Functions of mammalian SIRT4 in cellular metabolism and research progress in human cancer (Review)

Wang, Changming; Liu, Yan; Zhu, Yuyan; Kong, Chuize

doi:10.3892/ol.2020.11872

Cited by 12 publications

(16 citation statements)

References 123 publications

(178 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Bioinformatics analysis revealed that SIRT4 might be a direct target of miR‐130b‐5p. SIRT4, which resides mitochondria and plays a significant role in cellular metabolic processes 26 . EX‐527, as a SIRT1‐selective inhibitor, relieve hepatic fibrosis by up‐regulating SIRT4 expression 14 .…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

miRNA‐130b‐5p promotes hepatic stellate cell activation and the development of liver fibrosis by suppressing SIRT4 expression

Wang

et al. 2021

J Cellular Molecular Medi

View full text Add to dashboard Cite

Liver fibrosis is a progressive disease accompanied by the deposition of extracellular matrix (ECM). Numerous reports have demonstrated that alterations in the expression of microRNAs (miRNAs) are related to liver disease. However, the effect of individual miRNAs on liver fibrosis has not been studied. Hepatic stellate cells (HSCs), being responsible for producing ECM, exert an important influence on liver fibrosis. Then, microarray analysis of non‐activated and activated HSCs induced by transforming growth factor β1 (TGF‐β1) showed that miR‐130b‐5p expression was strongly up‐regulated during HSC activation. Moreover, the progression of liver fibrosis had a close connection with the expression of miR‐130b‐5p in different liver fibrosis mouse models. Then, we identified that there were specific binding sites between miR‐130b‐5p and the 3′ UTR of Sirtuin 4 (SIRT4) via a luciferase reporter assay. Knockdown of miR‐130b‐5p increased SIRT4 expression and ameliorated liver fibrosis in mice transfected with antagomiR‐130b‐5p oligos. In general, our results suggested that miR‐130b‐5p promoted HSC activation by targeting SIRT4, which participates in the AMPK/TGF‐β/Smad2/3 signalling pathway. Hence, regulating miR‐130b‐5p maybe serve as a crucial therapeutic treatment for hepatic fibrosis.

show abstract

Section: Discussionmentioning

confidence: 99%

“…SIRT4, which resides mitochondria and plays a significant role in cellular metabolic processes. 26 EX-527, as a SIRT1-selective inhibitor, relieve hepatic fibrosis by up-regulating SIRT4 expression. 14 A previous study indicated that SIRT4 silencing in tumour-associated macrophages promotes HCC development.…”

Section: Discussionmentioning

confidence: 99%

miRNA‐130b‐5p promotes hepatic stellate cell activation and the development of liver fibrosis by suppressing SIRT4 expression

Wang

et al. 2021

J Cellular Molecular Medi

View full text Add to dashboard Cite

show abstract

“…The use of a transgenic mouse model for cancer xenotransplantation has confirmed that a lack of SIRT4 can accelerate the progression of cancer cell death in various cancers by regulating glutamine metabolism in the mitochondria or the mammalian target of rapamycin (mTOR) pathways (Csibi et al, 2013;Jeong et al, 2013). However, its role in breast cancer and OC seems to stand at the opposite end of the spectrum (Sun et al, 2019b;Wang et al, 2020). Du et al (2020) have highlighted that SIRT4 negatively regulates SIRT1 expression by suppressing glutamine metabolism in mammary tumorigenesis, which implies the presence of competition functions within the sirtuin family.…”

Section: Discussionmentioning

confidence: 99%

SIRT4 and SIRT6 Serve as Novel Prognostic Biomarkers With Competitive Functions in Serous Ovarian Cancer

Wang

Huang

et al. 2021

Front. Genet.

