Functions of three ubiquitin-conjugating enzyme 2 genes in hepatocellular carcinoma diagnosis and prognosis

Zhang, Chunye; Yang, Ming

doi:10.4254/wjh.v14.i5.957

Cited by 2 publications

(5 citation statements)

References 46 publications

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“…UBE2C is highly expressed in patients with TP53-mutated HCC, as are UBE2S and UBE2T. The results of this analysis of clinical patient data were confirmed by other experiments (91). Expression of UBE2S is associated with survival, metastasis and recurrence in patients with HCC and analysis of TCGA data indicated that the OS and DFS time were shorter in patients with high UBE2S expression.…”

Section: Class ⅲ E2s In Hcc Ube2s Has An Essential Role In Mitosissupporting

confidence: 74%

“…Both UBE2S and UBE2T belong to the third class of E2s, both of which have a larger role in HCC. By bioinformatics analysis, Zhang and Yang (91) found that UBE2S, UBE2T and UBE2C are associated with HCC progression. UBE2C is highly expressed in patients with TP53-mutated HCC, as are UBE2S and UBE2T.…”

Section: Class ⅲ E2s In Hcc Ube2s Has An Essential Role In Mitosismentioning

confidence: 99%

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Ubiquitin‑conjugating enzymes as potential biomarkers and therapeutic targets for digestive system cancers (Review)

Lei

et al. 2023

Oncol Rep

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Digestive system cancers are the leading cause of cancer-related death worldwide due to their high morbidity and mortality rates. The current treatment methods include surgical treatment, chemotherapy, radiotherapy and endoscopic treatment, and the precisely targeted therapy of digestive system cancers requires to be further studied. The ubiquitin-proteasome system is the main pathway for protein degradation in cells and the ubiquitin-conjugating enzymes (E2s) have a decisive role in the specific selection of target proteins for degradation. The E2s have an important physiological role in digestive system cancers, which is related to the clinical tumor stage, differentiation degree and poor prognosis. Furthermore, they are involved in the physiological processes of digestive system tumor cell proliferation, migration, invasion, stemness, drug resistance and autophagy. In the present article, the progress and achievements of the E2s in gastric cancer, hepatocellular carcinoma, pancreatic cancer, colorectal cancer, intrahepatic cholangiocarcinoma, gallbladder cancer and esophageal squamous cell carcinoma were reviewed, which may provide early screening indicators and reliable therapeutic targets for digestive system cancers.

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Section: Class ⅲ E2s In Hcc Ube2s Has An Essential Role In Mitosissupporting

confidence: 74%

Section: Class ⅲ E2s In Hcc Ube2s Has An Essential Role In Mitosismentioning

confidence: 99%

Ubiquitin‑conjugating enzymes as potential biomarkers and therapeutic targets for digestive system cancers (Review)

Lei

et al. 2023

Oncol Rep

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“…The expression level of miR-212-5p was observed to be markedly lower in HCC than in adjacent tissues, and was negatively correlated with the expression of UBE2T. miR-212-5p inhibited the malignant phenotype in a UBE2T-dependent manner (30,60).…”

Section: Expression Of Ube2t In Cancermentioning

confidence: 95%

“…Increasing evidence has verified that E2s show dysregulation in various cancer types, as they are linked to tumor-promoting processes and self-renewal abilities such as dysregulation in DNA repair, cell cycle, apoptosis and oncogenic signalling (10,(17)(18)(19)(20)(21)(22). The dysfunctional status of E2 members is considered a potential biomarker for diagnosis, prognosis and therapy in patients with various cancer types (22)(23)(24)(25)(26)(27)(28)(29)(30)(31).…”

Section: Ube2tmentioning

confidence: 99%

“…Overexpression of UBE2T was negatively correlated with prognosis and overall survival (OS) time, while it was positively correlated with pathological grade and TNM stage of HCC progression, which showed higher expression at all four stages compared with that of non-cancer control samples (8,30,63). The level of UBE2T was significantly higher in stages II and III than in stage I (30). In addition, it was confirmed to have notable advantages with HCC grade, HCC satellite lesions and vascular invasion (63).…”

Section: Expression Of Ube2t In Cancermentioning

confidence: 99%

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Diverse roles of UBE2T in cancer (Review)

Yan

et al. 2023

Oncol Rep

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As a leading cause of mortalities worldwide, cancer results from accumulation of both genetic and epigenetic alterations. Disruption of epigenetic regulation in cancer, particularly aberrant ubiquitination, has drawn increasing interest in recent years. The present study aimed to review the roles of ubiquitin-conjugating enzyme E2 T (UBE2T) and its associated pathways in the pathogenesis of pan-cancer, and the development of small-molecule modulators to regulate ubiquitination for treatment strategies. The current study comprehensively investigated the expression landscape and functional significance of UBE2T, as well as its correlation with cancer cell sensitivity to chemotherapy/radiotherapy. Multiple levels of evidence suggested that aberrant UBE2T played important roles in pan-cancer. Information was collected from 16 clinical trials on ubiquitin enzymes, and it was found that these molecules had an important role in the ubiquitin-proteasome system. Further studies are necessary to explore their feasibility and effectiveness as diagnostic and prognostic biomarkers, or as up/down-stream and therapeutic targets for cancer treatment.

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Functions of three ubiquitin-conjugating enzyme 2 genes in hepatocellular carcinoma diagnosis and prognosis

Cited by 2 publications

References 46 publications

Ubiquitin‑conjugating enzymes as potential biomarkers and therapeutic targets for digestive system cancers (Review)

Ubiquitin‑conjugating enzymes as potential biomarkers and therapeutic targets for digestive system cancers (Review)

Diverse roles of UBE2T in cancer (Review)

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