Evaluation of the Kinetic Properties of Background Parenchymal Enhancement throughout the Phases of the Menstrual Cycle

Amarosa, Alana; McKellop, Jason; Leite, Ana Paula Klautau; Moccaldi, Melanie; Clendenen, Tess V.; Babb, James S.; Zeleniuch‐Jacquotte, Anne; Moy, Linda; Kim, Sungheon

doi:10.1148/radiol.13121101

Cited by 42 publications

(38 citation statements)

References 48 publications

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“…younger women) (15–17). This is consistent with previous results with high temporal resolution imaging from Jansen et al (9), who sampled a limited number of slices with 7 second resolution and demonstrated that this approach detects significant differences between the early enhancement of DCIS and normal parenchyma, thus improving conspicuity of small diffuse cancers.…”

Section: Discussionmentioning

confidence: 99%

Ultrafast Bilateral DCE-MRI of the Breast with Conventional Fourier Sampling

et al. 2016

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Rationale and objectives To evaluate the feasibility and advantages of a combined high temporal/high spatial resolution protocol for DCE-MRI of the breast. Materials and methods Twenty-three patients with enhancing lesions were imaged at 3T. The acquisition protocol consisted of a series of bilateral, fat-suppressed ‘ultrafast’ acquisitions, with 6.9-9.9 s temporal resolution, for the first minute following contrast injection; followed by four high spatial resolution acquisitions with 60–79.5 s temporal resolution. All images were acquired with standard uniform Fourier sampling. A filtering method was developed to reduce noise and detect significant enhancement in the high temporal resolution images. Time-of-arrival (TOA) was defined as the time at which each voxel first satisfied all the filter conditions, relative to the time of initial arterial enhancement. Results Ultrafast images improved visualization of the vasculature feeding and draining lesions. A small percentage of the entire field-of-view (<6%) enhanced significantly in the 30 s following contrast injection. Lesion conspicuity was highest in early ultrafast images, especially in cases with marked parenchymal enhancement. While the sample size was relatively small, the average TOA for malignant lesions was significantly shorter than the TOA for benign lesions. Significant differences were also measured in other parameters descriptive of early contrast media uptake kinetics (p<0.05). Conclusions Ultrafast imaging in the first minute of breast DCE-MRI has the potential to add valuable information regarding early contrast dynamics. Ultrafast imaging could allow radiologists to confidently identify lesions in the presence of marked background parenchymal enhancement.

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Section: Discussionmentioning

confidence: 99%

Ultrafast Bilateral DCE-MRI of the Breast with Conventional Fourier Sampling

et al. 2016

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“…57 Wu et al 60 used a validated fully automated method that allowed segmentation and quantitative measure of fibroglandular tissues and BPE. 60 Qualitative and quantitative background parenchymal enhancement assessment Among the 11 studies that assessed BPE in both qualitative and quantitative methods, 7,20,22,24,29,30,32,34,35,46,47 27% (3/11) studies were published in 2015 (January-October 2015) and 73% (8/11) studies were published during 2010-2014. Most of the studies were performed in the USA (3/11 studies) and the Korea (3/11 studies).…”

Section: Quantitative Background Parenchymal Enhancement Assessmentmentioning

confidence: 99%

“…In a total of 14 studies, the authors stated the menstrual period. 7,20,22,24,25,27,30,31,39,45,46,55,56,60 In 8 of these 14 studies, breast MRI were performed ideally in the second week of the menstrual cycle. 7,22,24,25,27,45,56,60 In three studies, 37,47,58 the patients were post-menopausal females.…”

Section: Quantitative Background Parenchymal Enhancement Assessmentmentioning

confidence: 99%

Evaluation of background parenchymal enhancement on breast MRI: a systematic review

Bignotti¹,

Signori²,

Valdora³

et al. 2017

The British Journal of Radiology

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Objective: To perform a systematic review of the methods used for background parenchymal enhancement (BPE) evaluation on breast MRI. Methods: Studies dealing with BPE assessment on breast MRI were retrieved from major medical libraries independently by four reviewers up to 6 October 2015. The keywords used for database searching are "background parenchymal enhancement", "parenchymal enhancement", "MRI" and "breast". The studies were included if qualitative and/or quantitative methods for BPE assessment were described. Results: Of the 420 studies identified, a total of 52 articles were included in the systematic review. 28 studies performed only a qualitative assessment of BPE, 13 studies performed only a quantitative assessment and 11 studies performed both qualitative and quantitative assessments. A wide heterogeneity was found in the MRI sequences and in the quantitative methods used for BPE assessment. Conclusion: A wide variability exists in the quantitative evaluation of BPE on breast MRI. More studies focused on a reliable and comparable method for quantitative BPE assessment are needed. Advances in knowledge: More studies focused on a quantitative BPE assessment are needed.

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“…Several studies have suggested that BPE represents physiological hormonal enhancement, reflecting hormone-related changes in breast composition and vascularity. Fluctuations in BPE have been demonstrated throughout the menstrual cycle, with the highest levels of enhancement in the second half of the menstrual cycle during the luteal phase when breast cell proliferation is at its highest [20]. BPE has also been demonstrated to reflect variations in estrogen-mediated vascular permeability, with increased BPE seen in women taking estrogen replacement therapy, and decreased BPE with anti-estrogen medications and in postmenopausal patients [23–30].…”

Section: Disscussionmentioning

confidence: 99%

The relationship of breast density in mammography and magnetic resonance imaging in high-risk women and women with breast cancer

et al. 2015

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Structured Abstract Purpose To evaluate the relationship between mammographic breast density (MBD), background parenchymal enhancement (BPE), and fibroglandular tissue (FGT) in women with breast cancer (BC) and at high risk for developing BC. Methods Our institutional database was queried for patients who underwent mammography and MRI. Results 403 (85%) had BC and 72 (15%) were at high risk. MBD (p=0.0005), BPE (p<0.0001), and FGT (p=0.02) were all higher in high risk women compared to the BC group. Conclusions Higher levels of MBD, BPE and FGT are seen in women at higher risk for developing BC when compared to women with BC.

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Evaluation of the Kinetic Properties of Background Parenchymal Enhancement throughout the Phases of the Menstrual Cycle

Cited by 42 publications

References 48 publications

Ultrafast Bilateral DCE-MRI of the Breast with Conventional Fourier Sampling

Ultrafast Bilateral DCE-MRI of the Breast with Conventional Fourier Sampling

Evaluation of background parenchymal enhancement on breast MRI: a systematic review

The relationship of breast density in mammography and magnetic resonance imaging in high-risk women and women with breast cancer

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