View full text Add to dashboard Cite

Sirtuins (SIRTs) are class III histone deacetylases (HDACs) that include seven members and are widely expressed in mammals. Accumulating evidence shows that sirtuins may have contradictory roles in various malignancies. They mainly participate in metabolic homeostasis, DNA damage repair, cell survival, and differentiation, as well as other cancer-related biological processes. To better understand their prognostic role and biological functions, we used comprehensive bioinformatic analyses to demonstrate the expression and mutation of sirtuin family member genes in ovarian cancer (OC), with a detailed focus on prognostic prediction, including the effectiveness of anti-OC drugs. Furthermore, the co-expression genes of SIRT4 and SIRT6 with contradictory survival prediction values in both overall and progression-free survival (PFS) times were further analyzed through Gene Ontology enrichment and Kyoto Encyclopedia annotation. Additionally, we performed and obtained the immunohistochemical staining patterns of these two biomarkers from the serous OC patient database and clinical patient samples to demonstrate their potential applicability in clinical pathology. According to our findings, SIRT4 and SIRT6 are novel prognostic biomarkers that may serve as contradictory competitors for OC cell survival. They are also sensitive biomarkers for the prediction of Avastin’s anticancer effect. While SIRT4 is related to the immune response during oocyte maturation, SIRT6 participates in immune-related disease pathways and mitochondrial metabolism-mediated DNA translation. These findings contribute to the novel hypothesis that SIRT4 and SIRT6 act as contradictory competitors in the regulation of OC behavior. Further studies are required to validate our hypothesis.

show abstract

“…In addition, SIRT4 has been reported to enhance E-cadherin and inhibit EMT, thereby decreasing migration and the invasion ability in gastric and colorectal cancer cells[ 70 , 71 ]. Furthermore, Hu et al [ 72 ] showed that overexpression of SIRT4 induced G1 cell cycle arrest through the inhibition of the phosphorylated extracellular signal-regulated kinases cyclin D and cyclin E. In addition, several studies have revealed that a low SIRT4 expression was significantly correlated with a poor prognosis in patients with various cancers[ 73 ].…”

Section: Sirt4mentioning

confidence: 99%

Role of sirtuins in esophageal cancer: Current status and future prospects

Otsuka¹,

Hayano²,

Matsubara³

2022

WJGO

View full text Add to dashboard Cite

Esophageal cancer (EC) is a malignant cancer that still has a poor prognosis, although its prognosis has been improving with the development of multidisciplinary treatment modalities such as surgery, chemotherapy and radiotherapy. Therefore, identifying specific molecular markers that can be served as biomarkers for the prognosis and treatment response of EC is highly desirable to aid in the personalization and improvement of the precision of medical treatment. Sirtuins are a family of nicotinamide adenine dinucleotide (NAD+)-dependent proteins consisting of seven members (SIRT1-7). These proteins have been reported to be involved in the regulation of a variety of biological functions including apoptosis, metabolism, stress response, senescence, differentiation and cell cycle progression. Given the variety of functions of sirtuins, they are speculated to be associated in some manner with cancer progression. However, while the role of sirtuins in cancer progression has been investigated over the past few years, their precise role remains difficult to characterize, as they have both cancer-promoting and cancer-suppressing properties, depending on the type of cancer. These conflicting characteristics make research into the nature of sirtuins all the more fascinating. However, the role of sirtuins in EC remains unclear due to the limited number of reports concerning sirtuins in EC. We herein review the current findings and future prospects of sirtuins in EC.

show abstract

Functions of mammalian SIRT4 in cellular metabolism and research progress in human cancer (Review)

Cited by 12 publications

References 123 publications

miRNA‐130b‐5p promotes hepatic stellate cell activation and the development of liver fibrosis by suppressing SIRT4 expression

miRNA‐130b‐5p promotes hepatic stellate cell activation and the development of liver fibrosis by suppressing SIRT4 expression

SIRT4 and SIRT6 Serve as Novel Prognostic Biomarkers With Competitive Functions in Serous Ovarian Cancer

Role of sirtuins in esophageal cancer: Current status and future prospects

Contact Info

Product

Resources

About