Fungal Endophytes: A Blooming Reservoir for Future Products

Abstract

Endophytic fungi isolated from plants serve as a significant and novel source of biotherapeutic compounds with their potential application in several fields. As plant sources are widely investigated as new chemical existence in therapeutic purposes, so endophytes residing inside it also contribute to being a significant source for drug discovery. Currently, human faces a lot of challenges for surviving due to the emergence of unknown diseases, infections and also resistance to drugs in the ecosystem. So, demand has been increased in the medicinal field for the requirement of bioactive compounds productions. To overcome these, endophytes can be considered as an alternative potential source. Different types of endophytes exist, in which fungi are considered to be a rarely unexplored microorganism as it is a reservoir of largely unexploited bioactive metabolites. This review mainly focused on the ecofriendly relationship with their host and also its biotherapeutic potential in treating several diseases.

Effect of Rosemary Endophytic Fungal Extract on Microhardness of Enamel and Its Inhibitory Effect on Glucosyltransferase Enzyme of Streptococcus mutans- An In Vitro Study

“…Furthermore, endophytic fungal extract of rosemary obtained from the species Chaetomium globosum managed to inhibit glucosyltransferase enzyme, production of glucan and subsequent biofilm production of Streptococcus mutans which was in agreement with [61,68,69] who studied the ability of endophytic fungal extracts of several plants and reported the ability of these extracts to inhibit the targeted enzyme. This can be attributed to the ability of endophytic fungi to produce the same phytochemicals and active compounds produced by their host plants as explained by [70][71][72][73][74][75][76] . They explained that production of bioactive components from endophytic fungi of medicinal plants is considered an easier, costeffective alternative method for mass production of bioactive compounds that avoids over harvesting and endangering of medicinal plants.…”