromatography tamdem mass spectometry. All fungi were isolated from both air and book covers as well as from settled dust from a contaminated library in Venice (Italy). For A. creber and A. jensenii, we identified sterigmatocystin, methoxysterigmatocystin, versicolorin A and related precursors/side metabolites from the biosynthetic pathways. Deoxybrevianamid E, neoechinulin A, pseurotin A and D, and rugulusovin were principally detected from the strains of E. halophilicum, an emerging fungal species implicated in book contaminations in specific indoor niches. The analysis of settled dust showed a wide range of toxic or bioactive fungal metabolites. Forty-five different metabolites were identified in different concentrations; in particular, high amounts of asperglaucide, alamethicin, andrastin A, terrecyclic acid and neoechinulin A were detected. Also one bacterial metabolite, chloramphenicole was detected. This study increases the knowledge about metabolite production of several fungal species, as well as on the indoor presence of fungi that are not detected by aerobiological sampling. These results emphasise how routine dusting operations are necessary and essential in order to prevent further microbiological developments in library environments.

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Fungal secondary metabolites as harmful indoor air contaminants: 10 years on

Cited by 73 publications

References 116 publications

Chemodiversity in the genus Aspergillus

Chemodiversity in the genus Aspergillus

Diversity and taxonomy ofChaetomiumand chaetomium-like fungi from indoor environments

Fungal secondary metabolite analysis applied to Cultural Heritage: the case of a contaminated library in Venice

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