Fundamental principles affecting the outcomes of therapy for osseous lesions

Kornman, Kenneth S.; Robertson, Paul B.

doi:10.1034/j.1600-0757.2000.2220103.x

Cited by 86 publications

(102 citation statements)

References 158 publications

(188 reference statements)

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“…We selected one or two wall periodontal infrabony defects for this study because various studies have proposed that the three wall infrabony defects inherently heal more favorably. [222324] A biological explanation of this healing pattern has been related to the fact that the number of bony walls of the defect will influence, among other factors, the source of osteoprogenitor cells. An alternative explanation, should be considered that one wall component, when present, is more exchangeable to surroundings, more susceptible to oral environmental and thus filling materials would have more chance to get contamination, factors leading to an incomplete bone fill.…”

Section: Discussionmentioning

confidence: 99%

“…Difference in the outcomes of the various studies might be due to the variation in several associated factors that can alter the extent of clinical attachment gain and bone regrowth following a grafting procedure, such as patients selection, defects characteristics, data collection, biochemical characteristics of grafted materials, surgical variation and patient attitude toward the treatment. [2324]…”

Section: Discussionmentioning

confidence: 99%

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Comparative evaluation of decalcified freeze dried bone allograft with and without local doxycycline in non-contained human periodontal infrabony defects

Agarwal¹,

Bhattacharya²,

Gadicherla³

et al. 2013

J Indian Soc Periodontol

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Background:Doxycycline has been advocated as useful adjuncts in periodontal therapy not only due to their antimicrobial actions, but also to their recently recognized anti-collagenolytic, anti-inflammatory, osteoclast inhibitory and fibroblast stimulating property. The purpose of the present cohort study was to evaluate the regenerative outcomes of bone graft with or without local doxycycline in non-contained infrabony periodontal defects.Materials and Methods:16 one or two wall infrabony defects, in 11 patients suffering from moderate to severe chronic periodontitis, aged 35-60 years, were randomly divided for bone graft, alone (control) and with doxycycline (test) for the study. At baseline, after 3 months and after 6 months of post-operative period, pocket probing depth (PPD), clinical attachment level (CAL), radiological bone fill (RBF) and alveolar height reduction were recorded. Analysis of variance and Newman-Keuls post-hoc test were used or statistical analysis. A two-tailed probability (P) value P < 0.05 was considered to be statistically significant.Results:For the control group PPD reduction 2.00 ± 0.18 mm, CAL gain 1.38 ± 0.17 mm, RBF 0.63 ± 0.27 mm (18.0%) was observed while in the test group PPD reduction 2.00 ± 0.38 mm, CAL gain 1.25 ± 0.31 mm, RBF 0.75 ± 0.31 mm (20.7%) was evaluated. While alveolar height reduction for the control group and test group was 13% and 12.5% respectively.Conclusion:The study confirmed no added benefits of local doxycycline, as compared with bone graft alone, for regeneration of non-contained human periodontal infrabony defects.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Comparative evaluation of decalcified freeze dried bone allograft with and without local doxycycline in non-contained human periodontal infrabony defects

Agarwal¹,

Bhattacharya²,

Gadicherla³

et al. 2013

J Indian Soc Periodontol

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“…35 Since, there is a resective nature in these, the tissues get traumatized and inflamed immediately after the procedure. 36 This is followed by the period of healing in which tissue remodeling takes place with the formation of metalloproteinases (elastase, collagenase, gelatinase). These tissues are responsible for remodeling of the bone in the crestal area.…”

Section: Discussionmentioning

confidence: 99%

Comparison of the Effects of Different Laser Wavelengths on Implants Surfaces

Pradhan¹,

Doshi²,

Khandge³

2013

International Journal of Laser Dentistry

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“…However, a common problem of GTR therapy is the high variability and low predictability of healing outcomes, even as complete and predictable reconstruction of periodontal tissues is difficult to obtain with any therapeutic plan [6,7]. Specifically, the degree of healing depends on both the local characteristics of the intrabony defects and the regenerative potential of the residual periodontal tissues [4,8,9].…”

mentioning

confidence: 99%

The Effect of Concentrated Growth Factors in the Treatment of Periodontal Intrabony Defects

et al. 2016

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Aim:To investigate the effect of concentrated growth factors (CGFs) in human intrabony defect treatment.Methods:Thirty-one intrabony defects were randomly treated with CGFs + bovine porous bone mineral (BPBM) or BPBM alone. Probing depth, clinical attachment level and hard tissue fill were evaluated at baseline and 1 year post surgery.Results:No differences in any of the investigated parameters were observed at baseline. At 1 year post therapy, both groups showed significant improvement in clinical parameters (p < 0.001). CGFs + BPBM was more effective than BPBM alone at decreasing probing depth (4.2 ± 1.3 mm vs 3.0 ± 1.6 mm) and clinical attachment level gain (3.7 ± 1.3 mm vs 2.4 ± 1.1 mm; p ≤ 0.05). A favorable increase of hard tissue fill was noted in CGFs + BPBM group compared with BPBM group (p > 0.05). The contents of growth factors in CGFs were statistically higher than those in platelet poor plasma (p < 0.001).Conclusion:Addition of CGFs significantly improved clinical effectiveness of BPBM for intrabony defect treatment.

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Fundamental principles affecting the outcomes of therapy for osseous lesions

Cited by 86 publications

References 158 publications

Comparative evaluation of decalcified freeze dried bone allograft with and without local doxycycline in non-contained human periodontal infrabony defects

Comparative evaluation of decalcified freeze dried bone allograft with and without local doxycycline in non-contained human periodontal infrabony defects

Comparison of the Effects of Different Laser Wavelengths on Implants Surfaces

The Effect of Concentrated Growth Factors in the Treatment of Periodontal Intrabony Defects

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