Fundamentals of Quantitative Dynamic Contrast-Enhanced MR Imaging

Paldino, Michael J.; Barboriak, Daniel P.

doi:10.1016/j.mric.2009.01.007

Cited by 118 publications

(96 citation statements)

References 68 publications

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“…Limitations of our study included its retrospective design and relatively small sample size. The DCE MR imaging protocol that we used is similar to routine clinical protocols in many institutions in terms of spatial and temporal resolution (1,22,(39)(40)(41)(42); spatial resolution was relatively high (approximately 1 mm isotropic), but cohort and with a fast imaging method is required to determine if BP enhancement can be used to determine a time in the menstrual cycle when the diagnostic accuracy of DCE MR imaging for breast cancer is optimal. temporal resolution was quite low (40 seconds in this study) to cover the whole breast.…”

Section: Discussionmentioning

confidence: 99%

Evaluation of the Kinetic Properties of Background Parenchymal Enhancement throughout the Phases of the Menstrual Cycle

Amarosa¹,

McKellop²,

Leite³

et al. 2013

Radiology

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Purpose:To develop and apply a semiautomatic method of segmenting fibroglandular tissue to quantify magnetic resonance (MR) imaging contrast material-enhancement kinetics of breast background parenchyma (BP) and lesions throughout the phases of the menstrual cycle in women with benign and malignant lesions. Materials and Methods:The institutional review board approved this retrospective HIPAA-compliant study, and informed consent was waived. From December 2008 to August 2011, 58 premenopausal women who had undergone contrast materialenhanced MR imaging and MR imaging-guided biopsy were identified. The longest time from the start of the last known period was 34 days. One lesion per patient (37 benign and 21 malignant) was analyzed. The patient groups were stratified according to the week of the menstrual cycle when MR imaging was performed. A method based on principal component analysis (PCA) was applied for quantitative analysis of signal enhancement in the BP and lesions by using the percentage of slope and percentage of enhancement. Linear regression and the Mann-Whitney U test were used to assess the association between the kinetic parameters and the week of the menstrual cycle. Results:In the women with benign lesions, percentages of slope and enhancement for both BP and lesions during week 2 were significantly (P , .05) lower than those in week 4. Percentage of enhancement in the lesion in week 2 was lower than that in week 3 (P , .05). The MR images of women with malignant lesions showed no significant difference between the weeks for any of the parameters. There was a strong positive correlation between lesion and BP percentage of slope (r = 0.72) and between lesion and BP percentage of enhancement (r = 0.67) in the benign group. There was also a significant (P = .03) difference in lesion percentage of slope between the benign and malignant groups at week 2. Conclusion:The PCA-based method can quantify contrast enhancement kinetics of BP semiautomatically, and kinetics of BP and lesions vary according to the week of the menstrual cycle in benign but not in malignant lesions.q RSNA, 2013

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Section: Discussionmentioning

confidence: 99%

Evaluation of the Kinetic Properties of Background Parenchymal Enhancement throughout the Phases of the Menstrual Cycle

Amarosa¹,

McKellop²,

Leite³

et al. 2013

Radiology

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“…6 Dynamic contrast enhanced (DCE) perfusion alternatively uses a T1-relaxivity approach, generating quantitative parameters such as the volumetric transfer constant (K-trans), fractional plasma volume (Vp), and fractional volume of the extracellular extravascular space (Ve), as well as semiquantitative parameters based on the area under the curve (AUC) of signal intensity-time. 8,9 Both perfusion-weighted imaging (PWI) approaches hold promise in separating radiation and chemotherapy effects from tumor (see Supplementary Fig. E1 for an example).…”

Section: Neuro-oncologymentioning

confidence: 99%

“…Non-model-based analyses with DCE avoid this problem but have an unclear physiological basis. 6,8 The result has been the diversity of methods of imaging, processing, and analysis that are evident in the literature. Despite these limitations, our study shows that within individual studies, PWI parameters separate viable tumor from treatment changes with relatively good sensitivity and specificity using study-specific thresholds.…”

