Fundamentals of 3D Printing and Its Applications in Biomedical Engineering

Sürmen, Hasan Kemal; Örteş, Faruk; Arslan, Yunus Ziya

doi:10.1007/978-981-15-5424-7_2

Cited by 4 publications

(1 citation statement)

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“…3D-bioprinted models of cancer have contributed to our understanding of the disease significantly and have served as excellent models to test new drugs and therapies in vitro [49]. Furthermore, 3D printing not only saves expenses and time during manufacturing but also enables the usage of clinical research products by constructing intricate models and designing free-form geometric biomedical devices [41,42,65,66].…”

Section: D Bioprintingmentioning

confidence: 99%

3D bioprinted glioma models

et al. 2022

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Glioma is one of the most malignant types of cancer and most gliomas remain incurable. One of the hallmarks of glioma is its invasiveness. Furthermore, glioma cells tend to readily detach from the primary tumor and travel through the brain tissue, making complete tumor resection impossible in many cases. To expand the knowledge regarding the invasive behavior of glioma, evaluate drug resistance, and recapitulate the tumor microenvironment, various modeling strategies were proposed in the last decade, including 3D biomimetic scaffold-free cultures, organ-on-chip microfluidics chips, and 3D bioprinting platforms, which allow for the investigation on patient-specific treatments. The emerging method of 3D bioprinting technology has introduced a time- and cost-efficient approach to create in vitro models that possess the structural and functional characteristics of human organs and tissues by spatially positioning cells and bioink. Here, we review emerging 3D bioprinted models developed for recapitulating the brain environment and glioma tumors, with the purpose of probing glioma cell invasion and gliomagenesis and discuss the potential use of 4D printing and machine learning applications in glioma modelling.

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