Fungal chitosan from Agaricus bisporus (Lange) Sing. Chaidam increased the stability and antioxidant activity of liposomes modified with biosurfactants and loading betulinic acid

Wu, Jianan; Niu, Yongwu; Jiao, Yingchun; Chen, Qihe

doi:10.1016/j.ijbiomac.2018.11.062

Cited by 38 publications

(22 citation statements)

References 37 publications

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“…Interestingly, MELs specialize in self-assembly properties and form vesicle structure with thermodynamic stability, and have great potential to participate in liposome fabrication and stabilize the bilayer structure [112]. For example, Wu et al demonstrated the chitosan-coated liposome with loading betulinic acid was modified by MEL-A, and the results implied MEL-A boosted the antioxidant effect of betulinic acid [113]. Fan et al successfully prepared stable vesicles consisting of L-α-phosphatidylcholine (PC) and MEL-A by a thin lipid film hydration technique and evaluated their structural characterization, stability, and encapsulation efficiency [114].…”

Section: Liposomesmentioning

confidence: 99%

Contributions of Glycolipid Biosurfactants and Glycolipid-Modified Materials to Antimicrobial Strategy: A Review

et al. 2021

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Glycolipid biosurfactants are natural amphiphiles and have gained particular interest recently in their biodegradability, diversity, and bioactivity. Microbial infection has caused severe morbidity and mortality and threatened public health security worldwide. Glycolipids have played an important role in combating many diseases as therapeutic agents depending on the self-assembly property, the anticancer and anti-inflammatory properties, and the antimicrobial properties, including antibacterial, antifungal, and antiviral effects. Besides, their role has been highlighted as scavengers in impeding the biofilm formation and rupturing mature biofilm, indicating their utility as suitable anti-adhesive coating agents for medical insertional materials leading to a reduction in vast hospital infections. Notably, glycolipids have been widely applied to the synthesis of novel antimicrobial materials due to their excellent amphipathicity, such as nanoparticles and liposomes. Accordingly, this review will provide various antimicrobial applications of glycolipids as functional ingredients in medical therapy.

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Section: Liposomesmentioning

confidence: 99%

Contributions of Glycolipid Biosurfactants and Glycolipid-Modified Materials to Antimicrobial Strategy: A Review

et al. 2021

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“…The peak shape was slightly asymmetrical with only a slight skewing towards higher temperatures, which was consistent with previous research 42,43 . Compared with SPC liposomes, no other peaks appeared in PBE liposomes, indicating that PBE did not disturb the liposome membrane structure by DSC measurement 44 . These results were consistent with the results of Raman spectroscopy.…”

Section: Dsc Analysismentioning

confidence: 89%

Effects of Phytosterol Butyrate Ester on the Characteristics of Soybean Phosphatidylcholine Liposomes

Hou

Sun

et al. 2021

J. Oleo Sci.

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IntroductionThere has been an increase in research investigating the role of liposomes in drug delivery and sustained release of bioactive compounds in the pharmaceutical, cosmetics, and food industries 1, 2 . Liposomes have been widely used to incorporate essential oils 3 , vitamins 4 , minerals 5 , enzymes 6 , antioxidants 7 , antibacterial agents 8 , etc. Liposomes are constituted amphiphilic lipid/phospholipid molecules and are well known as spherical vesicles with an aqueous core. These vesicles have several advantages, such as high bioavailability, biodegradability, and biocompatibility 9, 10 . The characteristics of liposomes depend on their composition, preparation method, and environmental conditions. Traditionally, cholesterol was added to the lipid membrane to improve the characteristics of the lipid

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“…According to Wu et al, fungal chitosan with a molecular mass between 1 to 120 kDa is considered to be of a low molecular weight [ 30 ]. However, according to reports by Bezrodnykh et al (2018) [ 31 ], chitosan with a molecular mass below 16 kDa is considered to be oligochitosan.…”

Section: Discussionmentioning

confidence: 99%

“…Therefore, some authors recommend that the chitosan DD ideal for medical applications is in the range of 70–85% [ 36 ]. Thus, the DD of C. elegans oligochitosan was determined using C-N stretching of amide III and N-H bending of the primary amine, which was conducted to identify deacetylation groups in chitosan polysaccharide [ 29 , 30 , 31 , 32 , 33 , 34 , 35 , 36 , 37 , 38 ].…”

Section: Discussionmentioning

confidence: 99%

Oligochitosan Synthesized by Cunninghamella elegans, a Fungus from Caatinga (The Brazilian Savanna) Is a Better Antioxidant than Animal Chitosan

et al. 2021

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Animal chitosan (Chit-A) is gaining more acceptance in daily activities. It is used in a range of products from food supplements for weight loss to even raw materials for producing nanoparticles and hydrogel drug carriers; however, it has low antioxidant activity. Fungal oligochitosan (OChit-F) was identified as a potential substitute for Chit-A. Cunninghamella elegans is a fungus found in the Brazilian savanna (Caatinga) that produces OligoChit-F, which is a relatively poorly studied compound. In this study, 4 kDa OChit-F with a 76% deacetylation degree was extracted from C. elegans. OChit-F showed antioxidant activity similar to that of Chit-A in only one in vitro test (copper chelation) but exhibited higher activity than that of Chit-A in three other tests (reducing power, hydroxyl radical scavenging, and iron chelation). These results indicate that OChit-F is a better antioxidant than Chit-A. In addition, Chit-A significantly increased the formation of calcium oxalate crystals in vitro, particularly those of the monohydrate (COM) type; however, OChit-F had no effect on this process in vitro. In summary, OChit-F had higher antioxidant activity than Chit-A and did not induce the formation of CaOx crystals. Thus, OChit-F can be used as a Chit-A substitute in applications affected by oxidative stress.

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Fungal chitosan from Agaricus bisporus (Lange) Sing. Chaidam increased the stability and antioxidant activity of liposomes modified with biosurfactants and loading betulinic acid

Cited by 38 publications

References 37 publications

Contributions of Glycolipid Biosurfactants and Glycolipid-Modified Materials to Antimicrobial Strategy: A Review

Contributions of Glycolipid Biosurfactants and Glycolipid-Modified Materials to Antimicrobial Strategy: A Review

Effects of Phytosterol Butyrate Ester on the Characteristics of Soybean Phosphatidylcholine Liposomes

Oligochitosan Synthesized by Cunninghamella elegans, a Fungus from Caatinga (The Brazilian Savanna) Is a Better Antioxidant than Animal Chitosan

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