Section: Neurooncologymentioning

confidence: 99%

MR perfusion-weighted imaging in the evaluation of high-grade gliomas after treatment: a systematic review and meta-analysis

et al. 2016

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Background. Distinction between tumor and treatment related changes is crucial for clinical management of patients with high-grade gliomas. Our purpose was to evaluate whether dynamic susceptibility contrast-enhanced (DSC) and dynamic contrast enhanced (DCE) perfusion-weighted imaging (PWI) metrics can effectively differentiate between recurrent tumor and posttreatment changes within the enhancing signal abnormality on conventional MRI. Methods. A comprehensive literature search was performed for studies evaluating PWI-based differentiation of recurrent tumor and posttreatment changes in patients with high-grade gliomas (World Health Organization grades III and IV). Only studies published in the "temozolomide era" beginning in 2005 were included. Summary estimates of diagnostic accuracy were obtained by using a random-effects model. Results. Of 1581 abstracts screened, 28 articles were included. The pooled sensitivities and specificities of each study's best performing parameter were 90% and 88% (95% CI: 0.85-0.94; 0.83-0.92) and 89% and 85% (95% CI: 0.78-0.96; 0.77-0.91) for DSC and DCE, respectively. The pooled sensitivities and specificities for detecting tumor recurrence using the 2 most commonly evaluated parameters, mean relative cerebral blood volume (rCBV) (threshold range, 0.9-2.15) and maximum rCBV (threshold range, 1.49-3.1), were 88% and 88% (95% CI: 0.81-0.94; 0.78-0.95) and , respectively. Conclusions. PWI-derived thresholds separating viable tumor from treatment changes demonstrate relatively good accuracy in individual studies. However, because of significant variability in optimal reported thresholds and other limitations in the existing body of literature, further investigation and standardization is needed before implementing any particular quantitative PWI strategy across institutions.

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“…The process of gadolinium leakage from intravascular-to-extravascular compartments depends on multiple factors such as blood flow to tissue, microvascular attenuation, vascular permeability, and fractional volume of extracellular extravascular space (EES). 7 These biologic features can be assessed by DCE-MR imaging.…”

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confidence: 99%

Dynamic Contrast-Enhanced MR Imaging in Head and Neck Cancer: Techniques and Clinical Applications

Gaddikeri

Tailor

et al. 2015

AJNR Am J Neuroradiol

100

117

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SUMMARY:In the past decade, dynamic contrast-enhanced MR imaging has had an increasing role in assessing the microvascular characteristics of various tumors, including head and neck cancer. Dynamic contrast-enhanced MR imaging allows noninvasive assessment of permeability and blood flow, both important features of tumor hypoxia, which is a marker for treatment resistance for head and neck cancer. Dynamic contrast-enhanced MR imaging has the potential to identify early locoregional recurrence, differentiate metastatic lymph nodes from normal nodes, and predict tumor response to treatment and treatment monitoring in patients with head and neck cancer. Quantitative analysis is in its early stage and standardization and refinement of technique are essential. In this article, we review the techniques of dynamic contrast-enhanced MR imaging data acquisition, analytic methods, current limitations, and clinical applications in head and neck cancer. ABBREVIATIONS:AIF ϭ arterial input function; DCE-MR imaging ϭ dynamic contrast-enhanced MR imaging; EES ϭ extracellular extravascular space; GCA ϭ

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Fundamentals of Quantitative Dynamic Contrast-Enhanced MR Imaging

Cited by 118 publications

References 68 publications

Evaluation of the Kinetic Properties of Background Parenchymal Enhancement throughout the Phases of the Menstrual Cycle

Evaluation of the Kinetic Properties of Background Parenchymal Enhancement throughout the Phases of the Menstrual Cycle

MR perfusion-weighted imaging in the evaluation of high-grade gliomas after treatment: a systematic review and meta-analysis

Dynamic Contrast-Enhanced MR Imaging in Head and Neck Cancer: Techniques and Clinical Applications

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