Fundus photography of width and intensity profiles of the blood column and the light reflex in retinal vessels

Brinchmann‐Hansen, Olaf; Heier, Halvor; Myhre, Kjell

doi:10.1111/j.1755-3768.1986.tb00699.x

Cited by 17 publications

(4 citation statements)

References 9 publications

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“…Retinal arteriolar widening has also been shown to be associated with retinopathy by several population studies. [ 21 , 22 ] A similar relationship was also investigated in the Multi-ethnic Study of Atherosclerosis (MESA), a prospective multi-ethnic population cohort who initially did not have baseline cardiovascular disease[ 23 ]. The MESA study demonstrated a significant association between wider retinal arteriolar calibre and increased risk of developing diabetes.…”

Section: Discussionmentioning

confidence: 99%

Association between Retinal Arteriolar and Venule Calibre with Prevalent Heart Failure: A Cross-Sectional Study

et al. 2015

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BackgroundThere is evidence to suggest that microvascular disease, particularly diabetic retinopathy, plays a role in the pathogenesis of HF. However, whether changes in retinal vessel calibre predicts HF is unclear. The purpose of this study was to examine the association of retinal microvascular structure with prevalent heart failure (HF).MethodsThe Australian Heart Eye Study (AHES) is a cross-sectional study that surveyed 1680 participants who presented to a tertiary referral hospital for the evaluation of potential coronary artery disease by coronary angiography. Retinal vessel calibre was graded using retinal photography and participants’ self-reported echocardiography-confirmed HF was obtained via an extensive medical questionnaire.ResultsThere were 107 participants (8.1%) with prevalent self-reported HF. Persons with wider retinal arteriolar calibre (comparing highest versus lowest tertile or reference) were more likely to have prevalent HF (OR 3.5; 95% CI, 1.7–7.2) when adjusted for age and sex. After further adjustment for body mass index, hypertension, diabetes, smoking status, triglycerides and estimated glomerular filtration rate, this association remained significant (OR 4.5; 95% CI, 2.0–9.8). After further stratification, this association remained significant among participants with diabetes (OR 10.3; 95% CI, 2.7–39.3) but not in those without diabetes (OR 2.7; 95% CI, 0.9–7.5). The strength of this association was not dependent on the length of history of diabetes, or retinopathy status. There was no significant association between retinal venular calibre and prevalence of HF.ConclusionsWider retinal arteriolar diameter was significantly and independently associated with prevalent HF in participants of a cross-sectional study. This association was significant stronger among participants with diabetes compared to without diabetes. No association was found between retinal venule calibre with prevalent HF.

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Section: Discussionmentioning

confidence: 99%

Association between Retinal Arteriolar and Venule Calibre with Prevalent Heart Failure: A Cross-Sectional Study

et al. 2015

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“…The hypoxic exposure may affect the focusing precision of the photography. If so, an increase in standard deviation is expected in intensity measurements, but not in width meaurements (Brinchmann-Hansen et al 1986;Heier & Brinchmann-Hansen 1989). The objectivity of the technique will, however, not bias the results in any specific direction.…”

Section: Variability Of Resultsmentioning

confidence: 96%

“…We studied the width and the intensity profile of the central light reflex. The marking technique on the films, the scanning procedure, and the computerized data analysis have previously been described in detail (Brinchmann-Hansen & Engvold 1986a;Brinchmann-Hansen et al 1986;Heier & Brinchmann-Hansen 1989). Typical scan profiles across a retinal vessel is illustrated in Fig.…”

Section: Methodsmentioning

confidence: 99%

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The effect of hypoxia on the central light reflex of retinal arteries and veins

Brinchmann‐Hansen

Myhre²

1989

Acta Ophthalmologica

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Computerized scanning microdensitometry was used on fundus photographs of 40 men (aged 18-23 years) and effects of hypoxia on intensity profiles of the 'light reflex' in 140 arteries and 138 veins were analysed. Changes from sea level to four levels of acute hypoxia of simulated altitude were studied: 8000 feet (ft) (2438 meters) (m), 10,000 ft (3048 m), 12,500 ft (3810 m), and 15,000 ft (4572 m) using a low-pressure chamber. The intensity of the reflex increased at 12,500 ft and 15,000 ft by 24% (P less than 0.05) and 39% (P less than 0.01) in arteries and 50% and 33% in veins (P less than 0.05), respectively. As an overall response from sea level to all four altitudes, the width of the reflex was reduced. The reduction in width was negatively correlated to the diameter of the arteries (P less than 0.0001) and veins (P less than 0.001) at sea level, and the variability of changes was larger in veins (P less than 0.01). Funduscopic light reflected from intravascular blood columns of retinal vessels is thus influenced by hypoxic stress, and 12,500 ft of simulated altitude represents a threshold value of circulatory interest.

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The Relation of Retinal Vessel Caliber to the Incidence and Progressionof Diabetic Retinopathy

Klein

Klein²,

Moss³

et al. 2004

Arch Ophthalmol

215

147

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Fundus photography of width and intensity profiles of the blood column and the light reflex in retinal vessels

Cited by 17 publications

References 9 publications

Association between Retinal Arteriolar and Venule Calibre with Prevalent Heart Failure: A Cross-Sectional Study

Association between Retinal Arteriolar and Venule Calibre with Prevalent Heart Failure: A Cross-Sectional Study

The effect of hypoxia on the central light reflex of retinal arteries and veins

The Relation of Retinal Vessel Caliber to the Incidence and Progressionof Diabetic Retinopathy

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