Fungal Infections

Chandler, Francis W.; Watts, John

doi:10.1007/978-1-4757-3932-9_8

Cited by 25 publications

(25 citation statements)

References 310 publications

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“…Hematogenous extrapulmonary dissemination occurs especially to the brain, liver and kidneys [3]. However, little is known about the way in which this fungal disease influences pulmonary function and general physiology.…”

Section: Introductionmentioning

confidence: 99%

Pathophysiology of unilateral pulmonary aspergillosis in an experimental rat model

Becker¹,

Marie²,

Fens³

et al. 2006

Med Mycol

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Because little is known about the pathophysiology of invasive pulmonary aspergillosis (IPA), we examined changes in pulmonary and general physiology during this disease in an animal model. In a model of fatal left-sided IPA, 19 persistently neutropenic rats were monitored for clinical signs including body temperature, body weight and respiratory distress. A separate group of nine rats with IPA was used for measurements of arterial blood pressure, arterial O2 and CO2 pressure, lung compliance and surfactant function. Body temperature and body weight decreased, whereas respiratory distress increased during progression of the disease. Compared to uninfected controls, in rats with IPA arterial blood pressure and lung compliance were significantly lower, and left lung minimal surface tension was significantly higher. Right lung surfactant function was not affected. Arterial O2 and CO2 pressures were not different between rats with IPA and uninfected controls. Infection with Aspergillus fumigatus in neutropenic rats resulted in hypothermia, body weight loss and respiratory distress. Loss of left lung function was probably compensated by the uninfected right lung, even in a late stage of the disease. Circulatory failure was a major feature in the terminal phase of the infection.

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Section: Introductionmentioning

confidence: 99%

Pathophysiology of unilateral pulmonary aspergillosis in an experimental rat model

Becker¹,

Marie²,

Fens³

et al. 2006

Med Mycol

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“…Cytologically, the salivary gland lesion resembled a classic pulmonary histoplasmoma with a central region of necrotic material and fungal organisms. [14][15][16] Organisms were numerous in this case, which is not unexpected in AIDS. Secondary infection by Candida most likely occur-red by spread from the oropharynx, where Candida can be a normal colonizer.…”

Section: Discussionmentioning

confidence: 91%

Fine‐needle aspiration biopsy of salivary gland mycoses

Raab

Cohen

1994

Diagnostic Cytopathology

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This report details the fine-needle aspiration biopsy (FNAB) cytomorphologic features of two cases of salivary gland mycosis. Both patients had acquired immunodeficiency syndrome (AIDS) and presented with parotid gland masses. The first patient had Histoplasmosis with secondary infection by Candida. Cytopathologically, the FNAB smears showed classic features of a deep-seated mycosis characterized by necrosis and scattered fungal forms. The second patient had a colonizing sialadenitis caused by either Asperigillus or Fusarium. Cytopathologically, the findings were similar to those seen in aspergillomas of the lung or paranasal sinuses with numerous hyphal forms and an absence of an inflammatory response. Because mycotic disease can induce a wide spectrum of pathogenic change, other benign or malignant, solid or cystic lesions enter into the differential diagnosis.

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“…It generally occurs in patients with severe neutropenia (7). The other main predisposing conditions are uncontrolled diabetes mellitus, acidosis, renal failure, deferoxamine treatment, severe burns, and immunosuppression following solid organ transplantation (8,9).…”

Section: Discussionmentioning

confidence: 99%

A Case of Pulmonary Mucormycosis Presenting with Endobronchial Involvement

Tanrıverdi¹,

Atalay²,

Kart³

et al. 2015

Eurasian J Pulmonol

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Mucormycosis is an opportunistic fungal infection that is rare but has a fatal course, occurs especially in patients with immunodeficiency, and is caused by fungi in the Zygomycetes class. Since the infection is generally caused by inhalation of spores, mostly the paranasal sinuses and lungs are affected. Diabetes mellitus and hematologic malignancies are the most common underlying diseases. It usually initiates like bacterial pneumonia, and its clinical and radiologic findings are nonspecific. Thus, a high index of suspicion is necessary. Combined medical and surgical treatment methods are recommended. We aimed to present a case of pulmonary mucormycosis with a course of endobronchial involvement.

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Fungal Infections

Cited by 25 publications

References 310 publications

Pathophysiology of unilateral pulmonary aspergillosis in an experimental rat model

Pathophysiology of unilateral pulmonary aspergillosis in an experimental rat model

Fine‐needle aspiration biopsy of salivary gland mycoses

A Case of Pulmonary Mucormycosis Presenting with Endobronchial Involvement

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