Functions of Microtubule Disassembly during Neurite Pruning

Rumpf, Sebastian; Wolterhoff, Neele; Herzmann, Svende

doi:10.1016/j.tcb.2019.01.002

Cited by 22 publications

(16 citation statements)

References 54 publications

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“…Dendrite pruning is regulated in a cell-intrinsic manner by the steroid hormone ecdysone through a transcriptional cascade that leads to the expression of specific pruning factors such as the transcription factor Sox14 and the actin-severing enzyme Mical (Kirilly et al, 2009;Kuo et al, 2005;Williams and Truman, 2005). These transcriptional changes activate pathways for cytoskeleton disassembly (Herzmann et al, 2017(Herzmann et al, , 2018Kirilly et al, 2009;Rumpf et al, 2019), which is followed by caspase-and calpain-dependent fragmentation (Kanamori et al, 2013;Williams et al, 2006) and phagocytosis by surrounding epidermal cells (Han et al, 2014).…”

Section: Introductionmentioning

confidence: 99%

AMPK adapts metabolism to developmental energy requirement during dendrite pruning in Drosophila

et al. 2021

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Section: Introductionmentioning

confidence: 99%

AMPK adapts metabolism to developmental energy requirement during dendrite pruning in Drosophila

et al. 2021

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“…In C4da neuron dendrites with their nearly uniform minus-end out MT organization, MT loss and dendrite degeneration start at proximal branch-points and expand distally until the dendrite is severed in these regions [ 41 ]. Thus, Rumpf et al proposed a model that MT disassembly is the first local degenerative event during large-scale neurite pruning and MT polarity and organization might determine pruning initiation sites and efficiency [ 47 ].…”

Section: Resultsmentioning

confidence: 99%

Spatiotemporal changes in microtubule dynamics during dendritic morphogenesis

Pan

Chen

et al. 2021

Fly

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Dendritic morphogenesis requires dynamic microtubules (MTs) to form a coordinated cytoskeletal network during development. Dynamic MTs are characterized by their number, polarity and speed of polymerization. Previous studies described a correlation between anterograde MT growth and terminal branch extension in Drosophila dendritic arborization (da) neurons, suggesting a model that anterograde MT polymerization provides a driving force for dendritic branching. We recently found that the Ste20-like kinase Tao specifically regulates dendritic branching by controlling the number of dynamic MTs in a kinase activity-dependent fashion, without affecting MT polarity or speed. This finding raises the interesting question of how MT dynamics affects dendritic morphogenesis, and if Tao kinase activity is developmentally regulated to coordinate MT dynamics and dendritic morphogenesis. We explored the possible correlation between MT dynamics and dendritic morphogenesis together with the activity changes of Tao kinase in C1da and C4da neurons during larval development. Our data show that spatiotemporal changes in the number of dynamic MTs, but not polarity or polymerization speed, correlate with dendritic branching and Tao kinase activity. Our findings suggest that Tao kinase limits dendritic branching by controlling the abundance of dynamic MTs and we propose a novel model on how regulation of MT dynamics might influence dendritic morphogenesis.

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“…The neuronal microtubule cytoskeleton is typically highly immobile in axons and dendrites of mature neurons (Kahn et al, 2018;Lu et al, 2013). During neuronal development, however, growth and retraction of neurites is intimately linked to microtubule stability and dynamics (Lewis et al, 2013;Rumpf et al, 2019). Thus, it is likely that stability of the anchoring complex itself is regulated and/or that binding of the microtubules to the anchoring complex is regulated.…”

Section: Discussionmentioning

confidence: 99%

Cortical anchoring of the microtubule cytoskeleton is essential for neuron polarity and functioning

Kooistra

Das

et al. 2019

Preprint

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Neurons are among the most highly polarized cell types. They possess structurally and functionally different processes, axon and dendrites, to mediate information flow through the nervous system.Although it is well known that the microtubule cytoskeleton has a central role in establishing neuronal polarity, how its specific organization is established and maintained is little understood.Using the in vivo model system Caenorhabditis elegans, we found that the highly conserved UNC-119 protein provides a link between the membrane-associated Ankyrin (UNC-44) and the microtubuleassociated CRMP (UNC-33). Together they form a periodic membrane-associated complex that anchors axonal and dendritic microtubule bundles to the cell cortex. This anchoring is critical to maintain microtubule organization by opposing kinesin-1 powered microtubule sliding. Disturbing this molecular complex alters neuronal polarity and causes strong developmental defects of the nervous system leading to severely paralyzed animals.

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Functions of Microtubule Disassembly during Neurite Pruning

Cited by 22 publications

References 54 publications

AMPK adapts metabolism to developmental energy requirement during dendrite pruning in Drosophila

AMPK adapts metabolism to developmental energy requirement during dendrite pruning in Drosophila

Spatiotemporal changes in microtubule dynamics during dendritic morphogenesis

Cortical anchoring of the microtubule cytoskeleton is essential for neuron polarity and functioning

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